ID   ETT1_YARLI              Reviewed;         377 AA.
AC   Q6C872;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Enhancer of translation termination 1;
GN   Name=ETT1; OrderedLocusNames=YALI0D22132g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for correct translation termination and probably
CC       involved in regulation of hypoxic gene expression. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ETT1 family. {ECO:0000305}.
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DR   EMBL; CR382130; CAG81338.1; -; Genomic_DNA.
DR   RefSeq; XP_503140.1; XM_503140.1.
DR   AlphaFoldDB; Q6C872; -.
DR   SMR; Q6C872; -.
DR   STRING; 4952.CAG81338; -.
DR   EnsemblFungi; CAG81338; CAG81338; YALI0_D22132g.
DR   GeneID; 2911046; -.
DR   KEGG; yli:YALI0D22132g; -.
DR   VEuPathDB; FungiDB:YALI0_D22132g; -.
DR   HOGENOM; CLU_050427_0_0_1; -.
DR   InParanoid; Q6C872; -.
DR   Proteomes; UP000001300; Chromosome D.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:2000640; P:positive regulation of SREBP signaling pathway; IBA:GO_Central.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   GO; GO:0006415; P:translational termination; IBA:GO_Central.
DR   InterPro; IPR024318; Nro1/ETT1.
DR   PANTHER; PTHR28290; PTHR28290; 1.
DR   Pfam; PF12753; Nro1; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation;
KW   Translation regulation.
FT   CHAIN           1..377
FT                   /note="Enhancer of translation termination 1"
FT                   /id="PRO_0000406624"
FT   REGION          1..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..38
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   377 AA;  42174 MW;  0B195C30D6CEEF82 CRC64;
     MAKRPLGLNK ANKSKKKKLD SAEKAEKAVA KEISPENDES AEPAPALTLD ADEEDDMGQL
     ESLYKNWTSS ERDSPRILHG VVHECDSLLQ KAKGEGLPAR FHEIYAASLL DLAEFADKKK
     PVKKKKVKSD DVAPETSDMF VDAALERVET GLEQYPEDAG LLFVKSRALK QDIDEKMSAV
     SKEERKETAK KMISQLNKIL EVFKLAQKHA STVTPAQLDV VEELIELSGA LESVVKQSDI
     SETTLVACEK FYNEILASEK DENTVKKAHR GVGTCKMIVA DSLLDLLDDD DEDNDDTVEL
     AKKNLKAAIE HFQKSETDED GEFMVTLAET MIQYGNLFET ESDDQKKWYG EAVKRLRQAQ
     RLGVGKYDEM ILELEDD