ID   ETT1_CANTT              Reviewed;         435 AA.
AC   C5M685;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Enhancer of translation termination 1;
GN   Name=ETT1; ORFNames=CTRG_01366;
OS   Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-3404 / T1;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Required for correct translation termination and probably
CC       involved in regulation of hypoxic gene expression. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ETT1 family. {ECO:0000305}.
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DR   EMBL; GG692396; EER34505.1; -; Genomic_DNA.
DR   RefSeq; XP_002547060.1; XM_002547014.1.
DR   AlphaFoldDB; C5M685; -.
DR   SMR; C5M685; -.
DR   STRING; 5482.XP_002547060.1; -.
DR   EnsemblFungi; EER34505; EER34505; CTRG_01366.
DR   GeneID; 8296427; -.
DR   KEGG; ctp:CTRG_01366; -.
DR   VEuPathDB; FungiDB:CTRG_01366; -.
DR   eggNOG; ENOG502QPHX; Eukaryota.
DR   HOGENOM; CLU_050427_0_0_1; -.
DR   OrthoDB; 1255094at2759; -.
DR   Proteomes; UP000002037; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   GO; GO:0006415; P:translational termination; IEA:EnsemblFungi.
DR   InterPro; IPR024318; Nro1/ETT1.
DR   PANTHER; PTHR28290; PTHR28290; 1.
DR   Pfam; PF12753; Nro1; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation;
KW   Translation regulation.
FT   CHAIN           1..435
FT                   /note="Enhancer of translation termination 1"
FT                   /id="PRO_0000406614"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          239..263
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..35
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        240..263
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   435 AA;  50088 MW;  CC6E1E8ABB400B18 CRC64;
     MAKRTLGLAK AAKAKKQKRE EKSESPEKDS GNEEEQLTVE LPEGATDEIS QLIGLHQTYL
     QSERDNELLV NGIIHECDRL LRSNEDGKEE LPAIFHSIYA TALAELSKFV EEEEEEEKKE
     KEEQESDKKI KEFFDAALER IEIGLEKHPN DVNLLIAKSK ILIDQIVLQY ISPLSVDSKK
     KEIEVEVEKL LDTALEIYEL AEVKANESKN YEVFNDLETL DILQALDDLL DIVDNFGKNN
     LEEEEEDEDE ETEKDNGDDE DEVEIELTED HPLYVIKTSD KYNQWWRDHT HTYLDNLKKL
     DSKDVLPEVL REVNHRLGQS YLQESEIPTT VFTTLKYDDE YDGAKELEGL TVEEAQKISQ
     DLISKALKYL KGAKDEEDPE TWVDIAEAMI TLGNLHDIDS KEQEDLYKEA EEILKKANNA
     TNGKFKDILE NLLEN