ETS2_CHICK
ID ETS2_CHICK Reviewed; 479 AA.
AC P10157;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Protein C-ets-2;
GN Name=ETS2;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Fibroblast;
RX PubMed=3293999; DOI=10.1002/j.1460-2075.1988.tb02865.x;
RA Boulukos K.E., Pognonec P., Begue A., Galibert F., Gesquiere J.C.,
RA Stehelin D., Ghysdael J.;
RT "Identification in chickens of an evolutionarily conserved cellular ets-2
RT gene (c-ets-2) encoding nuclear proteins related to the products of the c-
RT ets proto-oncogene.";
RL EMBO J. 7:697-705(1988).
CC -!- FUNCTION: Probable transcription factor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR EMBL; X07202; CAA30178.1; -; mRNA.
DR PIR; S00386; TVCHE2.
DR RefSeq; NP_990643.1; NM_205312.1.
DR AlphaFoldDB; P10157; -.
DR SMR; P10157; -.
DR STRING; 9031.ENSGALP00000025826; -.
DR PaxDb; P10157; -.
DR Ensembl; ENSGALT00000025873; ENSGALP00000025826; ENSGALG00000016059.
DR Ensembl; ENSGALT00000094617; ENSGALP00000066822; ENSGALG00000016059.
DR GeneID; 396250; -.
DR KEGG; gga:396250; -.
DR CTD; 2114; -.
DR VEuPathDB; HostDB:geneid_396250; -.
DR eggNOG; KOG3806; Eukaryota.
DR GeneTree; ENSGT00940000160202; -.
DR HOGENOM; CLU_031197_1_1_1; -.
DR InParanoid; P10157; -.
DR OMA; RSWNSQS; -.
DR OrthoDB; 526256at2759; -.
DR PhylomeDB; P10157; -.
DR Reactome; R-GGA-2559585; Oncogene Induced Senescence.
DR PRO; PR:P10157; -.
DR Proteomes; UP000000539; Chromosome 1.
DR Bgee; ENSGALG00000016059; Expressed in spermatocyte and 13 other tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0001569; P:branching involved in blood vessel morphogenesis; TAS:DFLAT.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0060982; P:coronary artery morphogenesis; TAS:DFLAT.
DR GO; GO:0001712; P:ectodermal cell fate commitment; IEA:Ensembl.
DR GO; GO:0007498; P:mesoderm development; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0090009; P:primitive streak formation; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.150.50; -; 1.
DR InterPro; IPR045688; Ets1_N_flank.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR016311; Transform_prot_C-ets.
DR InterPro; IPR027276; Transform_prot_C-ets-2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; PTHR11849; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF19525; Ets1_N_flank; 1.
DR Pfam; PF02198; SAM_PNT; 1.
DR PIRSF; PIRSF501032; C-ets-2; 1.
DR PIRSF; PIRSF001698; Transforming_factor_C-ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF47769; SSF47769; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR PROSITE; PS51433; PNT; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Proto-oncogene; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..479
FT /note="Protein C-ets-2"
FT /id="PRO_0000204076"
FT DOMAIN 88..173
FT /note="PNT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00762"
FT DNA_BIND 373..453
FT /note="ETS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
SQ SEQUENCE 479 AA; 54540 MW; 91BCD5206972E867 CRC64;
MSEFAIRNMD QVAPVSNMYR GMLKRQPAFD TFDSSNSLFA GYFLSLNEDQ TLQEVPTGFD
STSYESNNCE LPLLTPCSKA VMSQALKDTF SGFTKEQCRL GIPNNPWLWT EQHVCQWLAW
ATNEFSLANV NIHQFLMSGQ DLCNLGKERF LELAPDYVGD ILWEHLEQMI KDSQEKTQDQ
YVESSHLTSV PHWVNNNSLT VNVDQTPYGI QMPGYPKALS YPKPNLLSDI CQTSTGPNLL
SPEQDFSLFP KTQVDAVSVN YCTVNQDFTR SNLNLLIDNS GKLREHESSE SGAESYESSD
SMLQSWNSQS SLVDLQRVPS YESFEDDCSQ SLCMSKPTMS FKDYIQDRSD PVEQGKPVIP
AAILAGFTGS GPIQLWQFLL ELLTDKSCQS FISWTGDGWE FKLADPDEVA RRWGRRKNKP
KMNYEKLSRG LRYYYDKNII HKTSGKRYVY RFVCDLQNLL GYTAEELHAM LGVQPDTED
