ID   ETT1_KLULA              Reviewed;         427 AA.
AC   Q6CJT2;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Enhancer of translation termination 1;
GN   Name=ETT1; OrderedLocusNames=KLLA0F16148g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for correct translation termination and probably
CC       involved in regulation of hypoxic gene expression. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ETT1 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98515.1; -; Genomic_DNA.
DR   RefSeq; XP_455807.1; XM_455807.1.
DR   AlphaFoldDB; Q6CJT2; -.
DR   STRING; 28985.XP_455807.1; -.
DR   PRIDE; Q6CJT2; -.
DR   EnsemblFungi; CAG98515; CAG98515; KLLA0_F16148g.
DR   GeneID; 2895677; -.
DR   KEGG; kla:KLLA0_F16148g; -.
DR   eggNOG; ENOG502QPHX; Eukaryota.
DR   HOGENOM; CLU_050427_0_0_1; -.
DR   InParanoid; Q6CJT2; -.
DR   OMA; GIVHECD; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   GO; GO:0006415; P:translational termination; IEA:EnsemblFungi.
DR   InterPro; IPR024318; Nro1/ETT1.
DR   PANTHER; PTHR28290; PTHR28290; 1.
DR   Pfam; PF12753; Nro1; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation;
KW   Translation regulation.
FT   CHAIN           1..427
FT                   /note="Enhancer of translation termination 1"
FT                   /id="PRO_0000406617"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   427 AA;  49044 MW;  6543C516DA76567C CRC64;
     MAKRALGLGK SKKQKKQKVA VPEEQSSEGT VPAPSAANQI EIALDENEDA DDELVQLKGL
     WETFLKDKDN QLLLNGVVHE CDRLLRLQDN DSTIKLSDLF HSIYAQALAE LTVFLPEETD
     DEEKKYERMN EFFDAALERY RLGAEKYPET PLLSLTQTKI ILQRIPLQYI SQLSPLDQND
     EKYKLYDLLE SAKSSYTLSS NQHQLAYDVL LSFYDLLDII ETFEDKEELE DGLDSDDEGE
     ELVEVVLHEN HPLTKIKKNM NQNYEWLKEN LLNLFNDISS SFCNKVGPDI DKDHPTVVLF
     KSIARTLGQL YLKLAEEPSK TFAELMYDSD DEEQTDKEAL EKAKNAQSKA IPLVEYAIRY
     LQEAKVEDEP QTWVDVAEAI IDLGNLYDYE SKEQEDSYKR AEEILLKANK ATHGKYQVIL
     DNLLNKD