ID   ETS2B_XENLA             Reviewed;         472 AA.
AC   Q91712; Q91737;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Protein c-ets-2-B;
DE            Short=C-ets-2B;
GN   Name=ets2-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RX   PubMed=2201951; DOI=10.1093/nar/18.15.4603;
RA   Wolff C.M., Stiegler P., Baltzinger M., Meyer D., Ghysdael J., Stehelin D.,
RA   Befort N., Remy P.;
RT   "Isolation of two different c-ets-2 proto-oncogenes in Xenopus laevis.";
RL   Nucleic Acids Res. 18:4603-4604(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RX   PubMed=1751411;
RA   Wolff C.M., Stiegler P., Baltzinger M., Meyer D., Ghysdael J., Stehelin D.,
RA   Befort N., Remy P.;
RT   "Cloning, sequencing, and expression of two Xenopus laevis c-ets-2
RT   protooncogenes.";
RL   Cell Growth Differ. 2:447-456(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-146.
RX   PubMed=1741266; DOI=10.1093/nar/20.2.371;
RA   Burdett L.A., Qi S.M., Chen Z.-Q., Lautenberger J.A., Papas T.S.;
RT   "Characterization of the cDNA sequences of two Xenopus ets-2 proto-
RT   oncogenes.";
RL   Nucleic Acids Res. 20:371-371(1992).
CC   -!- FUNCTION: Probable transcription factor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR   EMBL; X52635; CAA36860.1; -; mRNA.
DR   EMBL; M81684; AAA49706.1; -; mRNA.
DR   PIR; A53236; A53236.
DR   AlphaFoldDB; Q91712; -.
DR   SMR; Q91712; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR045688; Ets1_N_flank.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR046328; ETS_fam.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR016311; Transform_prot_C-ets.
DR   InterPro; IPR027276; Transform_prot_C-ets-2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849; PTHR11849; 1.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF19525; Ets1_N_flank; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PIRSF; PIRSF501032; C-ets-2; 1.
DR   PIRSF; PIRSF001698; Transforming_factor_C-ets; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..472
FT                   /note="Protein c-ets-2-B"
FT                   /id="PRO_0000204081"
FT   DOMAIN          85..170
FT                   /note="PNT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00762"
FT   DNA_BIND        366..446
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
SQ   SEQUENCE   472 AA;  53929 MW;  E98AFC77F4D446DD CRC64;
     MTEFGIRNMD QVAPVYNGHR GMLKRQLAFD NVQVPTSLYC GLFSAYEEEQ AVPTGLDSYP
     HDSSSCELPL LTPCSKAVMS QALKDTFNGF AKERCRLGIP GNPWLWDENN VLQWLLWAAK
     EFSLENVNFQ KFLMNGHELC SLGKERFLAL APDFVGDILW EHLEEMMKEY QEKAQEPYID
     HSNRDSLNQW MNADSLNFTA DPLQCGAQVH NYPKNGMYND MCSVPTGQTL LNPKQEFQQY
     PSSCLKSRAV NYPPASQDFA RSHMNVLLNS LNSGKLRDYD SGDSGTESFE STESLLHSWT
     SQSSLVDMQR VPSYDSFEED GNQTLCLNKQ PMSFKDYIQD RCEPAELGKP VIPASILAGF
     TGSGPIQLWQ FLLELLTDKS CQSFISWTGD GWEFKLADPD EVARRWGKRK NKPKMNYEKL
     SRGLRYYYDK NIIHKTSGKR YVYRFVCDLH NLLGYTPDEL HAMLGVQPDT DE