ID   EURL_CHICK              Reviewed;         293 AA.
AC   Q9I8W6;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Protein EURL {ECO:0000305};
DE   AltName: Full=Early undifferentiated retina and lens protein {ECO:0000303|PubMed:12815627};
GN   Name=EURL {ECO:0000303|PubMed:12815627};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Lens, and Retina;
RX   PubMed=12815627; DOI=10.1002/dvdy.10310;
RA   Godbout R., Andison R., Katyal S., Bisgrove D.A.;
RT   "Isolation of a novel cDNA enriched in the undifferentiated chick retina
RT   and lens.";
RL   Dev. Dyn. 227:409-415(2003).
CC   -!- FUNCTION: Plays a role in cortical progenitor cell proliferation and
CC       differentiation. May promote dendritic spine development of post-
CC       migratory cortical projection neurons by modulating the beta-catenin
CC       signaling pathway. {ECO:0000250|UniProtKB:Q9D7G4}.
CC   -!- TISSUE SPECIFICITY: Expressed in undifferentiated retina and lens
CC       (PubMed:12815627). {ECO:0000269|PubMed:12815627}.
CC   -!- SIMILARITY: Belongs to the EURL family. {ECO:0000305}.
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DR   EMBL; AF162861; AAF80476.1; -; mRNA.
DR   RefSeq; NP_990068.1; NM_204737.1.
DR   AlphaFoldDB; Q9I8W6; -.
DR   SMR; Q9I8W6; -.
DR   STRING; 9031.ENSGALP00000041567; -.
DR   PaxDb; Q9I8W6; -.
DR   GeneID; 395489; -.
DR   KEGG; gga:395489; -.
DR   CTD; 54149; -.
DR   VEuPathDB; HostDB:geneid_395489; -.
DR   eggNOG; ENOG502QS2B; Eukaryota.
DR   InParanoid; Q9I8W6; -.
DR   OrthoDB; 1172773at2759; -.
DR   PhylomeDB; Q9I8W6; -.
DR   PRO; PR:Q9I8W6; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0021895; P:cerebral cortex neuron differentiation; ISS:UniProtKB.
DR   GO; GO:0060999; P:positive regulation of dendritic spine development; ISS:UniProtKB.
DR   InterPro; IPR009704; EURL_prot.
DR   PANTHER; PTHR15961; PTHR15961; 1.
DR   Pfam; PF06937; EURL; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Differentiation; Neurogenesis; Reference proteome.
FT   CHAIN           1..293
FT                   /note="Protein EURL"
FT                   /id="PRO_0000087076"
FT   COILED          226..260
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   293 AA;  33502 MW;  8D7E8F30829E140A CRC64;
     MNEEQFVNID LDDDNVCSVC KLGTEKETLS FCHICFELNI EGVPKSDLLH TRSLRGHRDC
     FEKFHLIANQ DCPRTKLSRS PYAEVKSILS KKINWIIQYA QNKDIDSDTE SSKTSQHPLF
     NLRHQTDRKL LPQFDSPVPR YSAKWIDGNS GSISNCSQSL LEQSEPTDFR LGMLQETGAT
     FCCSSVLWSN RSQAQKTEKA ESDSLTSPHR RHPHYSREEL NMMTTGELKQ LNEKLLKQIQ
     DVFEELTQQV QEKDSLASEL NVRHIAIEQL LKNCSKLPCL QMGRAGMKSN VPI