ID   ETV1_BOVIN              Reviewed;         477 AA.
AC   Q2KIC2;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=ETS translocation variant 1 {ECO:0000305};
GN   Name=ETV1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional activator that binds to DNA sequences
CC       containing the consensus pentanucleotide 5'-CGGA[AT]-3' (By
CC       similarity). Required for olfactory dopaminergic neuron
CC       differentiation; may directly activate expression of tyrosine
CC       hydroxylase (TH) (By similarity). {ECO:0000250|UniProtKB:P41164,
CC       ECO:0000250|UniProtKB:P50549}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
CC   -!- PTM: Sumoylated. {ECO:0000250|UniProtKB:P50549}.
CC   -!- PTM: Phosphorylated at Ser-191 and Ser-216 by RPS6KA1 and RPS6KA5;
CC       phosphorylation activates transcriptional activity.
CC       {ECO:0000250|UniProtKB:P50549}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR   EMBL; BC112692; AAI12693.1; -; mRNA.
DR   RefSeq; NP_001039957.1; NM_001046492.2.
DR   RefSeq; XP_005205260.1; XM_005205203.3.
DR   AlphaFoldDB; Q2KIC2; -.
DR   SMR; Q2KIC2; -.
DR   STRING; 9913.ENSBTAP00000021259; -.
DR   PaxDb; Q2KIC2; -.
DR   PRIDE; Q2KIC2; -.
DR   Ensembl; ENSBTAT00000021259; ENSBTAP00000021259; ENSBTAG00000015981.
DR   Ensembl; ENSBTAT00000075156; ENSBTAP00000064027; ENSBTAG00000015981.
DR   GeneID; 540846; -.
DR   KEGG; bta:540846; -.
DR   CTD; 2115; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015981; -.
DR   VGNC; VGNC:28628; ETV1.
DR   eggNOG; KOG3806; Eukaryota.
DR   GeneTree; ENSGT00940000157123; -.
DR   HOGENOM; CLU_030025_1_0_1; -.
DR   InParanoid; Q2KIC2; -.
DR   OMA; DYQAESX; -.
DR   OrthoDB; 536648at2759; -.
DR   TreeFam; TF316214; -.
DR   Proteomes; UP000009136; Chromosome 4.
DR   Bgee; ENSBTAG00000015981; Expressed in saliva-secreting gland and 97 other tissues.
DR   ExpressionAtlas; Q2KIC2; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0048935; P:peripheral nervous system neuron development; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR046328; ETS_fam.
DR   InterPro; IPR006715; ETS_PEA3_N.
DR   InterPro; IPR032928; ETS_V1.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849; PTHR11849; 1.
DR   PANTHER; PTHR11849:SF196; PTHR11849:SF196; 1.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF04621; ETS_PEA3_N; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation;
KW   Ubl conjugation.
FT   CHAIN           1..477
FT                   /note="ETS translocation variant 1"
FT                   /id="PRO_0000287133"
FT   DNA_BIND        335..415
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT   REGION          128..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        145..159
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         94
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P43268"
FT   MOD_RES         191
FT                   /note="Phosphoserine; by RPS6KA1 and RPS6KA5"
FT                   /evidence="ECO:0000250|UniProtKB:P50549"
FT   MOD_RES         216
FT                   /note="Phosphoserine; by RPS6KA1 and RPS6KA5"
FT                   /evidence="ECO:0000250|UniProtKB:P50549"
FT   CROSSLNK        317
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:P50549"
SQ   SEQUENCE   477 AA;  55129 MW;  5F3AD6E355E266A8 CRC64;
     MDGFYDQQVP YMVTNNQRGR NCNEKPTNVR KRKFINRDLA HDSEELFQDL SQLQETWLAE
     AQVPDNDEQF VPDYQAESLA FHGLPLKIKK EPHSPCSELG SACSQEQPFK FSYGEKCLYN
     VSAYDQKPQV GMRPSNPPTP SSTPVSPLHH ASPNSAHTSK PDRAFPAHLP PSQPIQDSSY
     PMDHRFRRQL SEPCNSFPPL PTMPREGRPM YQRQMSEPNI PFPPQGFKQE YHDPVYEHNT
     MVGGAASQSF PPPLMIKQEP RDFAYDSEVP SCHSIYMRQE GFLTHPSRTE GCMFEKGPRQ
     FYDDTCVVPE KFDGDIKQEP GMYREGPTYQ RRGSLQLWQF LVALLDDPSN SHFIAWTGRG
     MEFKLIEPEE VARRWGIQKN RPAMNYDKLS RSLRYYYEKG IMQKVAGERY VYKFVCDPEA
     LFSMAFPDNQ RPLLKTDMER HINEEDTVPL SHFDESMAYM PEGGCCNPHP YNEGYVY