ETV7_HUMAN
ID ETV7_HUMAN Reviewed; 341 AA.
AC Q9Y603; B3KVC2; B4DVB6; B4E1G4; Q5R3L3; Q5R3L4; Q9NZ65; Q9NZ66; Q9NZ68;
AC Q9NZR8; Q9UNJ7; Q9Y5K4; Q9Y604;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 188.
DE RecName: Full=Transcription factor ETV7;
DE AltName: Full=ETS translocation variant 7;
DE AltName: Full=ETS-related protein Tel2;
DE AltName: Full=Tel-related Ets factor;
DE AltName: Full=Transcription factor Tel-2;
GN Name=ETV7; Synonyms=TEL2, TELB, TREF;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), AND CHARACTERIZATION.
RC TISSUE=Hematopoietic;
RX PubMed=10828014;
RA Potter M.D., Buijs A., Kreider B., van Rompaey L., Grosveld G.C.;
RT "Identification and characterization of a new human ETS-family
RT transcription factor, TEL2, that is expressed in hematopoietic tissues and
RT can associate with TEL1/ETV6.";
RL Blood 95:3341-3348(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C; D; E AND F), AND
RP CHARACTERIZATION.
RC TISSUE=Pancreas;
RX PubMed=11108721; DOI=10.1074/jbc.m010070200;
RA Gu X., Shin B.-H., Akbarali Y., Weiss A., Boltax J., Oettgen P.,
RA Libermann T.A.;
RT "Tel-2, a novel transcriptional repressor related to the Ets factor
RT Tel/ETV-6.";
RL J. Biol. Chem. 276:9421-9436(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM G).
RA Smith J.L., Ostrowski M.C.;
RT "TREF-a Tel related Ets factor.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
RX PubMed=11032031; DOI=10.1038/sj.onc.1203830;
RA Poirel H., Lopez R.G., Lacronique V., Della Valle V., Mauchauffe M.,
RA Berger R., Ghysdael J., Bernard O.A.;
RT "Characterization of a novel ETS gene, TELB encoding a protein structurally
RT and functionally related to TEL.";
RL Oncogene 19:4802-4806(2000).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS B; D AND H).
RC TISSUE=Lung, Small intestine, and Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Transcriptional repressor; binds to the DNA sequence 5'-
CC CCGGAAGT-3'. Isoform A does not seem to have a repressor activity.
CC Isoform C does not seem to have a repressor activity.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=8;
CC Name=B;
CC IsoId=Q9Y603-1; Sequence=Displayed;
CC Name=A;
CC IsoId=Q9Y603-2; Sequence=VSP_001473;
CC Name=C;
CC IsoId=Q9Y603-3; Sequence=VSP_001474;
CC Name=D;
CC IsoId=Q9Y603-4; Sequence=VSP_001475;
CC Name=E;
CC IsoId=Q9Y603-5; Sequence=VSP_001477;
CC Name=F;
CC IsoId=Q9Y603-6; Sequence=VSP_001475, VSP_001477;
CC Name=G;
CC IsoId=Q9Y603-7; Sequence=VSP_001476;
CC Name=H;
CC IsoId=Q9Y603-8; Sequence=VSP_044285;
CC -!- TISSUE SPECIFICITY: Expressed in hematopoietic tissues.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR EMBL; AF116508; AAD43250.1; -; mRNA.
DR EMBL; AF116509; AAD43251.1; -; mRNA.
DR EMBL; AF116510; AAD43252.1; -; mRNA.
DR EMBL; AF218235; AAF28350.1; -; mRNA.
DR EMBL; AF218365; AAF44742.1; -; mRNA.
DR EMBL; AF218366; AAF44743.1; -; mRNA.
DR EMBL; AF175387; AAF25007.3; -; mRNA.
DR EMBL; AF147782; AAD33989.1; -; mRNA.
DR EMBL; AJ276205; CAC17012.1; -; mRNA.
DR EMBL; AK122796; BAG53734.1; -; mRNA.
DR EMBL; AK301011; BAG62628.1; -; mRNA.
DR EMBL; AK303829; BAG64776.1; -; mRNA.
DR EMBL; Z84484; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03885.1; -; Genomic_DNA.
DR EMBL; CH471081; EAX03888.1; -; Genomic_DNA.
DR EMBL; CH471081; EAX03890.1; -; Genomic_DNA.
DR EMBL; BC035853; AAH35853.1; -; mRNA.
DR CCDS; CCDS4819.1; -. [Q9Y603-1]
DR CCDS; CCDS56422.1; -. [Q9Y603-8]
DR CCDS; CCDS56423.1; -. [Q9Y603-4]
DR CCDS; CCDS56424.1; -. [Q9Y603-7]
DR CCDS; CCDS56425.1; -. [Q9Y603-5]
DR CCDS; CCDS75440.1; -. [Q9Y603-2]
DR CCDS; CCDS75441.1; -. [Q9Y603-3]
DR CCDS; CCDS78131.1; -. [Q9Y603-6]
DR RefSeq; NP_001193964.1; NM_001207035.1. [Q9Y603-5]
DR RefSeq; NP_001193965.1; NM_001207036.1. [Q9Y603-4]
DR RefSeq; NP_001193966.1; NM_001207037.1. [Q9Y603-2]
DR RefSeq; NP_001193967.1; NM_001207038.1. [Q9Y603-7]
DR RefSeq; NP_001193968.1; NM_001207039.1. [Q9Y603-6]
DR RefSeq; NP_001193969.1; NM_001207040.1. [Q9Y603-3]
DR RefSeq; NP_001193970.1; NM_001207041.1. [Q9Y603-8]
DR RefSeq; NP_057219.1; NM_016135.3. [Q9Y603-1]
DR AlphaFoldDB; Q9Y603; -.
DR SMR; Q9Y603; -.
DR BioGRID; 119581; 33.
DR IntAct; Q9Y603; 27.
DR MINT; Q9Y603; -.
DR STRING; 9606.ENSP00000341843; -.
DR iPTMnet; Q9Y603; -.
DR PhosphoSitePlus; Q9Y603; -.
DR BioMuta; ETV7; -.
DR DMDM; 13124589; -.
DR MassIVE; Q9Y603; -.
DR PaxDb; Q9Y603; -.
DR PeptideAtlas; Q9Y603; -.
DR PRIDE; Q9Y603; -.
DR Antibodypedia; 15369; 303 antibodies from 26 providers.
DR DNASU; 51513; -.
DR Ensembl; ENST00000339796.9; ENSP00000342260.5; ENSG00000010030.14. [Q9Y603-5]
DR Ensembl; ENST00000340181.9; ENSP00000341843.4; ENSG00000010030.14. [Q9Y603-1]
DR Ensembl; ENST00000373737.8; ENSP00000362842.4; ENSG00000010030.14. [Q9Y603-7]
DR Ensembl; ENST00000373738.4; ENSP00000362843.1; ENSG00000010030.14. [Q9Y603-4]
DR Ensembl; ENST00000538992.3; ENSP00000440592.1; ENSG00000010030.14. [Q9Y603-8]
DR Ensembl; ENST00000615781.4; ENSP00000481885.1; ENSG00000010030.14. [Q9Y603-2]
DR Ensembl; ENST00000620358.4; ENSP00000484485.1; ENSG00000010030.14. [Q9Y603-3]
DR Ensembl; ENST00000627426.2; ENSP00000486712.1; ENSG00000010030.14. [Q9Y603-6]
DR GeneID; 51513; -.
DR KEGG; hsa:51513; -.
DR MANE-Select; ENST00000340181.9; ENSP00000341843.4; NM_016135.4; NP_057219.1.
DR UCSC; uc003olz.3; human. [Q9Y603-1]
DR CTD; 51513; -.
DR DisGeNET; 51513; -.
DR GeneCards; ETV7; -.
DR HGNC; HGNC:18160; ETV7.
DR HPA; ENSG00000010030; Tissue enhanced (intestine, skin).
DR MIM; 605255; gene.
DR neXtProt; NX_Q9Y603; -.
DR OpenTargets; ENSG00000010030; -.
DR PharmGKB; PA134980006; -.
DR VEuPathDB; HostDB:ENSG00000010030; -.
DR eggNOG; KOG3804; Eukaryota.
DR GeneTree; ENSGT00940000162211; -.
DR HOGENOM; CLU_037998_0_0_1; -.
DR InParanoid; Q9Y603; -.
DR OMA; SLWLHWA; -.
DR OrthoDB; 827924at2759; -.
DR PhylomeDB; Q9Y603; -.
DR TreeFam; TF318679; -.
DR PathwayCommons; Q9Y603; -.
DR SignaLink; Q9Y603; -.
DR BioGRID-ORCS; 51513; 12 hits in 1097 CRISPR screens.
DR GeneWiki; ETV7; -.
DR GenomeRNAi; 51513; -.
DR Pharos; Q9Y603; Tbio.
DR PRO; PR:Q9Y603; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9Y603; protein.
DR Bgee; ENSG00000010030; Expressed in buccal mucosa cell and 159 other tissues.
DR Genevisible; Q9Y603; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0009887; P:animal organ morphogenesis; TAS:ProtInc.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006366; P:transcription by RNA polymerase II; TAS:ProtInc.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.150.50; -; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; PTHR11849; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF02198; SAM_PNT; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF47769; SSF47769; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR PROSITE; PS51433; PNT; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..341
FT /note="Transcription factor ETV7"
FT /id="PRO_0000204123"
FT DOMAIN 33..117
FT /note="PNT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00762"
FT DNA_BIND 224..305
FT /note="ETS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT REGION 315..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..151
FT /note="Missing (in isoform H)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044285"
FT VAR_SEQ 1..102
FT /note="MQEGELAISPISPVAAMPPLGTHVQARCEAQINLLGEGGICKLPGRLRIQPA
FT LWSREDVLHWLRWAEQEYSLPCTAEHGFEMNGRALCILTKDDFRHRAPSS -> MHRGA
FT RVRDERTRPLHPHQGRLPAPCAQLRSGKRTGFPLSGNP (in isoform A)"
FT /evidence="ECO:0000303|PubMed:11108721"
FT /id="VSP_001473"
FT VAR_SEQ 1..81
FT /note="Missing (in isoform C)"
FT /evidence="ECO:0000303|PubMed:11108721"
FT /id="VSP_001474"
FT VAR_SEQ 49..103
FT /note="Missing (in isoform D and isoform F)"
FT /evidence="ECO:0000303|PubMed:11108721,
FT ECO:0000303|PubMed:14702039"
FT /id="VSP_001475"
FT VAR_SEQ 145..221
FT /note="Missing (in isoform G)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_001476"
FT VAR_SEQ 304..341
FT /note="FLKTPGKMVQDKHSHLEPLESQEQDRIEFKDKRPEISP -> NGLQLIFIFI
FT WSFQ (in isoform E and isoform F)"
FT /evidence="ECO:0000303|PubMed:11108721"
FT /id="VSP_001477"
FT VARIANT 86
FT /note="A -> T (in dbSNP:rs9394345)"
FT /id="VAR_059257"
FT VARIANT 138
FT /note="H -> Y (in dbSNP:rs9470262)"
FT /id="VAR_048952"
FT VARIANT 199
FT /note="G -> S (in dbSNP:rs34306145)"
FT /id="VAR_048953"
FT VARIANT 212
FT /note="P -> L (in dbSNP:rs2234079)"
FT /id="VAR_020314"
FT VARIANT 250
FT /note="A -> V (in dbSNP:rs2234080)"
FT /id="VAR_048954"
FT CONFLICT 27
FT /note="R -> T (in Ref. 1; AAF25007)"
FT /evidence="ECO:0000305"
FT CONFLICT 255
FT /note="V -> G (in Ref. 1; AAF25007)"
FT /evidence="ECO:0000305"
FT CONFLICT 273
FT /note="N -> D (in Ref. 1; AAF25007)"
FT /evidence="ECO:0000305"
FT CONFLICT 311
FT /note="M -> T (in Ref. 1; AAF25007)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 341 AA; 38998 MW; 941983E83E45EBED CRC64;
MQEGELAISP ISPVAAMPPL GTHVQARCEA QINLLGEGGI CKLPGRLRIQ PALWSREDVL
HWLRWAEQEY SLPCTAEHGF EMNGRALCIL TKDDFRHRAP SSGDVLYELL QYIKTQRRAL
VCGPFFGGIF RLKTPTQHSP VPPEEVTGPS QMDTRRGHLL QPPDPGLTSN FGHLDDPGLA
RWTPGKEESL NLCHCAELGC RTQGVCSFPA MPQAPIDGRI ADCRLLWDYV YQLLLDTRYE
PYIKWEDKDA KIFRVVDPNG LARLWGNHKN RVNMTYEKMS RALRHYYKLN IIKKEPGQKL
LFRFLKTPGK MVQDKHSHLE PLESQEQDRI EFKDKRPEIS P
