ETS5_CAEEL
ID ETS5_CAEEL Reviewed; 208 AA.
AC Q18579;
DT 05-JUL-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=ETS domain-containing transcription factor ets-5 {ECO:0000305};
GN Name=ets-5 {ECO:0000312|WormBase:C42D8.4a};
GN ORFNames=C42D8.4 {ECO:0000312|WormBase:C42D8.4a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=22479504; DOI=10.1371/journal.pone.0034014;
RA Brandt J.P., Aziz-Zaman S., Juozaityte V., Martinez-Velazquez L.A.,
RA Petersen J.G., Pocock R., Ringstad N.;
RT "A single gene target of an ETS-family transcription factor determines
RT neuronal CO2-chemosensitivity.";
RL PLoS ONE 7:E34014-E34014(2012).
RN [2] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3] {ECO:0000305}
RP FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=21954162; DOI=10.1534/genetics.111.133835;
RA Guillermin M.L., Castelletto M.L., Hallem E.A.;
RT "Differentiation of carbon dioxide-sensing neurons in Caenorhabditis
RT elegans requires the ETS-5 transcription factor.";
RL Genetics 189:1327-1339(2011).
RN [4] {ECO:0000305}
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=28193866; DOI=10.1073/pnas.1610673114;
RA Juozaityte V., Pladevall-Morera D., Podolska A., Noergaard S., Neumann B.,
RA Pocock R.;
RT "The ETS-5 transcription factor regulates activity states in Caenorhabditis
RT elegans by controlling satiety.";
RL Proc. Natl. Acad. Sci. U.S.A. 114:E1651-E1658(2017).
RN [5]
RP FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=30890567; DOI=10.1242/dev.168153;
RA Brandt J.P., Rossillo M., Du Z., Ichikawa D., Barnes K., Chen A., Noyes M.,
RA Bao Z., Ringstad N.;
RT "Lineage context switches the function of a C. elegans Pax6 homolog in
RT determining a neuronal fate.";
RL Development 146:0-0(2019).
CC -!- FUNCTION: Transcription factor that plays a role in the differentiation
CC and function of the CO(2)- and O(2)-sensing BAG neurons
CC (PubMed:21954162, PubMed:22479504, PubMed:30890567). The BAG neurons
CC are required for the behavioral avoidance of environmental CO(2) and
CC the sensing of decreased O(2) levels (PubMed:21954162, PubMed:22479504,
CC PubMed:28193866). Promotes the expression of genes that play a role in
CC CO(2)- and O(2)-sensing and in egg-laying in the BAG neurons
CC (PubMed:21954162). Positively regulates the transcription of the
CC receptor-type guanylate cyclase gcy-9, which is a critical component of
CC the CO(2) transduction pathway, in the BAG neurons (PubMed:22479504).
CC May mediate transcriptional activation by binding to the motif 5'-
CC ACTTCCG-3' (PubMed:22479504, PubMed:30890567). Acts in the BAG and ASG
CC neurons to regulate intestinal fat levels and to promote exploratory
CC behavior, possibly by regulating neuropeptidergic signaling
CC (PubMed:28193866). {ECO:0000269|PubMed:21954162,
CC ECO:0000269|PubMed:22479504, ECO:0000269|PubMed:28193866,
CC ECO:0000269|PubMed:30890567}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237,
CC ECO:0000269|PubMed:22479504}.
CC -!- TISSUE SPECIFICITY: Expressed in a subset of head neurons, including
CC the BAG sensory neurons, the AWA amphid neurons and the ASG sensory
CC neurons. {ECO:0000269|PubMed:21954162, ECO:0000269|PubMed:22479504,
CC ECO:0000269|PubMed:28193866, ECO:0000269|PubMed:30890567}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout development and in adult
CC animals (PubMed:21954162). First expressed in the embryonic BAG neurons
CC (PubMed:30890567). {ECO:0000269|PubMed:21954162,
CC ECO:0000269|PubMed:30890567}.
CC -!- DISRUPTION PHENOTYPE: Lack of CO(2) avoidance behavior
CC (PubMed:21954162, PubMed:22479504). Down-regulation of genes required
CC for BAG neuron differentiation and function (PubMed:21954162,
CC PubMed:22479504). Reduction in exploratory behavior and an increase of
CC animals in the quiescent state (PubMed:28193866). Unable to sense
CC downsteps of O(2) (PubMed:28193866). Increased intestinal fat storage
CC (PubMed:28193866). {ECO:0000269|PubMed:21954162,
CC ECO:0000269|PubMed:22479504, ECO:0000269|PubMed:28193866}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000255|RuleBase:RU004019}.
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DR EMBL; BX284606; CCD65565.1; -; Genomic_DNA.
DR PIR; T15790; T15790.
DR RefSeq; NP_508865.1; NM_076464.1.
DR AlphaFoldDB; Q18579; -.
DR SMR; Q18579; -.
DR IntAct; Q18579; 1.
DR STRING; 6239.C42D8.4b; -.
DR PaxDb; Q18579; -.
DR EnsemblMetazoa; C42D8.4a.1; C42D8.4a.1; WBGene00016600.
DR EnsemblMetazoa; C42D8.4a.2; C42D8.4a.2; WBGene00016600.
DR EnsemblMetazoa; C42D8.4a.3; C42D8.4a.3; WBGene00016600.
DR EnsemblMetazoa; C42D8.4a.4; C42D8.4a.4; WBGene00016600.
DR GeneID; 180778; -.
DR UCSC; C42D8.4; c. elegans.
DR CTD; 180778; -.
DR WormBase; C42D8.4a; CE04205; WBGene00016600; ets-5.
DR eggNOG; KOG3806; Eukaryota.
DR GeneTree; ENSGT00940000165272; -.
DR HOGENOM; CLU_045216_3_0_1; -.
DR PhylomeDB; Q18579; -.
DR PRO; PR:Q18579; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00016600; Expressed in larva and 3 other tissues.
DR ExpressionAtlas; Q18579; baseline.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; PTHR11849; 1.
DR Pfam; PF00178; Ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..208
FT /note="ETS domain-containing transcription factor ets-5"
FT /id="PRO_0000441024"
FT DNA_BIND 35..115
FT /note="ETS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 208 AA; 22664 MW; 1FF92243901ED2E9 CRC64;
MQYASALSRI PSSNSTSASK GPMAIALSAT GTGQIQLWQF LLELLADAVN AHCIAWEGSN
GEFKLVDPDE VARKWGERKS KPNMNYDKLS RALRYYYDKN IMTKVQGKRY AYKFDFQGLA
QACQSAILTN GGNPNGDLSS TVHSLSPYTN QVLPIGVTSR LSTSMSSYHS ILSSTSSTSS
NQIIPPSTAT YWSTPQSSLT YTGMPSSY
