ID   ETT1_LACTC              Reviewed;         423 AA.
AC   C5DJK6;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Enhancer of translation termination 1;
GN   Name=ETT1; OrderedLocusNames=KLTH0F17204g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Required for correct translation termination and probably
CC       involved in regulation of hypoxic gene expression. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ETT1 family. {ECO:0000305}.
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DR   EMBL; CU928170; CAR24495.1; -; Genomic_DNA.
DR   RefSeq; XP_002554932.1; XM_002554886.1.
DR   AlphaFoldDB; C5DJK6; -.
DR   SMR; C5DJK6; -.
DR   STRING; 559295.C5DJK6; -.
DR   PRIDE; C5DJK6; -.
DR   EnsemblFungi; CAR24495; CAR24495; KLTH0F17204g.
DR   GeneID; 8293166; -.
DR   KEGG; lth:KLTH0F17204g; -.
DR   eggNOG; ENOG502QPHX; Eukaryota.
DR   HOGENOM; CLU_050427_0_0_1; -.
DR   InParanoid; C5DJK6; -.
DR   OMA; GIVHECD; -.
DR   OrthoDB; 1255094at2759; -.
DR   Proteomes; UP000002036; Chromosome F.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR024318; Nro1/ETT1.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR28290; PTHR28290; 1.
DR   Pfam; PF12753; Nro1; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation;
KW   Translation regulation.
FT   CHAIN           1..423
FT                   /note="Enhancer of translation termination 1"
FT                   /id="PRO_0000406618"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   423 AA;  47951 MW;  999147E2EFB3E2C0 CRC64;
     MAKRALGIGK QNKTAKKQKK SDSPTPEPTP ASQIQVEIEE GVDPDDELVQ LRGLWKTYFN
     SDRDDELVLN GIVHECDRLL REKENTEQAK DKEKPHTELS DEFHAIYALA LSELTIFRAG
     DESMDEKDCR KAVAQFFDAA LERCDIGLSQ FPDSGLLKLT HAKIVLQRIP LQYISKLTSE
     SKNAKKLKLH EQLEQAKRDL VLDFKYRDLV FDVLQLLDDL LDICENWGQG ADDDEEPLGS
     DTEEQVRDLE LPAEHPLSQI RAETPENFSF LREKLKELLA TLPKPDTKDV DSKDVELYRS
     VARKLGQLHL RAAEPASQAF LLLTYESTGE KEMHGFSAPQ AQAEALSLVR AAVKYLEEAR
     EDDEPQTWVD IAEALTSLGN LYDAESKEQE ECYKKAEDIL KKANKATHGK YQDVLDNLLE
     AKD