ID   EURL_MOUSE              Reviewed;         290 AA.
AC   Q9D7G4;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Protein EURL homolog {ECO:0000305};
GN   Name=Eurl {ECO:0000250|UniProtKB:Q9I8W6};
GN   Synonyms=D16Ertd472e {ECO:0000312|MGI:MGI:1196400};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Tongue;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   FUNCTION, INTERACTION WITH CCDC85B, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RX   PubMed=27404227; DOI=10.1038/srep29514;
RA   Li S.S., Qu Z., Haas M., Ngo L., Heo Y.J., Kang H.J., Britto J.M.,
RA   Cullen H.D., Vanyai H.K., Tan S.S., Chan-Ling T., Gunnersen J.M.,
RA   Heng J.I.;
RT   "The HSA21 gene EURL/C21ORF91 controls neurogenesis within the cerebral
RT   cortex and is implicated in the pathogenesis of Down Syndrome.";
RL   Sci. Rep. 6:29514-29514(2016).
CC   -!- FUNCTION: Plays a role in cortical progenitor cell proliferation and
CC       differentiation (PubMed:27404227). Promotes dendritic spine development
CC       of post-migratory cortical projection neurons by modulating the beta-
CC       catenin signaling pathway (PubMed:27404227).
CC       {ECO:0000269|PubMed:27404227}.
CC   -!- SUBUNIT: Interacts with CCDC85B (PubMed:27404227).
CC       {ECO:0000269|PubMed:27404227}.
CC   -!- TISSUE SPECIFICITY: Expressed in brain (at protein level)
CC       (PubMed:27404227). Expressed in neural progenitor cells and postmitotic
CC       neurons of the embryonic cerebral cortex (PubMed:27404227).
CC       {ECO:0000269|PubMed:27404227}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the embryonic cortex and germinal
CC       ventricular zone (PubMed:27404227). Expressed in cells of the cortical
CC       plate and in retinal pigment epithelium and lens between 12 and 14 dpc
CC       (at protein level) (PubMed:27404227). {ECO:0000269|PubMed:27404227}.
CC   -!- SIMILARITY: Belongs to the EURL family. {ECO:0000305}.
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DR   EMBL; AK009258; BAB26175.1; -; mRNA.
DR   CCDS; CCDS28278.1; -.
DR   RefSeq; NP_001239367.1; NM_001252438.1.
DR   RefSeq; NP_001239368.1; NM_001252439.1.
DR   RefSeq; NP_001239369.1; NM_001252440.1.
DR   RefSeq; NP_080243.3; NM_025967.4.
DR   AlphaFoldDB; Q9D7G4; -.
DR   SMR; Q9D7G4; -.
DR   BioGRID; 211941; 2.
DR   IntAct; Q9D7G4; 2.
DR   STRING; 10090.ENSMUSP00000109858; -.
DR   PhosphoSitePlus; Q9D7G4; -.
DR   EPD; Q9D7G4; -.
DR   MaxQB; Q9D7G4; -.
DR   PaxDb; Q9D7G4; -.
DR   PRIDE; Q9D7G4; -.
DR   ProteomicsDB; 275553; -.
DR   Antibodypedia; 4857; 93 antibodies from 15 providers.
DR   DNASU; 67102; -.
DR   Ensembl; ENSMUST00000114218; ENSMUSP00000109856; ENSMUSG00000022864.
DR   Ensembl; ENSMUST00000114219; ENSMUSP00000109857; ENSMUSG00000022864.
DR   Ensembl; ENSMUST00000114220; ENSMUSP00000109858; ENSMUSG00000022864.
DR   Ensembl; ENSMUST00000231973; ENSMUSP00000156370; ENSMUSG00000022864.
DR   Ensembl; ENSMUST00000232052; ENSMUSP00000156198; ENSMUSG00000022864.
DR   GeneID; 67102; -.
DR   KEGG; mmu:67102; -.
DR   UCSC; uc007zsr.3; mouse.
DR   CTD; 67102; -.
DR   MGI; MGI:1196400; D16Ertd472e.
DR   VEuPathDB; HostDB:ENSMUSG00000022864; -.
DR   eggNOG; ENOG502QS2B; Eukaryota.
DR   GeneTree; ENSGT00390000002429; -.
DR   HOGENOM; CLU_059941_0_0_1; -.
DR   InParanoid; Q9D7G4; -.
DR   OMA; PWLQIGR; -.
DR   OrthoDB; 1172773at2759; -.
DR   PhylomeDB; Q9D7G4; -.
DR   TreeFam; TF331712; -.
DR   BioGRID-ORCS; 67102; 3 hits in 71 CRISPR screens.
DR   ChiTaRS; D16Ertd472e; mouse.
DR   PRO; PR:Q9D7G4; -.
DR   Proteomes; UP000000589; Chromosome 16.
DR   RNAct; Q9D7G4; protein.
DR   Bgee; ENSMUSG00000022864; Expressed in spermatid and 276 other tissues.
DR   ExpressionAtlas; Q9D7G4; baseline and differential.
DR   Genevisible; Q9D7G4; MM.
DR   GO; GO:0021895; P:cerebral cortex neuron differentiation; IMP:UniProtKB.
DR   GO; GO:0060999; P:positive regulation of dendritic spine development; IMP:UniProtKB.
DR   InterPro; IPR009704; EURL_prot.
DR   PANTHER; PTHR15961; PTHR15961; 1.
DR   Pfam; PF06937; EURL; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Differentiation; Neurogenesis; Reference proteome.
FT   CHAIN           1..290
FT                   /note="Protein EURL homolog"
FT                   /id="PRO_0000087078"
FT   REGION          185..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          228..251
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   290 AA;  32883 MW;  44755F1319EC1527 CRC64;
     MNEEEQFVSI DLNDDNICSV CKLGTDKDTL SFCHICFELN LEGVPKSNLL HTKSVRGHKD
     CFEKYHLIAN QDCSRSKLSK STYEGVKTIV SKKINWIVQY AQNKNLDLES ECSKTSQHPL
     LNFRHKPEKK LLPQFDSQVP KYSAKGSAGN AGSISSYAQR ILEHRENTDF RLGLLEDADA
     LWTHSHSQAQ KTEETSSGPE GTIQTQNPHY SREELNSMTL AEVVQLSAKL QQRIQEVFEE
     LTHQVQEKDS LASELHVRHV AIEQLLKNCS KLPCLQVGRT GTRSHLPMNH