ID   ETT1_VANPO              Reviewed;         408 AA.
AC   A7TQ03;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Enhancer of translation termination 1;
GN   Name=ETT1; ORFNames=Kpol_473p11;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Required for correct translation termination and probably
CC       involved in regulation of hypoxic gene expression. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ETT1 family. {ECO:0000305}.
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DR   EMBL; DS480450; EDO15652.1; -; Genomic_DNA.
DR   RefSeq; XP_001643510.1; XM_001643460.1.
DR   AlphaFoldDB; A7TQ03; -.
DR   SMR; A7TQ03; -.
DR   STRING; 436907.A7TQ03; -.
DR   PRIDE; A7TQ03; -.
DR   EnsemblFungi; EDO15652; EDO15652; Kpol_473p11.
DR   GeneID; 5543743; -.
DR   KEGG; vpo:Kpol_473p11; -.
DR   eggNOG; ENOG502QPHX; Eukaryota.
DR   HOGENOM; CLU_050427_0_0_1; -.
DR   InParanoid; A7TQ03; -.
DR   OMA; GIVHECD; -.
DR   OrthoDB; 1255094at2759; -.
DR   PhylomeDB; A7TQ03; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   InterPro; IPR024318; Nro1/ETT1.
DR   PANTHER; PTHR28290; PTHR28290; 1.
DR   Pfam; PF12753; Nro1; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation;
KW   Translation regulation.
FT   CHAIN           1..408
FT                   /note="Enhancer of translation termination 1"
FT                   /id="PRO_0000406623"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          311..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..23
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   408 AA;  46780 MW;  74B0AE8CB91E4F55 CRC64;
     MAKRALGLGQ KNREKKRKVE SGSEGGSRNA TPTVTNQIQI ELGEGVDPDN ELAQLHGLWL
     NYFKSERDDE YMLNGIVHEC DRLIRQAQED EEMAKQLNDR FHAIYALALS ELTIFKAAEE
     EGKERKLVSE FFGNALDRLS YGQAAHPDSN LLKLVFAKIL LQRIPLEYIF KLEVDSEEKL
     DLHQKLEDAK KNFVIVDSDL ELSYEVLNML NDLLDIVENF GHEDDIEEGL DSDDEDGIDL
     VELKTTHPLY QIQQQVPENY QWLRSSFDNL LESIKEKDSE LFRSVARSIG ELLLKEAEEP
     ASTYLSIIYG NEDDDEDVEP TDESKEAQKK AQELTKKALE YLEKAQNEED PKTWVQVAEA
     QIDLGNLLDY QSSEQESAYK KAEDILRKAN KATKGKFQFI LDNLLEKE