ID   ETT1_CANAL              Reviewed;         421 AA.
AC   Q5A0J9; A0A1D8PGR2;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Enhancer of translation termination 1;
GN   Name=ETT1; OrderedLocusNames=CAALFM_C202930CA;
GN   ORFNames=CaO19.13234, CaO19.5812;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Required for correct translation termination and probably
CC       involved in regulation of hypoxic gene expression. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ETT1 family. {ECO:0000305}.
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DR   EMBL; CP017624; AOW27330.1; -; Genomic_DNA.
DR   RefSeq; XP_715353.1; XM_710260.2.
DR   AlphaFoldDB; Q5A0J9; -.
DR   SMR; Q5A0J9; -.
DR   STRING; 237561.Q5A0J9; -.
DR   PRIDE; Q5A0J9; -.
DR   GeneID; 3643015; -.
DR   KEGG; cal:CAALFM_C202930CA; -.
DR   CGD; CAL0000200223; orf19.13234.
DR   VEuPathDB; FungiDB:C2_02930C_A; -.
DR   eggNOG; ENOG502QPHX; Eukaryota.
DR   HOGENOM; CLU_050427_0_0_1; -.
DR   InParanoid; Q5A0J9; -.
DR   OrthoDB; 1255094at2759; -.
DR   PRO; PR:Q5A0J9; -.
DR   Proteomes; UP000000559; Chromosome 2.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:2000640; P:positive regulation of SREBP signaling pathway; IBA:GO_Central.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   GO; GO:0006415; P:translational termination; IBA:GO_Central.
DR   InterPro; IPR024318; Nro1/ETT1.
DR   PANTHER; PTHR28290; PTHR28290; 1.
DR   Pfam; PF12753; Nro1; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation;
KW   Translation regulation.
FT   CHAIN           1..421
FT                   /note="Enhancer of translation termination 1"
FT                   /id="PRO_0000406610"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          230..259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..29
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        236..253
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   421 AA;  48230 MW;  3E3947A3029F2851 CRC64;
     MAKRTLGLAK AAKAKKQKKE QEHQESSASP DEESSSSNQL TIELPEEIDA NDEISQLKGL
     HKTYLQSERD NELLVNGIIH ECDRLLREND SENKQPLPAV FHAIYAIALA ELSKFHTEEL
     DKVKEFFIAA LERVESGLEK NPNDINLLVA KTKILLDQIS LQYIAPLTLE SDVKELDKEI
     DELLDAALSV YESVEARAKE LKDYSIFDDS ETLDILEALD DILDIVDNFG KENQGDDGSD
     EDDEEDDDEE EKSVELAETH PLYKIKNSDK YDQWWRDHTH LYLDNLEKLE NGSPELKREV
     CHRLGQSYLQ ESEVPYSVFT KLKYDDEYDG IEELEGLTEK EAQKISQELI TKALDYLKQA
     KDEEDPETWV SIAEAMISLG NLYEVDSKEQ EDLYLEAEKI LKRANNVTNG KFQEELDNLL
     P