ETV1_MOUSE
ID ETV1_MOUSE Reviewed; 477 AA.
AC P41164;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=ETS translocation variant 1 {ECO:0000305};
DE AltName: Full=Ets-related protein 81 {ECO:0000312|MGI:MGI:99254};
GN Name=Etv1 {ECO:0000312|MGI:MGI:99254};
GN Synonyms=Er81 {ECO:0000303|PubMed:1340465},
GN Etsrp81 {ECO:0000312|MGI:MGI:99254};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|Proteomes:UP000000589};
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Embryo;
RX PubMed=1340465; DOI=10.1101/gad.6.12b.2502;
RA Brown T.A., McKnight S.L.;
RT "Specificities of protein-protein and protein-DNA interaction of GABP alpha
RT and two newly defined ets-related proteins.";
RL Genes Dev. 6:2502-2512(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NMRI; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=19287374; DOI=10.1038/nature07929;
RA Flames N., Hobert O.;
RT "Gene regulatory logic of dopamine neuron differentiation.";
RL Nature 458:885-889(2009).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Transcriptional activator that binds to DNA sequences
CC containing the consensus pentanucleotide 5'-CGGA[AT]-3'
CC (PubMed:1340465). Required for olfactory dopaminergic neuron
CC differentiation; may directly activate expression of tyrosine
CC hydroxylase (TH) (PubMed:19287374). {ECO:0000269|PubMed:1340465,
CC ECO:0000269|PubMed:19287374}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
CC -!- TISSUE SPECIFICITY: Abundant in kidney (PubMed:1340465). Moderate
CC levels seen in the heart, brain, lung, embryo and lower levels seen in
CC spleen, intestine, testis and thymus (PubMed:1340465).
CC {ECO:0000269|PubMed:1340465}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the dopaminergic neurons of the
CC olfactory bulb at postnatal day 0 (at protein level).
CC {ECO:0000269|PubMed:19287374}.
CC -!- PTM: Sumoylated. {ECO:0000250|UniProtKB:P50549}.
CC -!- PTM: Phosphorylated at Ser-191 and Ser-216 by RPS6KA1 and RPS6KA5;
CC phosphorylation activates transcriptional activity.
CC {ECO:0000250|UniProtKB:P50549}.
CC -!- DISRUPTION PHENOTYPE: Significant reduction in the number of tyrosine
CC hydroxylase (TH)-positive cells in the olfactory bulb.
CC {ECO:0000269|PubMed:19287374}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR EMBL; L10426; AAA20075.1; -; mRNA.
DR EMBL; BC005645; AAH05645.1; -; mRNA.
DR CCDS; CCDS49053.1; -.
DR PIR; B46396; B46396.
DR RefSeq; NP_031986.1; NM_007960.5.
DR RefSeq; XP_006515028.1; XM_006514965.2.
DR AlphaFoldDB; P41164; -.
DR SMR; P41164; -.
DR BioGRID; 199539; 1.
DR DIP; DIP-60465N; -.
DR IntAct; P41164; 1.
DR STRING; 10090.ENSMUSP00000093442; -.
DR iPTMnet; P41164; -.
DR PhosphoSitePlus; P41164; -.
DR PaxDb; P41164; -.
DR PRIDE; P41164; -.
DR ProteomicsDB; 267662; -.
DR Antibodypedia; 25156; 326 antibodies from 33 providers.
DR DNASU; 14009; -.
DR Ensembl; ENSMUST00000095767; ENSMUSP00000093442; ENSMUSG00000004151.
DR Ensembl; ENSMUST00000162563; ENSMUSP00000125157; ENSMUSG00000004151.
DR GeneID; 14009; -.
DR KEGG; mmu:14009; -.
DR UCSC; uc033gdb.1; mouse.
DR CTD; 2115; -.
DR MGI; MGI:99254; Etv1.
DR VEuPathDB; HostDB:ENSMUSG00000004151; -.
DR eggNOG; KOG3806; Eukaryota.
DR GeneTree; ENSGT00940000157123; -.
DR HOGENOM; CLU_030025_1_0_1; -.
DR InParanoid; P41164; -.
DR OMA; DYQAESX; -.
DR OrthoDB; 536648at2759; -.
DR PhylomeDB; P41164; -.
DR TreeFam; TF316214; -.
DR BioGRID-ORCS; 14009; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Etv1; mouse.
DR PRO; PR:P41164; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; P41164; protein.
DR Bgee; ENSMUSG00000004151; Expressed in parotid gland and 257 other tissues.
DR ExpressionAtlas; P41164; baseline and differential.
DR Genevisible; P41164; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0007411; P:axon guidance; IMP:MGI.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0007638; P:mechanosensory behavior; IMP:MGI.
DR GO; GO:0007517; P:muscle organ development; IMP:MGI.
DR GO; GO:0048935; P:peripheral nervous system neuron development; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR006715; ETS_PEA3_N.
DR InterPro; IPR032928; ETS_V1.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; PTHR11849; 1.
DR PANTHER; PTHR11849:SF196; PTHR11849:SF196; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF04621; ETS_PEA3_N; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation;
KW Ubl conjugation.
FT CHAIN 1..477
FT /note="ETS translocation variant 1"
FT /id="PRO_0000204111"
FT DNA_BIND 335..415
FT /note="ETS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT REGION 128..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 94
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P43268"
FT MOD_RES 191
FT /note="Phosphoserine; by RPS6KA1 and RPS6KA5"
FT /evidence="ECO:0000250|UniProtKB:P50549"
FT MOD_RES 216
FT /note="Phosphoserine; by RPS6KA1 and RPS6KA5"
FT /evidence="ECO:0000250|UniProtKB:P50549"
FT CROSSLNK 317
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P50549"
SQ SEQUENCE 477 AA; 55041 MW; AA211595324CF7B8 CRC64;
MDGFYDQQVP YVVTNSQRGR NCTEKPTNVR KRKFINRDLA HDSEELFQDL SQLQETWLAE
AQVPDNDEQF VPDYQAESLA FHGLPLKIKK EPHSPCSELG SACSQEQPFK FSYGEKCLYN
VSAYDQKPQV GMRPSNPPTP SSTPVSPLHH ASPNTAHTPK PDRAFPAHLP PSQSIPDSTY
PMDHRFRRQL SEPCNSFPPL PTMPREGRPM YQRQMSEPNI PFPPQGFKQE YHDPVYEHTT
MVGGAASQSF PPPLMIKQEP RDFAYDSEVP SCHSIYMRQE GFLAHPSRTE GCMFEKGPRQ
FYDDTCVVPE KFDGDIKQEP GMYREGPTYQ RRGSLQLWQF LVALLDDPSN SHFIAWTGRG
MEFKLIEPEE VARRWGIQKN RPAMNYDKLS RSLRYYYEKG IMQKVAGERY VYKFVCDPEA
LFSMAFPDNQ RPLLKTDMER HINEEDTVPL SHFDESMTYM PEGGCCNPHP YNEGYVY
