AGRP_PIG
ID AGRP_PIG Reviewed; 134 AA.
AC Q9TU18;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Agouti-related protein;
DE Flags: Precursor;
GN Name=AGRP;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12019634; DOI=10.2527/2002.8051388x;
RA Halverson M.J., Donelan K.J., Granholm N.H., Cheesbrough T.M., Westby C.A.,
RA Marshall D.M.;
RT "Sequencing of the porcine agouti-related protein (AGRP) gene.";
RL J. Anim. Sci. 80:1388-1389(2002).
CC -!- FUNCTION: Plays a role in weight homeostasis. Involved in the control
CC of feeding behavior through the central melanocortin system. Acts as
CC alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP
CC production mediated by stimulation of melanocortin receptors within the
CC hypothalamus and adrenal gland. Has very low activity with MC5R. Is an
CC inverse agonist for MC3R and MC4R being able to suppress their
CC constitutive activity. It promotes MC3R and MC4R endocytosis in an
CC arrestin-dependent manner. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with melanocortin receptors MC3R, MC4R and MC5R.
CC {ECO:0000250|UniProtKB:O00253}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O00253}. Golgi
CC apparatus lumen {ECO:0000250|UniProtKB:O00253}.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin.
CC {ECO:0000250|UniProtKB:O00253}.
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DR EMBL; AF177762; AAF13865.2; -; Genomic_DNA.
DR RefSeq; NP_001011693.1; NM_001011693.1.
DR RefSeq; XP_013853683.1; XM_013998229.1.
DR RefSeq; XP_013853684.1; XM_013998230.1.
DR AlphaFoldDB; Q9TU18; -.
DR SMR; Q9TU18; -.
DR STRING; 9823.ENSSSCP00000002994; -.
DR PaxDb; Q9TU18; -.
DR Ensembl; ENSSSCT00000003073; ENSSSCP00000002994; ENSSSCG00000002775.
DR Ensembl; ENSSSCT00005006187; ENSSSCP00005003568; ENSSSCG00005004181.
DR Ensembl; ENSSSCT00015109310; ENSSSCP00015046454; ENSSSCG00015080413.
DR Ensembl; ENSSSCT00025102770; ENSSSCP00025045512; ENSSSCG00025074577.
DR Ensembl; ENSSSCT00030027169; ENSSSCP00030012100; ENSSSCG00030019682.
DR Ensembl; ENSSSCT00035041982; ENSSSCP00035016785; ENSSSCG00035031706.
DR Ensembl; ENSSSCT00040004181; ENSSSCP00040001315; ENSSSCG00040003344.
DR Ensembl; ENSSSCT00045041948; ENSSSCP00045029124; ENSSSCG00045024624.
DR Ensembl; ENSSSCT00050062839; ENSSSCP00050026978; ENSSSCG00050046187.
DR Ensembl; ENSSSCT00055011086; ENSSSCP00055008754; ENSSSCG00055005697.
DR Ensembl; ENSSSCT00060069922; ENSSSCP00060030150; ENSSSCG00060051379.
DR Ensembl; ENSSSCT00065028988; ENSSSCP00065011837; ENSSSCG00065021799.
DR Ensembl; ENSSSCT00070035263; ENSSSCP00070029450; ENSSSCG00070017867.
DR GeneID; 397275; -.
DR KEGG; ssc:397275; -.
DR CTD; 181; -.
DR VGNC; VGNC:85189; AGRP.
DR eggNOG; ENOG502S7K0; Eukaryota.
DR GeneTree; ENSGT00940000154258; -.
DR HOGENOM; CLU_103790_0_0_1; -.
DR InParanoid; Q9TU18; -.
DR OMA; SWAMLQG; -.
DR OrthoDB; 1404700at2759; -.
DR TreeFam; TF330729; -.
DR Proteomes; UP000008227; Chromosome 6.
DR Proteomes; UP000314985; Chromosome 6.
DR Bgee; ENSSSCG00000002775; Expressed in blood and 4 other tissues.
DR Genevisible; Q9TU18; SS.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0005796; C:Golgi lumen; ISS:UniProtKB.
DR GO; GO:0031779; F:melanocortin receptor binding; IBA:GO_Central.
DR GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
DR GO; GO:0070996; F:type 1 melanocortin receptor binding; IBA:GO_Central.
DR GO; GO:0031781; F:type 3 melanocortin receptor binding; ISS:UniProtKB.
DR GO; GO:0031782; F:type 4 melanocortin receptor binding; ISS:UniProtKB.
DR GO; GO:0008343; P:adult feeding behavior; IBA:GO_Central.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:InterPro.
DR GO; GO:0007218; P:neuropeptide signaling pathway; ISS:UniProtKB.
DR GO; GO:2000253; P:positive regulation of feeding behavior; IBA:GO_Central.
DR GO; GO:0060259; P:regulation of feeding behavior; ISS:UniProtKB.
DR Gene3D; 4.10.760.10; -; 1.
DR InterPro; IPR007733; Agouti.
DR InterPro; IPR027300; Agouti_dom.
DR InterPro; IPR036836; Agouti_dom_sf.
DR PANTHER; PTHR16551; PTHR16551; 1.
DR Pfam; PF05039; Agouti; 1.
DR SMART; SM00792; Agouti; 1.
DR SUPFAM; SSF57055; SSF57055; 1.
DR PROSITE; PS60024; AGOUTI_1; 1.
DR PROSITE; PS51150; AGOUTI_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Golgi apparatus; Knottin; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PROPEP 21..84
FT /evidence="ECO:0000250|UniProtKB:O00253"
FT /id="PRO_0000434046"
FT CHAIN 85..134
FT /note="Agouti-related protein"
FT /id="PRO_0000001036"
FT DOMAIN 89..131
FT /note="Agouti"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00494"
FT REGION 113..115
FT /note="Interaction with melanocortin receptors"
FT /evidence="ECO:0000250"
FT SITE 84..85
FT /note="Cleavage; by PCSK1"
FT /evidence="ECO:0000250|UniProtKB:O00253"
FT DISULFID 89..104
FT /evidence="ECO:0000250|UniProtKB:O00253,
FT ECO:0000255|PROSITE-ProRule:PRU00494"
FT DISULFID 96..110
FT /evidence="ECO:0000250|UniProtKB:O00253,
FT ECO:0000255|PROSITE-ProRule:PRU00494"
FT DISULFID 103..121
FT /evidence="ECO:0000250|UniProtKB:O00253,
FT ECO:0000255|PROSITE-ProRule:PRU00494"
FT DISULFID 107..131
FT /evidence="ECO:0000250|UniProtKB:O00253,
FT ECO:0000255|PROSITE-ProRule:PRU00494"
FT DISULFID 112..119
FT /evidence="ECO:0000250|UniProtKB:O00253,
FT ECO:0000255|PROSITE-ProRule:PRU00494"
SQ SEQUENCE 134 AA; 14681 MW; DA89AC087567889A CRC64;
MLTTMLLSCA LLLAMPTMLG AQIGLAPLEG IGRLDQALFP ELQDLGLQPP LKRTTAERAE
EALLQQAEAK ALAEVLDPEG RKARSPRRCV RLHESCLGHQ VPCCDPCATC YCRFFNAFCY
CRKLGTATNP CSRT
