ETS4_DROME
ID ETS4_DROME Reviewed; 518 AA.
AC P29775; Q9VB00;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 3.
DT 03-AUG-2022, entry version 171.
DE RecName: Full=DNA-binding protein D-ETS-4;
GN Name=Ets98B; Synonyms=ETS-4; ORFNames=CG5583;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 405-518, FUNCTION, TISSUE SPECIFICITY,
RP AND DEVELOPMENTAL STAGE.
RC STRAIN=Canton-S; TISSUE=Larva;
RX PubMed=1577186; DOI=10.1016/0012-1606(92)90225-6;
RA Chen T., Bunting M., Karim F.D., Thummel C.S.;
RT "Isolation and characterization of five Drosophila genes that encode an
RT ets-related DNA binding domain.";
RL Dev. Biol. 151:176-191(1992).
CC -!- FUNCTION: May have a role in germline development.
CC {ECO:0000269|PubMed:1577186}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Transient high expression in pole cells during
CC embryonic stages 8-11. {ECO:0000269|PubMed:1577186}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout development with lower levels
CC during larval development. {ECO:0000269|PubMed:1577186}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR EMBL; AE014297; AAF56746.2; -; Genomic_DNA.
DR EMBL; M88474; AAA28451.1; -; Genomic_DNA.
DR PIR; S28821; S28821.
DR RefSeq; NP_524535.2; NM_079811.4.
DR AlphaFoldDB; P29775; -.
DR SMR; P29775; -.
DR BioGRID; 68216; 2.
DR DIP; DIP-23688N; -.
DR STRING; 7227.FBpp0084594; -.
DR PaxDb; P29775; -.
DR DNASU; 43334; -.
DR EnsemblMetazoa; FBtr0085224; FBpp0084594; FBgn0005659.
DR GeneID; 43334; -.
DR KEGG; dme:Dmel_CG5583; -.
DR CTD; 43334; -.
DR FlyBase; FBgn0005659; Ets98B.
DR VEuPathDB; VectorBase:FBgn0005659; -.
DR eggNOG; KOG3805; Eukaryota.
DR GeneTree; ENSGT00940000157549; -.
DR InParanoid; P29775; -.
DR OMA; PHQFQAQ; -.
DR OrthoDB; 908495at2759; -.
DR PhylomeDB; P29775; -.
DR BioGRID-ORCS; 43334; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 43334; -.
DR PRO; PR:P29775; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0005659; Expressed in embryonic epidermis (Drosophila) and 21 other tissues.
DR ExpressionAtlas; P29775; baseline and differential.
DR Genevisible; P29775; DM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.150.50; -; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; PTHR11849; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF02198; SAM_PNT; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF47769; SSF47769; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR PROSITE; PS51433; PNT; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..518
FT /note="DNA-binding protein D-ETS-4"
FT /id="PRO_0000204108"
FT DOMAIN 258..344
FT /note="PNT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00762"
FT DNA_BIND 430..513
FT /note="ETS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT REGION 74..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 152..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..106
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 518 AA; 57713 MW; B4B59F5EBB07454C CRC64;
MEYEKMLYMP AASEMPHSPQ LKPHQFQAHT PTDQYSSYAD NFDLSLLPQE SASIPTTVFQ
YNAPQIKVEC AWDSQPIQQQ QQPTAPYTNP SSHQLIPPPA YPHSAYPSPQ SSPLQSEFAA
YGLGRFGGSY DSLNSPSPSL EAVSIKQELH ILPPSPPESN CETPSPRSSC GESIKAEPLD
ADIESLIDLN SLLQQQSLQS PQNLQDTKPD HQLLRECLED TSFQKRHNLK PLALESFIGG
LAEVRGDFEP VISLALEHAK READAICAEL QISQDPNGWS PAQVHAWLRS TLAQFRLPPV
ADLELHFCEN GAALALLSEE EFVRRLPESG STLHAQLEIW KMAYADQPAH QQHSQQSAST
DHWPASYAMP HLDLDYNEDS EDDDDMEADA QVAPLNGSTT SPPATNASNG GTATVKRPNG
GRTGGGGSHI HLWQFLKELL ASPQVNGTAI RWIDRSKGIF KIEDSVRVAK LWGRRKNRPA
MNYDKLSRSI RQYYKKGIMK KTERSQRLVY QFCHPYSQ
