ID   ETT1_PICGU              Reviewed;         418 AA.
AC   A5DQI5;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Enhancer of translation termination 1;
GN   Name=ETT1; ORFNames=PGUG_05536;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Required for correct translation termination and probably
CC       involved in regulation of hypoxic gene expression. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ETT1 family. {ECO:0000305}.
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DR   EMBL; CH408161; EDK41438.2; -; Genomic_DNA.
DR   RefSeq; XP_001482516.1; XM_001482466.1.
DR   AlphaFoldDB; A5DQI5; -.
DR   SMR; A5DQI5; -.
DR   STRING; 4929.XP_001482516.1; -.
DR   PRIDE; A5DQI5; -.
DR   EnsemblFungi; EDK41438; EDK41438; PGUG_05536.
DR   GeneID; 5124180; -.
DR   KEGG; pgu:PGUG_05536; -.
DR   VEuPathDB; FungiDB:PGUG_05536; -.
DR   eggNOG; ENOG502QPHX; Eukaryota.
DR   HOGENOM; CLU_050427_0_0_1; -.
DR   InParanoid; A5DQI5; -.
DR   OMA; GIVHECD; -.
DR   OrthoDB; 1255094at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR024318; Nro1/ETT1.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR28290; PTHR28290; 1.
DR   Pfam; PF12753; Nro1; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation;
KW   Translation regulation.
FT   CHAIN           1..418
FT                   /note="Enhancer of translation termination 1"
FT                   /id="PRO_0000406620"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          222..241
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..35
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   418 AA;  48168 MW;  751D6DD22A8C6161 CRC64;
     MAKRQLGLGK AAKAKKQKTE TSQSTAATSQ KPNETLRVEL NEEADADDEL AQLQALWNTY
     SKSDKENELM VNGIIHECDR LLRNWDEKNE ALPDYFHAIY ALALSELAKY KPEETSQCFQ
     MALERLDAGL AAYPKSIDVN FAKSRVLLAR IPLQYISTLE VSSQVGDYPN VSEMLDEALS
     VYEVAETEAE ARKEYSKFNE DNLDILQALD DVLDMMDNFC KKEEEEDEEK EDDDDEEEDE
     EEEVIQLAEN HPLYHIQATD KYNFWWRNHT LKFLTNVTKR TENTTQLQRE LCTRLGQSYL
     QEAEVPANVY TTLKYDDDYA GLGELQGLQM EEGQKLAQES FKEALKYLKK AQDDDDPDTW
     VNVAEAMISL GNMYEMDSPD QEKWYDEAEK ILVRANKATQ GKYREILENL RGEDEGDE