ID   ETT1_LODEL              Reviewed;         488 AA.
AC   A5DTP3;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Enhancer of translation termination 1;
GN   Name=ETT1; ORFNames=LELG_00729;
OS   Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS   1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC   Lodderomyces.
OX   NCBI_TaxID=379508;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC   YB-4239;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Required for correct translation termination and probably
CC       involved in regulation of hypoxic gene expression. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ETT1 family. {ECO:0000305}.
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DR   EMBL; CH981524; EDK42551.1; -; Genomic_DNA.
DR   RefSeq; XP_001528209.1; XM_001528159.1.
DR   AlphaFoldDB; A5DTP3; -.
DR   STRING; 379508.A5DTP3; -.
DR   EnsemblFungi; EDK42551; EDK42551; LELG_00729.
DR   GeneID; 5235883; -.
DR   KEGG; lel:LELG_00729; -.
DR   VEuPathDB; FungiDB:LELG_00729; -.
DR   eggNOG; ENOG502QPHX; Eukaryota.
DR   HOGENOM; CLU_050427_0_0_1; -.
DR   InParanoid; A5DTP3; -.
DR   OMA; GIVHECD; -.
DR   OrthoDB; 1255094at2759; -.
DR   Proteomes; UP000001996; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   InterPro; IPR024318; Nro1/ETT1.
DR   PANTHER; PTHR28290; PTHR28290; 1.
DR   Pfam; PF12753; Nro1; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation;
KW   Translation regulation.
FT   CHAIN           1..488
FT                   /note="Enhancer of translation termination 1"
FT                   /id="PRO_0000406619"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          242..272
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          287..328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..38
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        242..259
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        295..323
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   488 AA;  55631 MW;  693721A69B0EC5BD CRC64;
     MAKRTLGLGN AARAKKQKLE QEGKSKSPTP SGSEDTTNQL TIELPETVDA NDEIAQLRGL
     YKTYIDSERD SDLILNGIIH ECDRLLREKV ANSSGSKENQ VSAELPAMFY KIYAIALSEL
     ANFHTDDIDQ VSEFFDASLE RVNDGLEKYP TDIDLVFTKA KILINQIVLQ YVSQLKLESS
     VEEAHIKNMD IKGKLDAALR VYESAEKKAK ESEDYLAFNS EEYWDILEAV DDLLDIVDNF
     GRQEEEEEEE EEEEEEEEEK EDHAKKGGEL TELDVADAEA FAAAQEKIEG EEKGSETSDN
     DEEDNEEEEE EEEDEDEEEE IELPETHPLY IIKTTDEYNQ WWRDHTLTYL SNLKQLSNAS
     PRLLREVNHR LGQSYLQEAE VPSSVFTTLR YDEDYSGIEE LEGLSEDDAK RVAQELIIKA
     LEYLKAAEDK DEPESWVNIA EAMISLANLY EVESKEQEQL YQDAEKILTK ANNATNGKYQ
     DALDNLLG