ID   ETS2A_XENLA             Reviewed;         472 AA.
AC   P19102;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 2.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Protein c-ets-2-A;
DE            Short=C-ets-2A;
GN   Name=ets2-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1741266; DOI=10.1093/nar/20.2.371;
RA   Burdett L.A., Qi S.M., Chen Z.-Q., Lautenberger J.A., Papas T.S.;
RT   "Characterization of the cDNA sequences of two Xenopus ets-2 proto-
RT   oncogenes.";
RL   Nucleic Acids Res. 20:371-371(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 121-472.
RC   TISSUE=Oocyte;
RX   PubMed=2201951; DOI=10.1093/nar/18.15.4603;
RA   Wolff C.M., Stiegler P., Baltzinger M., Meyer D., Ghysdael J., Stehelin D.,
RA   Befort N., Remy P.;
RT   "Isolation of two different c-ets-2 proto-oncogenes in Xenopus laevis.";
RL   Nucleic Acids Res. 18:4603-4604(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 121-472.
RX   PubMed=1751411;
RA   Wolff C.M., Stiegler P., Baltzinger M., Meyer D., Ghysdael J., Stehelin D.,
RA   Befort N., Remy P.;
RT   "Cloning, sequencing, and expression of two Xenopus laevis c-ets-2
RT   protooncogenes.";
RL   Cell Growth Differ. 2:447-456(1991).
CC   -!- FUNCTION: Probable transcription factor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR   EMBL; M81683; AAA49705.1; -; mRNA.
DR   EMBL; X51826; CAA36124.1; -; mRNA.
DR   PIR; S28824; B53236.
DR   AlphaFoldDB; P19102; -.
DR   SMR; P19102; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR045688; Ets1_N_flank.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR046328; ETS_fam.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR016311; Transform_prot_C-ets.
DR   InterPro; IPR027276; Transform_prot_C-ets-2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849; PTHR11849; 1.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF19525; Ets1_N_flank; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PIRSF; PIRSF501032; C-ets-2; 1.
DR   PIRSF; PIRSF001698; Transforming_factor_C-ets; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..472
FT                   /note="Protein c-ets-2-A"
FT                   /id="PRO_0000204080"
FT   DOMAIN          85..170
FT                   /note="PNT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00762"
FT   DNA_BIND        366..446
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
SQ   SEQUENCE   472 AA;  53895 MW;  E0E8088B5E6BF111 CRC64;
     MTEFGIRNMD QVAPVYNGHR AMLKRQLAFD NVSVPTSLYS GLFSAYEEEQ AVPTGLDSYS
     HDSSSCELPL LTPCSKAVMS QALKNTFNGF AKKRFRLGIL SNPWLWDENN VFQWLWWAAK
     EFSLQNVNFQ KFLMNGHELC SLGKERFLAL APDFVGDILW EHLEEMMKEH QEKAQEPYID
     HSNQDSINHW MNADSLNFTT DPLQCGAQVH NYPKNGMFND MCSVPTGQTL LQPKQEFQQY
     PSSCLKSRAV NYSPASQDFA RSNMNALLNS LNSGKLRDYD SGDSGTESFE STESLLQSWT
     SQSSLVDMQR VPSYDGFEED GSQALCLNKP PMSFKDYIQD RCEPAELGKP VIPASILAGF
     TGSGPIQLWQ FLLELLTDKS CQSFISWTGD GWEFKLTDPD EVARRWGKRK NKPKMNYEKL
     SRGLRYYYDK NIIHKTSGKR YVYRFVCDLH NLLGYTPDEL HAMLGVQPDT DE