ETS6_DROME
ID ETS6_DROME Reviewed; 475 AA.
AC P29776; Q9VPQ9;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2001, sequence version 2.
DT 03-AUG-2022, entry version 177.
DE RecName: Full=DNA-binding protein D-ETS-6;
GN Name=Ets21C; Synonyms=ETS-6; ORFNames=CG2914;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 235-352, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC STRAIN=Canton-S; TISSUE=Larva;
RX PubMed=1577186; DOI=10.1016/0012-1606(92)90225-6;
RA Chen T., Bunting M., Karim F.D., Thummel C.S.;
RT "Isolation and characterization of five Drosophila genes that encode an
RT ets-related DNA binding domain.";
RL Dev. Biol. 151:176-191(1992).
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Embryonic ventral nervous system and 1 pair of
CC neurons in each thoracic segment. {ECO:0000269|PubMed:1577186}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout development.
CC {ECO:0000269|PubMed:1577186}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA28452.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AE014134; AAF51484.1; -; Genomic_DNA.
DR EMBL; M88475; AAA28452.1; ALT_FRAME; Genomic_DNA.
DR PIR; S28823; S28823.
DR RefSeq; NP_001285547.1; NM_001298618.1.
DR RefSeq; NP_001285548.1; NM_001298619.1.
DR RefSeq; NP_523445.1; NM_078721.2.
DR AlphaFoldDB; P29776; -.
DR SMR; P29776; -.
DR BioGRID; 59485; 19.
DR IntAct; P29776; 12.
DR STRING; 7227.FBpp0077739; -.
DR PaxDb; P29776; -.
DR DNASU; 33229; -.
DR EnsemblMetazoa; FBtr0078079; FBpp0077739; FBgn0005660.
DR EnsemblMetazoa; FBtr0344014; FBpp0310465; FBgn0005660.
DR EnsemblMetazoa; FBtr0345429; FBpp0311554; FBgn0005660.
DR GeneID; 33229; -.
DR KEGG; dme:Dmel_CG2914; -.
DR CTD; 33229; -.
DR FlyBase; FBgn0005660; Ets21C.
DR VEuPathDB; VectorBase:FBgn0005660; -.
DR eggNOG; KOG3806; Eukaryota.
DR GeneTree; ENSGT00940000165272; -.
DR HOGENOM; CLU_042579_0_0_1; -.
DR InParanoid; P29776; -.
DR OMA; TCISWEG; -.
DR OrthoDB; 1113327at2759; -.
DR PhylomeDB; P29776; -.
DR BioGRID-ORCS; 33229; 0 hits in 3 CRISPR screens.
DR ChiTaRS; Ets21C; fly.
DR GenomeRNAi; 33229; -.
DR PRO; PR:P29776; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0005660; Expressed in embryonic ventral nervous system (Drosophila) and 13 other tissues.
DR ExpressionAtlas; P29776; baseline and differential.
DR Genevisible; P29776; DM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IMP:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.150.50; -; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; PTHR11849; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF02198; SAM_PNT; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF47769; SSF47769; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR PROSITE; PS51433; PNT; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..475
FT /note="DNA-binding protein D-ETS-6"
FT /id="PRO_0000204109"
FT DOMAIN 132..219
FT /note="PNT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00762"
FT DNA_BIND 255..335
FT /note="ETS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT REGION 42..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 350..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..125
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..394
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 475 AA; 51802 MW; 0D382C41C03B1502 CRC64;
MAILQNSRQS HKQLPIISQT IRSAWCQQRP INAMHQDVRQ KSIGSGNETK LEAKETEVPT
NRRRRRRRCS SSSTSDSSAS SYSSTDSDSG SSTSSSSIRS QLPALNLPVP LPLATPTPPA
VSSPHQAPSP RRNSSDSNRS VSPVEVPVDP HAWTPEDIAS WVRWATRKFK LDPEPDIDRF
PKDAQELCDL SRADFWVCAG SRRGGMLLAQ HFAISLYHAT GRETSPMLND DEPNPYQLLN
AASHRLVAQG SGGQIQLWQF LLELLADSSN ANAISWEGQS GEFRLIDPDE VARRWGERKA
KPNMNYDKLS RALRYYYDKN IMTKVHGKRY AYKFDFHGLM AACQAQAQGG DPASSMLGSY
NHHAGGAMQL GRHPPPLHHH PQHSHPHHQL GQPHFLHPHH SSPASNSSSL GFPSSSTASS
QASPGQAPAS SSASTSNFTA PFQGGTAGVD PARTSTSSAG NYDQGPVTPT TNAFN
