ID   ETT1_CANAW              Reviewed;         421 AA.
AC   C4YJP2;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Enhancer of translation termination 1;
GN   Name=ETT1; ORFNames=CAWG_04060;
OS   Candida albicans (strain WO-1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294748;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WO-1;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Required for correct translation termination and probably
CC       involved in regulation of hypoxic gene expression. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ETT1 family. {ECO:0000305}.
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DR   EMBL; CH672350; EEQ45726.1; -; Genomic_DNA.
DR   AlphaFoldDB; C4YJP2; -.
DR   SMR; C4YJP2; -.
DR   STRING; 5476.C4YJP2; -.
DR   EnsemblFungi; EEQ45726; EEQ45726; CAWG_04060.
DR   VEuPathDB; FungiDB:CAWG_04060; -.
DR   HOGENOM; CLU_050427_0_0_1; -.
DR   OMA; GIVHECD; -.
DR   Proteomes; UP000001429; Chromosome 2, Supercontig 1.5.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   InterPro; IPR024318; Nro1/ETT1.
DR   PANTHER; PTHR28290; PTHR28290; 1.
DR   Pfam; PF12753; Nro1; 1.
PE   3: Inferred from homology;
KW   Nucleus; Transcription; Transcription regulation; Translation regulation.
FT   CHAIN           1..421
FT                   /note="Enhancer of translation termination 1"
FT                   /id="PRO_0000406611"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          230..259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..29
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        236..253
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   421 AA;  48240 MW;  9B4C2A5CB46A36B6 CRC64;
     MAKRTLGLAK AAKAKKQKKE QEHQEISASP DEESSSSNQL TIELPEEIDA NNEISQLKGL
     HKTYLQSERD NELLVNGIIH ECDRLLREND SENKQPLPAV FHAIYAIALA ELSKFHTEEL
     DKVKEFFIAA LERVELGLEK NPNDINLLVA KTKILLDQIS LQYIAPLTLE SDVKELDKEI
     DELLDAALSV YESVEARAKE LKDYSIFDDS ETLDILEALD DILDIVDNFG KENQGDDGSD
     EDDDEDDDEE EKSVELAETH PLYKIKNSDK YDQWWRDHTH LYLDNLEKLE NGSPELKREV
     CHRLGQSYLQ ESEVPYSVFT TLKYDDEYDG IEELEGLTEK EAQKISQELI TKALDYLKQA
     KDEEDPETWV SIAEAMISLG NLYEVDSKEQ EDLYLEAEKI LKRANNVTNG KFQEELDNLL
     P