ID   ETV3L_HUMAN             Reviewed;         361 AA.
AC   Q6ZN32;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=ETS translocation variant 3-like protein;
GN   Name=ETV3L;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Subthalamic nucleus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- FUNCTION: Transcriptional regulator. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q6ZN32; A8MTQ0: NOTO; NbExp=3; IntAct=EBI-17491518, EBI-17490746;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR   EMBL; AK131392; BAD18543.1; -; mRNA.
DR   CCDS; CCDS30893.1; -.
DR   RefSeq; NP_001004341.1; NM_001004341.2.
DR   AlphaFoldDB; Q6ZN32; -.
DR   SMR; Q6ZN32; -.
DR   BioGRID; 136814; 1.
DR   IntAct; Q6ZN32; 1.
DR   STRING; 9606.ENSP00000430271; -.
DR   iPTMnet; Q6ZN32; -.
DR   PhosphoSitePlus; Q6ZN32; -.
DR   BioMuta; ETV3L; -.
DR   DMDM; 74749565; -.
DR   MassIVE; Q6ZN32; -.
DR   PaxDb; Q6ZN32; -.
DR   PeptideAtlas; Q6ZN32; -.
DR   PRIDE; Q6ZN32; -.
DR   ProteomicsDB; 67971; -.
DR   Antibodypedia; 58037; 103 antibodies from 11 providers.
DR   DNASU; 440695; -.
DR   Ensembl; ENST00000454449.3; ENSP00000430271.1; ENSG00000253831.3.
DR   Ensembl; ENST00000671886.1; ENSP00000500322.1; ENSG00000253831.3.
DR   Ensembl; ENST00000671942.1; ENSP00000500028.1; ENSG00000253831.3.
DR   Ensembl; ENST00000672100.1; ENSP00000500154.1; ENSG00000253831.3.
DR   GeneID; 440695; -.
DR   KEGG; hsa:440695; -.
DR   MANE-Select; ENST00000454449.3; ENSP00000430271.1; NM_001004341.2; NP_001004341.1.
DR   UCSC; uc001fqq.3; human.
DR   CTD; 440695; -.
DR   DisGeNET; 440695; -.
DR   GeneCards; ETV3L; -.
DR   HGNC; HGNC:33834; ETV3L.
DR   HPA; ENSG00000253831; Tissue enriched (brain).
DR   neXtProt; NX_Q6ZN32; -.
DR   OpenTargets; ENSG00000253831; -.
DR   PharmGKB; PA162385461; -.
DR   VEuPathDB; HostDB:ENSG00000253831; -.
DR   eggNOG; KOG3806; Eukaryota.
DR   GeneTree; ENSGT00940000162271; -.
DR   HOGENOM; CLU_065588_1_0_1; -.
DR   InParanoid; Q6ZN32; -.
DR   OMA; TPGNWIS; -.
DR   OrthoDB; 677533at2759; -.
DR   PhylomeDB; Q6ZN32; -.
DR   TreeFam; TF351065; -.
DR   PathwayCommons; Q6ZN32; -.
DR   SignaLink; Q6ZN32; -.
DR   BioGRID-ORCS; 440695; 8 hits in 1058 CRISPR screens.
DR   ChiTaRS; ETV3L; human.
DR   GenomeRNAi; 440695; -.
DR   Pharos; Q6ZN32; Tdark.
DR   PRO; PR:Q6ZN32; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q6ZN32; protein.
DR   Bgee; ENSG00000253831; Expressed in nucleus accumbens and 22 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR046328; ETS_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849; PTHR11849; 1.
DR   Pfam; PF00178; Ets; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..361
FT                   /note="ETS translocation variant 3-like protein"
FT                   /id="PRO_0000325822"
FT   DNA_BIND        39..120
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT   REGION          178..201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         19
FT                   /note="S -> A (in dbSNP:rs16838078)"
FT                   /id="VAR_039928"
FT   VARIANT         151
FT                   /note="R -> W (in dbSNP:rs12083811)"
FT                   /id="VAR_048949"
FT   VARIANT         263
FT                   /note="G -> A (in dbSNP:rs12136960)"
FT                   /id="VAR_039929"
FT   VARIANT         318
FT                   /note="M -> V (in dbSNP:rs12126791)"
FT                   /id="VAR_039930"
SQ   SEQUENCE   361 AA;  39948 MW;  5E45866DC31585C9 CRC64;
     MHCSCLAEGI PANPGNWISG LAFPDWAYKA ESSPGSRQIQ LWHFILELLQ KEEFRHVIAW
     QQGEYGEFVI KDPDEVARLW GRRKCKPQMN YDKLSRALRY YYNKRILHKT KGKRFTYKFN
     FSKLIVVNYP LWEVRAPPSP HLLLGAPALC RPALVPVGVQ SELLHSMLFA HQAMVEQLTG
     QQTPRGPPET SGDKKGSSSS VYRLGSAPGP CRLGLCCHLG SVQGELPGVA SFTPPLPPPL
     PSNWTCLSGP FLPPLPSEQQ LPGAFKPDIL LPGPRSLPGA WHFPGLPLLA GLGQGAGERL
     WLLSLRPEGL EVKPAPMMEA KGGLDPREVF CPETRRLKTG EESLTSPNLE NLKAVWPLDP
     P