AGRV1_DANRE
ID AGRV1_DANRE Reviewed; 6199 AA.
AC Q6JAN0;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Adhesion G-protein coupled receptor V1 {ECO:0000305};
DE EC=3.4.-.- {ECO:0000250|UniProtKB:Q8VHN7};
DE AltName: Full=G-protein coupled receptor 98;
DE AltName: Full=Monogenic audiogenic seizure susceptibility protein 1 homolog;
DE AltName: Full=Very large G-protein coupled receptor 1;
DE Flags: Precursor;
GN Name=adgrv1; Synonyms=gpr98, mass1, vlgr1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX PubMed=15979825; DOI=10.1016/j.gene.2005.05.015;
RA Gibert Y., McMillan D.R., Kayes-Wandover K., Meyer A., Begemann G.,
RA White P.C.;
RT "Analysis of the very large G-protein coupled receptor gene
RT (Vlgr1/Mass1/USH2C) in zebrafish.";
RL Gene 353:200-206(2005).
CC -!- FUNCTION: Receptor that may have an important role in the development
CC of the sensory nervous system. {ECO:0000250|UniProtKB:Q8VHN7,
CC ECO:0000250|UniProtKB:Q8WXG9}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8VHN7};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8VHN7}. Cell
CC projection, stereocilium membrane {ECO:0000250|UniProtKB:Q8VHN7}.
CC Photoreceptor inner segment {ECO:0000250|UniProtKB:Q8VHN7}.
CC -!- DEVELOPMENTAL STAGE: Weak expression was first detected at 20 hours
CC post-fertilization (hpf) in the ventral diencephalon. At 24-26 hpf,
CC expression is prominent in the prospective fore-, mid- and hindbrain
CC including the ventral part of the epiphysis. Expression is not detected
CC outside of the central nervous system (CNS) at this stage. At 48 hpf
CC and 72 hpf, expression is detected in the posterior dorsal tegmentum,
CC the mid-hindbrain boundary and in the lower rhombic lip. Expression in
CC the eye is associated with the optic nerve. Outside the CNS, expressed
CC in the anteriorpronephric duct. {ECO:0000269|PubMed:15979825}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY540131; AAT07468.1; -; mRNA.
DR STRING; 7955.ENSDARP00000020853; -.
DR PaxDb; Q6JAN0; -.
DR PRIDE; Q6JAN0; -.
DR ZFIN; ZDB-GENE-040624-6; adgrv1.
DR eggNOG; KOG1306; Eukaryota.
DR eggNOG; KOG4193; Eukaryota.
DR InParanoid; Q6JAN0; -.
DR PhylomeDB; Q6JAN0; -.
DR PRO; PR:Q6JAN0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0001917; C:photoreceptor inner segment; IEA:UniProtKB-SubCell.
DR GO; GO:0032420; C:stereocilium; IBA:GO_Central.
DR GO; GO:0060171; C:stereocilium membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0010855; F:adenylate cyclase inhibitor activity; ISS:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISS:UniProtKB.
DR GO; GO:0001965; F:G-protein alpha-subunit binding; ISS:UniProtKB.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0071277; P:cellular response to calcium ion; ISS:UniProtKB.
DR GO; GO:0042462; P:eye photoreceptor cell development; IGI:ZFIN.
DR GO; GO:0007194; P:negative regulation of adenylate cyclase activity; ISS:UniProtKB.
DR GO; GO:0010739; P:positive regulation of protein kinase A signaling; ISS:UniProtKB.
DR GO; GO:0090037; P:positive regulation of protein kinase C signaling; ISS:UniProtKB.
DR GO; GO:0031647; P:regulation of protein stability; ISS:UniProtKB.
DR GO; GO:0097264; P:self proteolysis; ISS:UniProtKB.
DR GO; GO:0007605; P:sensory perception of sound; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.40.2030; -; 35.
DR InterPro; IPR026919; ADGRV1.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR009039; EAR.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR006558; LamG-like.
DR InterPro; IPR003609; Pan_app.
DR PANTHER; PTHR46682; PTHR46682; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF03160; Calx-beta; 37.
DR SMART; SM00237; Calx_beta; 19.
DR SMART; SM00560; LamGL; 1.
DR SUPFAM; SSF141072; SSF141072; 38.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50912; EAR; 6.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 2: Evidence at transcript level;
KW Calcium; Cell membrane; Cell projection; Developmental protein;
KW G-protein coupled receptor; Hydrolase; Membrane; Receptor;
KW Reference proteome; Repeat; Signal; Transducer; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..6199
FT /note="Adhesion G-protein coupled receptor V1"
FT /id="PRO_0000232737"
FT TOPO_DOM 24..5803
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 5804..5824
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 5825..5834
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 5835..5855
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 5856..5864
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 5865..5885
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 5886..5908
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 5909..5929
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 5930..5954
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 5955..5975
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 5976..6001
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 6002..6022
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 6023..6025
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 6026..6046
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 6047..6199
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 24..109
FT /note="Calx-beta 1"
FT /evidence="ECO:0000305"
FT DOMAIN 126..230
FT /note="Calx-beta 2"
FT /evidence="ECO:0000255"
FT DOMAIN 249..355
FT /note="Calx-beta 3"
FT /evidence="ECO:0000255"
FT DOMAIN 380..480
FT /note="Calx-beta 4"
FT /evidence="ECO:0000305"
FT DOMAIN 637..737
FT /note="Calx-beta 5"
FT /evidence="ECO:0000305"
FT DOMAIN 753..853
FT /note="Calx-beta 6"
FT /evidence="ECO:0000305"
FT DOMAIN 869..972
FT /note="Calx-beta 7"
FT /evidence="ECO:0000305"
FT DOMAIN 997..1083
FT /note="Calx-beta 8"
FT /evidence="ECO:0000255"
FT DOMAIN 1099..1199
FT /note="Calx-beta 9"
FT /evidence="ECO:0000305"
FT DOMAIN 1434..1534
FT /note="Calx-beta 10"
FT /evidence="ECO:0000305"
FT DOMAIN 1563..1655
FT /note="Calx-beta 11"
FT /evidence="ECO:0000255"
FT DOMAIN 1835..1937
FT /note="Calx-beta 12"
FT /evidence="ECO:0000305"
FT DOMAIN 1963..2063
FT /note="Calx-beta 13"
FT /evidence="ECO:0000255"
FT DOMAIN 2092..2190
FT /note="Calx-beta 14"
FT /evidence="ECO:0000255"
FT DOMAIN 2208..2308
FT /note="Calx-beta 15"
FT /evidence="ECO:0000255"
FT DOMAIN 2425..2525
FT /note="Calx-beta 16"
FT /evidence="ECO:0000305"
FT DOMAIN 2582..2659
FT /note="Calx-beta 17"
FT /evidence="ECO:0000255"
FT DOMAIN 2673..2773
FT /note="Calx-beta 18"
FT /evidence="ECO:0000305"
FT DOMAIN 2814..2908
FT /note="Calx-beta 19"
FT /evidence="ECO:0000255"
FT DOMAIN 2931..3029
FT /note="Calx-beta 20"
FT /evidence="ECO:0000255"
FT DOMAIN 3054..3154
FT /note="Calx-beta 21"
FT /evidence="ECO:0000305"
FT REPEAT 3239..3284
FT /note="EAR 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT REPEAT 3285..3333
FT /note="EAR 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT REPEAT 3336..3372
FT /note="EAR 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT REPEAT 3374..3420
FT /note="EAR 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT REPEAT 3422..3467
FT /note="EAR 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT REPEAT 3471..3513
FT /note="EAR 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT DOMAIN 3562..3605
FT /note="Calx-beta 22"
FT /evidence="ECO:0000255"
FT DOMAIN 3619..3719
FT /note="Calx-beta 23"
FT /evidence="ECO:0000305"
FT DOMAIN 3778..3854
FT /note="Calx-beta 24"
FT /evidence="ECO:0000255"
FT DOMAIN 3916..3985
FT /note="Calx-beta 25"
FT /evidence="ECO:0000255"
FT DOMAIN 4000..4103
FT /note="Calx-beta 26"
FT /evidence="ECO:0000255"
FT DOMAIN 4120..4220
FT /note="Calx-beta 27"
FT /evidence="ECO:0000305"
FT DOMAIN 4247..4335
FT /note="Calx-beta 28"
FT /evidence="ECO:0000255"
FT DOMAIN 4371..4471
FT /note="Calx-beta 29"
FT /evidence="ECO:0000255"
FT DOMAIN 4493..4593
FT /note="Calx-beta 30"
FT /evidence="ECO:0000305"
FT DOMAIN 4615..4715
FT /note="Calx-beta 31"
FT /evidence="ECO:0000305"
FT DOMAIN 4993..5076
FT /note="Calx-beta 32"
FT /evidence="ECO:0000255"
FT DOMAIN 5125..5225
FT /note="Calx-beta 33"
FT /evidence="ECO:0000305"
FT DOMAIN 5260..5360
FT /note="Calx-beta 34"
FT /evidence="ECO:0000305"
FT DOMAIN 5748..5797
FT /note="GPS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00098"
FT SITE 5785..5786
FT /note="Cleavage; by autolysis"
FT /evidence="ECO:0000250|UniProtKB:Q8VHN7"
SQ SEQUENCE 6199 AA; 674630 MW; 893D5E4E933CD055 CRC64;
MPAVLALSGL LLMLLTVSVR SESAELRFQG QTQFVVNESS RAIVRLVVER VGDPINVTAL
VLLQGDDTGD FEATTAAAFL LSSESSKTIF IAVKDDDIPE ADETFVFILR LQSSSNGVTV
GTPNTATITI LSNDNAFGII SFNSSSLITV EESKGRSQYV PLTLLREKGT YGTVTVNFEI
FGGPNPASED LSPDMGNITF PPGRSVVVFS IMIQDDKLPE DDEIFTVQLT EAAGGALLNP
NRSSVQIKIS RNDAPIRFSK STLVVPENIG VISLTVTRGR TEDGLLIGSD DKTVSVAYAI
ITGNGAASAT PLTDFVDLQT ERMVVFLPGV HEADLRFSIR DDNIPEIAES FQVVLLEETL
LGDAVLVTPS LTLVTIEPND KPYGVLSISP SPIQPHIINE DLNLIYEGMI IVRNGGTHGA
VSVQWNITRN STDRSPVSAD LNPAAGTLRF SEGQMSAVLP LNITQDSLPE EAEAFLLKLI
PGSVQGGAEV DEPMEMVFFI QDSDDVYGRF GFHPRENQSI QSQPEGRFLS LSFLREGGTL
GEVRLTLTAL YIPARPLDPS RARDGVLNGT SVNTVLFSSG QSRAQLILPI RNDAFLQNGA
HFRIQLDSVE LVNITPPIPS MSPRFAGALN ISLIITPDIA NGEIGFTSNQ TVVALEPEDS
NSSLITLQLR RDGTDGQAVV FWSLRPTGEN KEDVTKGDIS PFTGSVTFLS GQSEAVINLT
VLADNIPEIN ETIILTLDRT NVDNQILKPG FTSREIVILE NDDPGGVFEF SPVSKGPWFI
NEGETVELRV IRAQGQLLNQ LIRYTVIPSG TAQFYGATGI LEFQPGEREV MVALVAKPDG
IPELDETFSV VLSSYSTPAS RLGNRREVNI TVRKSDDPFG VIEFIQPDLD FTINESKALG
CLLSILPPLE KSRGRFGNVS IFWILEPTYS GDVKPVQGEI VFAEGEYQKN LTLSSVADEI
PEKTENFTIT LLNATGGARL GNILSARLSI RANDDPIYFA EPVGQRVREG GVANFTILRA
GLANFVTTVN YRFEYGDTSS EDFIPESNDT MLVFHFGEWM KNISVAVVDD NIPETDEPFY
IVLFNATGDA VVYGQITATV VIEANDDANG IFSLDSAQKP GEEGKTNNFY VLRDRGHFGN
VTIYWQLFAN DTPLEPYQEF VNTSGFITFR TGEKTKPIVL EVISDKLPEF NEFYELRLMN
VSGGYPGEGG KLANRDLNAS VLIPFNDDPF GVFAIAPDSL EREVAEDVLS VNDMTSVTSL
TILRQQGTFG DVRVAWEILS GAFPRGLPPM EDLILMASFP SAVELQPHSR RRHAGTDALF
FSGRPGAYGS ISAETTLLVP QILANFTLSV WLKPKPNTDG FVVSKGNGNG TVYYGVQVQT
NDSHVTIMLH YTTIGSNSTH VARATANTFV EDAWVHVIIA VEDGIIEFYL DGSPIPGGIK
SLKGEAIVND ATPIRIGSNP DGEQRFTGLL QDVRLYSSCL NRSQIHELHN QPAKTDLHNV
SGYLTYRQEE KEKSFLVEVR DDQEAEGEEV FYLQLVAVQG GARLPMPRPT AILKVMKSDN
ANGLFSFTGA CIPDIAEEGS MISCVVERTR GALDYVYVNY TVTQLDSPAD LSNASDFANA
TGFILFQPGQ LSEVLNLLVV NDDLPEVDEH FRVRLVSAKS GDGKPGSTPT SGASIDPEKA
VNNVTVKASD HPYGLLQFQT TPVPVGMIRP ALEEARVTVQ EEAGVVRLLV ARAQGLLGRV
MVGYRTSPFT AAGSEDYEGF LDFLPGERFK YINVTIIDNS VPELDKVFRV ELYNPNGGVD
PYFASEGSGS GESETDFFLP SFHYHHANLG AAARIIVTIA ASDEAHGVFQ FGADSLIVNG
TEPEEGRSTV VLQVIRTFGA LSNVTVYWEA DAASEGELVY RSGNVNFEVG QTVRSIYLLI
SQDDVPELDK TFKVRLTNAS HGRLGKETTA TLTVLASDDP YGLFVFSDNT RPVRVAEANA
LVALTIQRRK GLMGRVRVAY RTLRDTDTVL YSTPGVGRAS EGNDFIAVVD SVIFSANQSE
VNVTLRVLDD NEPERAESVF LELVSVTLIE GLQPRPVALS PRLGPRNVTI AQVIIEASDD
AFGVLQLSSS AVSVPEYYTG PIINVTRIGG IFADVSVKFR AVPLTARVGE DYRVASSDVV
LLEGESSKPV PILIINDVVP ELEETFRIEL LNQTTGGALL GDLTQAIITI LPSDDPFGLF
VFQAAPITIE EPALTAFEVS VPIVRNAGTM GDVAVQWRAT VNGRPATGDL RPVSGEVMFS
PGETLKTLKV EVLPDDVPEI EEIIKVELVS ATSGGNIGLE KVVDTIVPAN DNPHGTVYFE
QAVYRVQEPL EGIYIANVTI RRSGGNFGML EVVYSTLEVD IVSNALKEGR NFLVYYDSRL
AGVPSNAIRR PINITTSTNV LNFCAAFCLR ERACQAFSFT NTTTPSCFWV TSGVSQLSPS
PQTFTYLKNT TATASLFSSQ AVAGSDFITM TAQTTTMLDG SGVANLTVPI LTDSLPEMDE
SFIIKILKVS LVNVTATARN LPTIRQPDTA LVTIGMNGDA FGIFLLYSIN PNATQEGLYL
EVREEPKTTV LLVIERRGGS MGQVTVEWKY VGGSATPNAD FNGTGETLIF AEGDVKKTLE
FIITDDTEPE NNETLQIGLV STEGGSRILP SSDTVTILIL ANDNAAGVVG FHTASRSRIV
REGESVTLLV ERTAPAIGNV AVDWRIEGPL VPTTFADTSG TLFFSEGILN NTIVLKLLED
TTPEDREEYR VILSNIQTTG VTKTGIAALS AQGREAVVSV EASDEPFGLL SIAPSSLQVT
TDEKNTTIRI YINREFGASG AVNISYETVR GSLQDLRQTE GALAQPGQDF RYVSNSVIMQ
DGQTSVSIPI TIIDDDIPEL QEFFLVNITS AVLITTLPTA PKLNTEGLVA EIIINANDGI
RGIIGWQNID YVVNETIGVL TLVAYRDAGT YGNVSLFFYA QNLEAQLGLD FNATPSMIYF
VDGERHKFIE VQILDDAVPE GGETFQLILA NPSAGLQLGE NTTATVMILA NDDGHGIISF
NNSEHFLLRE PTSVSGLGTS VATLYIIRDP PQGTFGTVTV QFTITDVNGS LYTDDLTPSS
GFVVLEDGVR YKTLEIWAVL DAEPEMNETF TVTLSNPTGG ARLGVSLQTF ITVLENQAPL
GLFRISPSIN RTLDTMTVEE HMGTVFLTVS RSNGLESAVS VEWETRSGTA FGMRGEQPVL
AVYQSIRDSF ASVWCSVPSG DAALVLRLIK GLTQNQTVLY KWQGVFVPVE FVSIQNPKSC
VGFTVNGSSY VAVSHADNTV SLTTNISLFR VQADLNLTLE QTFSVSGFSV KHFSTDLKQY
LIASSEIFVW NRGSFFLHQS LELQDIIAAV PFRRGSSNVQ HLAVCRNRTS AACFIYQWTD
GRFQNPQPLA LNTEVKQVES HQMGGDTFLF IVTEGLNPAC EVFLWGSQQT VFQQTQSILV
PGLFSVHPFT TPSGIFHLLL AGVNGSALYS WRSELRQFAE MLKSASAQEF LYLPVPSINS
PKSLILASGK SSSLVYELTS VSNQSDFIPS SGELFFQPGV QELEIAVNVI DDDVPEEEEH
FRVSLKNPKG GAEIGFRGQV TFFIPANDDT YGIIGFSQNS LMREVEELQS DNPVSLSIER
RRGRFGRLTV HWSAYGSLDD IFPTSGVVTF SESQAVATIS LNVLADDIPE LAEKVTIVLT
KVTTIGIIDP SRGASIDYQR AQANLTIRAN GSPYGVIGWH LDSQYFITPE PQKSPSNITL
SIVRDQGSSG NVLVYYSTKP ALHLLPLNQA SGGTDYVAKE ATVVMMENAT VVLVFLTILP
DDIPELAETF FVNITRVEVL GGDTGAAQPS VKRPGLEIAE VTIQENDDPR GVLSFNVSKD
VSGAVLAFEV PSPGNVLRLA VMRMAGIFGR LVLYWETQSV TASTEDFTPS SGNITFQDGQ
AMAYIEITII DDTIVESTET FMVKLIRVIG GARLGVETSV VVSIPANDSP FGRFGFEELK
VSVSEPQFLN DPASVATLTV VRSSGGEGVV HLIWLLQEES RDDLSPRNGT LIFNGTESKK
TLVIQALADA VLEGEESFTI QLLSPKNEPV IDPVRGVATV VIRPDVGALG TVGIADSSRN
VLIGEPICSY NGTALISLIR GPGIFGEIEI FWNITTAAVS EFEETSGKVV MKDRQSAATI
QLKALDDEIP EERRVYQLRL SSLTPGSVIN PDRQFASITM AASDLPHGLF SFSQASLRAT
EEDRAVNVTI VRSMGLFGSV WVSFHTEGRT AISGQDFGQS SGRPLFRPGE SSRVIPLVIF
DDDLPEGPEE FFLNITLVEL LNASSMDFTV REYGLQIDQP PAIGNLSSLM VIIQKNDNAE
GILEFDPKYV NNTVEEDVGT LSIPVLRRVG SYGQVTVQFV SKGLTAQPDS DYILLNGSIT
FQHGQTLSYI NVSIVDDTES EFNEIFELQL TGATGGAILG AQLIARITIA KSDSPNGVVR
FINQSAITIP NPNSTVRLSL FAERADGLLG DATVMWHIQG PNSNEVLPSM NTDIEPVNGT
FSFRDGEGGV RSIDLKILPH GEVEVTEKFI IMLSVISGEM GVDPRAGSVT LTIEKFGDPN
GIVQFTEQDL KERIYSEPSD SEGPLKVSVL VTRREGVMGN ITVFWEILSD ADTSGDFAAL
RGSVIILAGQ RLAEIILTLL PDSVPELEET YTLRLTSVEG GAELDLNRSS TRLKVRANDE
PHGVFVMYSQ NQSVVVNAAD RSRQLIISVN RLAGAFGNAS VGYRISFTTP GQSFTEDTIT
GNILVKDGER EASIRVPVSS QVFFVTGFNF SVELTDVTLI GPLLGSPPRI QLESKLAVVS
VPEVAANPVV GFASLALRVL DIESGQCEAL VTRTGLYGNI TVRWSSGFPP GQTPPGYQPG
EILPRSGSIM LAHGQRSELI SFTALNNISV VTAHAIYLTS VESESPGGAR LRTGYTVAEV
EPLGLYQFHP NSQHLVIEED VQTITLYVQR FYGFRSNRSS VSYRTWPGTA QPDKDYVPVT
DGQLLFDSRQ TSASIRLSIL DDTLTEPDED FYVNLTSVRV LSTTLPLITA QPGIVQKNSI
STVTIRANDV VSGFLSIGPA VKLISEDSVE DSPQQKLQLR VRRTAGLSGV VSAKIRAYAG
LKTPLVDASQ FHREHKGTWA LEGEDFALET QSVTLLEGQN EVEVTVIMLN DQEPEGQEAF
FIYLSDAEGG AQIVSVPDEL GFTSFAKIII LGSDLQNGIV GFSLSSLSGQ VLDEDSVNRT
VTLVLQRQEN RAFEDVLVFW RVTFSTTDHA LVSHGVDLSK ELLQTSGTSI RRKGEVLCAL
KLEVQPDKNP EYEVWFLVEV YKVGEGAAIN QTARFANITM LESDDPRGLV YFAQGSRLPV
VTLKATSVSL QIYRDASTAS SISVEYRMQE LPKVESIGPS LVWPAVAGQD FVMSEGTLTF
EIGQSSAGLN IDLTPNIGSS NLTPKRFQVV LSDATGGARV HPEFGLANVT LVSDTETQAV
WALLDQLHQP LEETIINRVL HALINKVSRD ITPEQLMAVL DASSKILSDA EQTPLKDSSR
GLTYDLLCAM ANPNRTDTQG VSQLSEVAER FAYSLLTDIK CGAEGKRGIT ILDNCPYFTI
AAHHWYPMQI NGHTFIGKNT DTFTLPETLL EVPALPADST APSACYKVHF TEYSTEHWFL
TNKKPSALNG KVFSVSLYGR GSKPLSEGQE VVYRIHTPDR RGKPKPSQSL CLLWNQAAES
WLSDGQFCRL VDDTQNYVEC ACSHLSIYTA YAEIESLASF NEAFYAAGFI CISGFALAMV
SHLMCARFLM FAAKLLTHMM VACLGTQICF LVSAFRGRMF SEDSCAALGL FFHYFHLSQF
GWMLVQAINF WQILVMNDEH TERRYLLYFL LSWGLPALVI IVLVVVLLGG FGWSIHSVYG
LVQGDLCFIP NVYAALCTAA LVPLICLVGV LVIFIHAYQV TQQWKAYDDI YRGRTNSSEV
PMMLYLFALV TLVCVWAGLH MAYRYIWMLI LLVIFNIFLG LYVFSVYFVM HNQLFWPGKA
TYTVEMNGHS SPDSIYQSTG AATVGGGEIS KSTQNLISAM EEISADWERA SLRPSSQPSS
IFKPSPQDEA YITEGGFINT SLVRDEESQE FDDLIFALKT GSGLNVSDNE SIHGSHDGGS
MANSQIVELR RIPIADTHL
