ETV4_DANRE
ID ETV4_DANRE Reviewed; 494 AA.
AC Q9PUQ1; O57586;
DT 10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=ETS translocation variant 4;
DE AltName: Full=Polyomavirus enhancer activator 3 homolog;
DE Short=Protein PEA3;
GN Name=etv4; Synonyms=pea3;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DNA-BINDING, AND REGULATION
RP OF ACTIVITY.
RC TISSUE=Embryo;
RX PubMed=9671318; DOI=10.1038/sj.onc.1201911;
RA Brown L.A., Amores A., Schilling T.F., Jowett T., Baert J.-L.,
RA de Launoit Y., Sharrocks A.D.;
RT "Molecular characterization of the zebrafish PEA3 ETS-domain transcription
RT factor.";
RL Oncogene 17:93-104(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Embryo;
RX PubMed=10534622; DOI=10.1016/s0925-4773(99)00179-3;
RA Muenchberg S.R., Ober E.A., Steinbeisser H.;
RT "Expression of the Ets transcription factors erm and pea3 in early
RT zebrafish development.";
RL Mech. Dev. 88:233-236(1999).
RN [3]
RP TISSUE SPECIFICITY, AND INDUCTION BY FGF8.
RX PubMed=11413000; DOI=10.1016/s0960-9822(01)00143-9;
RA Roehl H., Nuesslein-Volhard C.;
RT "Zebrafish pea3 and erm are general targets of FGF8 signaling.";
RL Curr. Biol. 11:503-507(2001).
RN [4]
RP TISSUE SPECIFICITY, AND INDUCTION BY FGF3 AND FGF8.
RX PubMed=11520667; DOI=10.1016/s0925-4773(01)00456-7;
RA Raible F., Brand M.;
RT "Tight transcriptional control of the ETS domain factors Erm and Pea3 by
RT Fgf signaling during early zebrafish development.";
RL Mech. Dev. 107:105-117(2001).
CC -!- FUNCTION: Transcriptional activator that binds to the (5'-CCGGA[AT]-3')
CC motif. May control the acquisition of specific cell fates at an early
CC stage during development of the somites and nervous system. May mediate
CC the cellular effects of the fibroblast growth factors on embryogenesis.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
CC -!- TISSUE SPECIFICITY: In the embryo, expressed ubiquitously until the
CC late blastula stage, in the marginal zone of gastrula stages, in the
CC presumptive forebrain and hindbrain and in the trunk region of early
CC somite stages. In later stages, also expressed in Rohon-Beard neurons,
CC epiphysis, lateral line placodes, pectoral fin buds, developing lens
CC and heart. {ECO:0000269|PubMed:10534622, ECO:0000269|PubMed:11413000,
CC ECO:0000269|PubMed:11520667, ECO:0000269|PubMed:9671318}.
CC -!- DEVELOPMENTAL STAGE: First detected in the embryo after 4.3 hours.
CC -!- INDUCTION: By the fibroblast growth factors FGF3 and FGF8.
CC {ECO:0000269|PubMed:11413000, ECO:0000269|PubMed:11520667}.
CC -!- PTM: Phosphorylated. {ECO:0000305}.
CC -!- MISCELLANEOUS: Transcriptional activation activity is enhanced by Raf1,
CC ERK and PKA.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR EMBL; AJ003200; CAA05980.1; -; mRNA.
DR EMBL; AF168008; AAD50434.1; -; mRNA.
DR AlphaFoldDB; Q9PUQ1; -.
DR SMR; Q9PUQ1; -.
DR STRING; 7955.ENSDARP00000016969; -.
DR PaxDb; Q9PUQ1; -.
DR ZFIN; ZDB-GENE-990415-71; etv4.
DR eggNOG; KOG3806; Eukaryota.
DR InParanoid; Q9PUQ1; -.
DR PhylomeDB; Q9PUQ1; -.
DR Reactome; R-DRE-5687128; MAPK6/MAPK4 signaling.
DR PRO; PR:Q9PUQ1; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:ZFIN.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; NAS:UniProtKB.
DR GO; GO:0035108; P:limb morphogenesis; IGI:ZFIN.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0035778; P:pronephric nephron tubule epithelial cell differentiation; IMP:ZFIN.
DR GO; GO:0048793; P:pronephros development; IGI:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:UniProtKB.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR006715; ETS_PEA3_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; PTHR11849; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF04621; ETS_PEA3_N; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..494
FT /note="ETS translocation variant 4"
FT /id="PRO_0000204120"
FT DNA_BIND 350..430
FT /note="ETS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT REGION 82..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 148
FT /note="A -> G (in Ref. 2; AAD50434)"
FT /evidence="ECO:0000305"
FT CONFLICT 177
FT /note="S -> A (in Ref. 2; AAD50434)"
FT /evidence="ECO:0000305"
FT CONFLICT 217..218
FT /note="ID -> MH (in Ref. 2; AAD50434)"
FT /evidence="ECO:0000305"
FT CONFLICT 224..226
FT /note="Missing (in Ref. 2; AAD50434)"
FT /evidence="ECO:0000305"
FT CONFLICT 392..393
FT /note="IE -> MQ (in Ref. 2; AAD50434)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 494 AA; 55621 MW; 81492553EA25C362 CRC64;
MDYKMDGYLD QQVPYTLANR SQGNGPLNRL LMATKRKYMD AELPPQESED LFQDLSQLQE
TWLTEAQVPD SDEQFVPDFH SENSVAFHSP PVKIKKEPQS PGSDPSQSCS HKQSFSYPNG
EQCLYASAYE QKRAAVAGAG GSKSSCPATP MSPMQHYSPK PTVGTRQESG YMNPPSSSQS
HACHSHSYPM NPSSRFPSGS AEMCPPFASQ GQALQRIDPA HASGGGGGGY HRQHSDPCLP
YPPQQTFKQE YMDPLYDRAA HINGPQPQRF PPAHMMVKQE PTDYTYEPDV PGCPSMYHHN
EGYSNPQHNS EGYMFENDSR VVPEKFEGEV KQEGGSVFRE GAPYQRRGSL QLWQFLVALL
DDPSNAHFIA WTGRGMEFKL IEPEEVARLW GIEKNRPAMN YDKLSRSLRY YYEKGIMQKV
AGERYVYKFV CEPEALITLA FPDNQRPSLK AEFERYVNEE DTVPLSHLDE GVSYPPEPAA
TNMGPQPYSK GYMY
