ID   ETT1_KOMPG              Reviewed;         438 AA.
AC   C4QV62;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Enhancer of translation termination 1;
GN   Name=ETT1; OrderedLocusNames=PAS_chr1-3_0079;
OS   Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=644223;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS115 / ATCC 20864;
RX   PubMed=19465926; DOI=10.1038/nbt.1544;
RA   De Schutter K., Lin Y.-C., Tiels P., Van Hecke A., Glinka S.,
RA   Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT   "Genome sequence of the recombinant protein production host Pichia
RT   pastoris.";
RL   Nat. Biotechnol. 27:561-566(2009).
CC   -!- FUNCTION: Required for correct translation termination and probably
CC       involved in regulation of hypoxic gene expression. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ETT1 family. {ECO:0000305}.
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DR   EMBL; FN392319; CAY67135.1; -; Genomic_DNA.
DR   RefSeq; XP_002489416.1; XM_002489371.1.
DR   AlphaFoldDB; C4QV62; -.
DR   SMR; C4QV62; -.
DR   STRING; 644223.C4QV62; -.
DR   EnsemblFungi; CAY67135; CAY67135; PAS_chr1-3_0079.
DR   GeneID; 8197389; -.
DR   KEGG; ppa:PAS_chr1-3_0079; -.
DR   eggNOG; ENOG502QPHX; Eukaryota.
DR   HOGENOM; CLU_050427_0_0_1; -.
DR   InParanoid; C4QV62; -.
DR   OMA; GIVHECD; -.
DR   Proteomes; UP000000314; Chromosome 1.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   InterPro; IPR024318; Nro1/ETT1.
DR   PANTHER; PTHR28290; PTHR28290; 1.
DR   Pfam; PF12753; Nro1; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation;
KW   Translation regulation.
FT   CHAIN           1..438
FT                   /note="Enhancer of translation termination 1"
FT                   /id="PRO_0000406621"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          230..262
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        236..251
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   438 AA;  49667 MW;  B4DB29E77490EC30 CRC64;
     MAPPKRPLGL GKSAQKKKQK TDEDGVAESG SSANASELTV ELNEEVDADD EVSQLFALWK
     TFLGAEKDNE LVLNGIIHEC DRLLRNSQTE KNKYKLNGEF HAIYALALNE LAFFHAAKEN
     DVKPYFDEAL ERIDLGLSHS KEDPRLLFSK AHIIFNRVPL EYISKMTPES SSEGYPNILE
     VLDDALKSYE AAQNEAIKTE RFELFDQETF RVLDSLDDLL SIIDDFGKKK SSDEGIDSED
     EEELGFDEDE DSLQLSESHP LKPLGESEKY DIWWRTQTIE FLKNLEKLAQ KSDIILKDSS
     LPIGNLHRDV CKKLGQSYLL EAEEPSAIFT TLEYDSDVED KEDGINGLQA DQARDIAIQL
     VTEAIQYLEK AEYSDDPKSW ADVAEAYVTL GNLHSVDSRE QEDCYSKAEK RLQHANKATH
     GKYEHILNNL LQKSYDDT