ETV2_MOUSE
ID ETV2_MOUSE Reviewed; 335 AA.
AC P41163; F8VQ08;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=ETS translocation variant 2;
DE AltName: Full=Ets-related protein 71;
GN Name=Etv2; Synonyms=Er71, Etsrp71;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Embryo;
RX PubMed=1340465; DOI=10.1101/gad.6.12b.2502;
RA Brown T.A., McKnight S.L.;
RT "Specificities of protein-protein and protein-DNA interaction of GABP alpha
RT and two newly defined ets-related proteins.";
RL Genes Dev. 6:2502-2512(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Binds to DNA sequences containing the consensus
CC pentanucleotide 5'-CGGA[AT]-3'.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Testis.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR EMBL; L10427; AAA19665.1; -; mRNA.
DR EMBL; AC167978; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS39888.1; -.
DR RefSeq; NP_031985.2; NM_007959.2.
DR AlphaFoldDB; P41163; -.
DR SMR; P41163; -.
DR STRING; 10090.ENSMUSP00000103782; -.
DR PhosphoSitePlus; P41163; -.
DR PaxDb; P41163; -.
DR PRIDE; P41163; -.
DR Antibodypedia; 29485; 162 antibodies from 26 providers.
DR DNASU; 14008; -.
DR Ensembl; ENSMUST00000108147; ENSMUSP00000103782; ENSMUSG00000006311.
DR GeneID; 14008; -.
DR KEGG; mmu:14008; -.
DR UCSC; uc009gfm.1; mouse.
DR CTD; 2116; -.
DR MGI; MGI:99253; Etv2.
DR VEuPathDB; HostDB:ENSMUSG00000006311; -.
DR eggNOG; KOG3806; Eukaryota.
DR GeneTree; ENSGT00940000162407; -.
DR HOGENOM; CLU_077571_0_0_1; -.
DR InParanoid; P41163; -.
DR OMA; GLHTDCT; -.
DR PhylomeDB; P41163; -.
DR TreeFam; TF316214; -.
DR BioGRID-ORCS; 14008; 1 hit in 71 CRISPR screens.
DR PRO; PR:P41163; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; P41163; protein.
DR Bgee; ENSMUSG00000006311; Expressed in urethra and 26 other tissues.
DR Genevisible; P41163; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0001824; P:blastocyst development; IMP:MGI.
DR GO; GO:0048514; P:blood vessel morphogenesis; IMP:MGI.
DR GO; GO:0060803; P:BMP signaling pathway involved in mesodermal cell fate specification; IDA:MGI.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0030218; P:erythrocyte differentiation; IMP:MGI.
DR GO; GO:0030097; P:hemopoiesis; IDA:MGI.
DR GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
DR GO; GO:0001707; P:mesoderm formation; IDA:MGI.
DR GO; GO:0007219; P:Notch signaling pathway; IDA:MGI.
DR GO; GO:0001890; P:placenta development; IMP:MGI.
DR GO; GO:0045603; P:positive regulation of endothelial cell differentiation; IDA:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; IDA:MGI.
DR GO; GO:2000382; P:positive regulation of mesoderm development; IDA:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0016055; P:Wnt signaling pathway; IDA:MGI.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; PTHR11849; 1.
DR Pfam; PF00178; Ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..335
FT /note="ETS translocation variant 2"
FT /id="PRO_0000204113"
FT DNA_BIND 234..314
FT /note="ETS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT REGION 94..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 245
FT /note="H -> Q (in Ref. 1; AAA19665)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 335 AA; 37083 MW; BD85BBA5AB636C8D CRC64;
MDLWNWDEAS LQEVPPGDKL TGLGAEFGFY FPEVALQEDT PITPMNVEGC WKGFPELDWN
PALPHEDVPF QAEPVAHPLP WSRDWTDLGC NTSDPWSCAS QTPGPAPPGT SPSPFVGFEG
ATGQNPATSA GGVPSWSHPP AAWSTTSWDC SVGPSGATYW DNGLGGEAHE DYKMSWGGSA
GSDYTTTWNT GLQDCSIPFE GHQSPAFTTP SKSNKQSDRA TLTRYSKTNH RGPIQLWQFL
LELLHDGARS SCIRWTGNSR EFQLCDPKEV ARLWGERKRK PGMNYEKLSR GLRYYYRRDI
VLKSGGRKYT YRFGGRVPVL AYQDDMGHLP GAEGQ
