ETS7_CAEEL
ID ETS7_CAEEL Reviewed; 218 AA.
AC O01519;
DT 25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=ETS domain-containing protein ets-7 {ECO:0000305};
DE AltName: Full=ETS class transcription factor ets-7 {ECO:0000312|WormBase:F19F10.5};
GN Name=ets-7 {ECO:0000312|WormBase:F19F10.5};
GN ORFNames=F19F10.5 {ECO:0000312|WormBase:F19F10.5};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, AND INDUCTION.
RX PubMed=27514077; DOI=10.18632/aging.101011;
RA Nguyen T.T., Caito S.W., Zackert W.E., West J.D., Zhu S., Aschner M.,
RA Fessel J.P., Roberts L.J. II;
RT "Scavengers of reactive gamma-ketoaldehydes extend Caenorhabditis elegans
RT lifespan and healthspan through protein-level interactions with SIR-2.1 and
RT ETS-7.";
RL Aging (Albany NY) 8:1759-1780(2016).
CC -!- FUNCTION: Probable transcription factor (By similarity). Involved in
CC responses to oxidative stress (PubMed:27514077).
CC {ECO:0000250|UniProtKB:P41212, ECO:0000269|PubMed:27514077}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
CC -!- INDUCTION: Up-regulated by salicylamine. {ECO:0000269|PubMed:27514077}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000255|RuleBase:RU004019}.
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DR EMBL; BX284605; CCD67764.1; -; Genomic_DNA.
DR RefSeq; NP_504947.2; NM_072546.2.
DR AlphaFoldDB; O01519; -.
DR SMR; O01519; -.
DR IntAct; O01519; 2.
DR STRING; 6239.F19F10.5; -.
DR PaxDb; O01519; -.
DR EnsemblMetazoa; F19F10.5.1; F19F10.5.1; WBGene00017601.
DR GeneID; 184687; -.
DR KEGG; cel:CELE_F19F10.5; -.
DR UCSC; F19F10.5; c. elegans.
DR CTD; 184687; -.
DR WormBase; F19F10.5; CE43542; WBGene00017601; ets-7.
DR eggNOG; KOG3806; Eukaryota.
DR GeneTree; ENSGT00970000196452; -.
DR HOGENOM; CLU_109510_0_0_1; -.
DR InParanoid; O01519; -.
DR OMA; KANEPMR; -.
DR OrthoDB; 1806890at2759; -.
DR PhylomeDB; O01519; -.
DR Reactome; R-CEL-8939245; RUNX1 regulates transcription of genes involved in BCR signaling.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00017601; Expressed in embryo and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0001709; P:cell fate determination; IEA:InterPro.
DR GO; GO:0045596; P:negative regulation of cell differentiation; IEA:InterPro.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR033077; Pokkuri.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; PTHR11849; 1.
DR PANTHER; PTHR11849:SF201; PTHR11849:SF201; 1.
DR Pfam; PF00178; Ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..218
FT /note="ETS domain-containing protein ets-7"
FT /id="PRO_0000455600"
FT DNA_BIND 12..93
FT /note="ETS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT REGION 131..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 218 AA; 24461 MW; F5112D581CDE959F CRC64;
MSSKRTSPNG KQRLLNFLRG LLEDDSHSDL ITWSNKDTLE FQMLKPHKVA ELWGAATGNP
GMNYDKMSRG LRYFYTNNTL KKVKGKDSRY CFLDTPLLAP FPDFFPKANE PMRRVPLFSI
ENLLASSEET TSNFSLQSSP SSSSNSSSAR TMSATSSPTS SLEDVINPPV LIDPFQMQMA
HITQTFLATQ LPALQAFPMQ LQLQFLKTLL PTLFPNNN
