ID   ETXG_STAAN              Reviewed;         258 AA.
AC   P0A0L7; O85382;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Enterotoxin type G;
DE   AltName: Full=SEG;
DE   Flags: Precursor;
GN   Name=entG; Synonyms=seg; OrderedLocusNames=SA1642;
OS   Staphylococcus aureus (strain N315).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N315;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Staphylococcal enterotoxins cause the intoxication
CC       staphylococcal food poisoning syndrome. The illness is characterized by
CC       high fever, hypotension, diarrhea, shock, and in some cases death.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the staphylococcal/streptococcal toxin family.
CC       {ECO:0000305}.
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DR   EMBL; BA000018; BAB42910.1; -; Genomic_DNA.
DR   PIR; G89968; G89968.
DR   RefSeq; WP_000736712.1; NC_002745.2.
DR   AlphaFoldDB; P0A0L7; -.
DR   SMR; P0A0L7; -.
DR   EnsemblBacteria; BAB42910; BAB42910; BAB42910.
DR   KEGG; sau:SA1642; -.
DR   HOGENOM; CLU_093855_0_1_9; -.
DR   PRO; PR:P0A0L7; -.
DR   Proteomes; UP000000751; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR008992; Enterotoxin.
DR   InterPro; IPR006126; Staph/Strept_toxin_CS.
DR   InterPro; IPR006173; Staph_tox_OB.
DR   InterPro; IPR016091; SuperAg_toxin_C.
DR   InterPro; IPR013307; Superantigen_bac.
DR   InterPro; IPR006123; Toxin_b-grasp_Staph/Strep.
DR   InterPro; IPR006177; Toxin_bac.
DR   Pfam; PF02876; Stap_Strp_tox_C; 1.
DR   Pfam; PF01123; Stap_Strp_toxin; 1.
DR   PRINTS; PR00279; BACTRLTOXIN.
DR   PRINTS; PR01898; SAGSUPRFAMLY.
DR   SUPFAM; SSF50203; SSF50203; 1.
DR   SUPFAM; SSF54334; SSF54334; 1.
DR   PROSITE; PS00278; STAPH_STREP_TOXIN_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Enterotoxin; Secreted; Signal; Superantigen; Toxin;
KW   Virulence.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250"
FT   CHAIN           26..258
FT                   /note="Enterotoxin type G"
FT                   /id="PRO_0000035615"
FT   DISULFID        116..133
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   258 AA;  29940 MW;  E2982101701D012C CRC64;
     MKKLSTVIII LILEIVFHNM NYVNAQPDPK LDELNKVSDY KNNKGTMGNV MNLYTSPPVE
     GRGVINSRQF LSHDLIFPIE YKSYNEVKTE LENTELANNY KDKKVDIFGV PYFYTCIIPK
     SEPDINQNFG GCCMYGGLTF NSSENERDKL ITVQVTIDNR QSLGFTITTN KNMVTIQELD
     YKARHWLTKE KKLYEFDGSA FESGYIKFTE KNNTSFWFDL FPKKELVPFV PYKFLNIYGD
     NKVVDSKSIK MEVFLNTH