ID   ETT1_ASHGO              Reviewed;         411 AA.
AC   Q74ZA4;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Enhancer of translation termination 1;
GN   Name=ETT1; OrderedLocusNames=AGR299W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Required for correct translation termination and probably
CC       involved in regulation of hypoxic gene expression. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ETT1 family. {ECO:0000305}.
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DR   EMBL; AE016820; AAS54789.1; -; Genomic_DNA.
DR   RefSeq; NP_986965.1; NM_212027.1.
DR   AlphaFoldDB; Q74ZA4; -.
DR   SMR; Q74ZA4; -.
DR   STRING; 33169.AAS54789; -.
DR   PRIDE; Q74ZA4; -.
DR   EnsemblFungi; AAS54789; AAS54789; AGOS_AGR299W.
DR   GeneID; 4623268; -.
DR   KEGG; ago:AGOS_AGR299W; -.
DR   eggNOG; ENOG502QPHX; Eukaryota.
DR   HOGENOM; CLU_050427_0_0_1; -.
DR   InParanoid; Q74ZA4; -.
DR   OMA; GIVHECD; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:2000640; P:positive regulation of SREBP signaling pathway; IBA:GO_Central.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   GO; GO:0006415; P:translational termination; IBA:GO_Central.
DR   InterPro; IPR024318; Nro1/ETT1.
DR   PANTHER; PTHR28290; PTHR28290; 1.
DR   Pfam; PF12753; Nro1; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation;
KW   Translation regulation.
FT   CHAIN           1..411
FT                   /note="Enhancer of translation termination 1"
FT                   /id="PRO_0000406609"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..43
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   411 AA;  46381 MW;  501011C82AC8CA98 CRC64;
     MTKRPLGLGK KNKQKRHKPD EGADGKKEST PLDQIHVEVE GGGDPEDSVV QLKALWRNYL
     QSEREDERVL NGIVHECDRL LRNREQEGIE LGEDFHSIYA LALSELAIFR TEEKGQAGRE
     SVGEFFDAAA ERVDMGLQHF PASDVLALAK AKIIFQRIPL QYVSQLSPNN SEGADVGLQQ
     LLEEGKSSFR VVAQDPLAVS EPLEIFSDLL EIIANFGRED EIDEGLDSDA EDEPEEVELP
     ESHPLYELRQ HLPEHAEWLQ QQLLALFKVL EKPNAEEEES EATKFYRKIA NKLGQSYLDA
     AAEPSIVFTT LTYETEDPSA EDEQKAQEAQ RVAQGLTERA IEFFKEAESA DDPQTWVDTA
     EVFISLGNLQ ENESETQEML YKQAEEKMVR ANKATNGKYK HILDTLLDSK T