ETT1_YEAS8
ID ETT1_YEAS8 Reviewed; 412 AA.
AC C8ZI12;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 03-NOV-2009, sequence version 1.
DT 25-MAY-2022, entry version 38.
DE RecName: Full=Enhancer of translation termination 1;
GN Name=ETT1; ORFNames=EC1118_1O4_2498g;
OS Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) (Baker's
OS yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=643680;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lalvin EC1118 / Prise de mousse;
RX PubMed=19805302; DOI=10.1073/pnas.0904673106;
RA Novo M., Bigey F., Beyne E., Galeote V., Gavory F., Mallet S., Cambon B.,
RA Legras J.-L., Wincker P., Casaregola S., Dequin S.;
RT "Eukaryote-to-eukaryote gene transfer events revealed by the genome
RT sequence of the wine yeast Saccharomyces cerevisiae EC1118.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:16333-16338(2009).
CC -!- FUNCTION: Required for correct translation termination and probably
CC involved in regulation of hypoxic gene expression in association TPA1.
CC Inhibits replication of Brome mosaic virus (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with STM1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ETT1 family. {ECO:0000305}.
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DR EMBL; FN394216; CAY86337.1; -; Genomic_DNA.
DR AlphaFoldDB; C8ZI12; -.
DR SMR; C8ZI12; -.
DR EnsemblFungi; CAY86337; CAY86337; EC1118_1O4_2498g.
DR HOGENOM; CLU_050427_0_0_1; -.
DR Proteomes; UP000000286; Chromosome XV, Scaffold EC1118_1O4.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR024318; Nro1/ETT1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR28290; PTHR28290; 1.
DR Pfam; PF12753; Nro1; 1.
PE 3: Inferred from homology;
KW Nucleus; Phosphoprotein; Transcription; Transcription regulation;
KW Translation regulation.
FT CHAIN 1..412
FT /note="Enhancer of translation termination 1"
FT /id="PRO_0000406629"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..32
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 30
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q08421"
SQ SEQUENCE 412 AA; 47468 MW; 2988026AE800F282 CRC64;
MAKRPLGLGK QSREKKRKVE SVEKKSDEPS RESTPVRSQM SVELDDDADL DDELAQLKGL
WSKYFHSDRD DEYVLNGIVH ECDRLLRLSE EDKEIKKTLN DIFHGIYALA LSELTIFKAG
DEEATEEKRK KDVSSFFENA IERVELGLSH FPESQFLKLV LAKIIFQRIP LEYISNLHLK
SKDKKLDLVG QLEHGKKHFS IYENDTEFTF EILQMVNDLL DIVENFGREQ SIQEGIDSDN
EEEEELIDIE LEPEHPVYPL QQSLEANYEW LRNHFDKLLD NTNTDMKIYA SIANTLGELY
LKKAEEPSKV FLSLQYDDGS SKKVSDKEAK NVQETALKHT KKALEYLEKA KLEDDPDTWV
QVAEAYIDLG NLLDNESAEQ EEAYKTAEEI LGKANKASHG KFQDVLDNFL QG