EURM3_EURMA
ID EURM3_EURMA Reviewed; 261 AA.
AC O97370;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Mite allergen Eur m 3;
DE EC=3.4.21.-;
DE AltName: Allergen=Eur m 3;
DE Flags: Precursor;
GN Name=EURM3;
OS Euroglyphus maynei (Mayne's house dust mite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Analgoidea;
OC Pyroglyphidae; Pyroglyphinae; Euroglyphus.
OX NCBI_TaxID=6958;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Smith W., Hart B.J., Thomas W.R.;
RL Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALLERGEN: Causes an allergic reaction in human. Common symptoms of mite
CC allergy are bronchial asthma, allergic rhinitis and conjunctivitis.
CC -!- SIMILARITY: Belongs to the peptidase S1 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00274}.
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DR EMBL; AF047615; AAD10712.1; -; mRNA.
DR AlphaFoldDB; O97370; -.
DR SMR; O97370; -.
DR Allergome; 3276; Eur m 3.0101.
DR Allergome; 343; Eur m 3.
DR MEROPS; S01.234; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.40.10.10; -; 1.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF50494; SSF50494; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 1: Evidence at protein level;
KW Allergen; Disulfide bond; Hydrolase; Protease; Secreted; Serine protease;
KW Signal; Zymogen.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT PROPEP 19..29
FT /evidence="ECO:0000250"
FT /id="PRO_0000028149"
FT CHAIN 30..261
FT /note="Mite allergen Eur m 3"
FT /id="PRO_0000028150"
FT DOMAIN 30..260
FT /note="Peptidase S1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT ACT_SITE 69
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 114
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 214
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT SITE 208
FT /note="Required for specificity"
FT DISULFID 54..70
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT DISULFID 181..198
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT DISULFID 210..236
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
SQ SEQUENCE 261 AA; 28038 MW; 6B53BFE63B3850BC CRC64;
MVICNAIIVL LLAFNTLANP ILPSSPNATI VGGQKAKAGE CPYQISLQSS SHFCGGTILD
EYWILTAAHC VNGQTASKLS IRYNSLKHAS GGEKLSVAQI YQHEKYDSWT IDNDIALIKL
QSPMTLDQKN AKSVQLPSQG SDVKVGDKVR VSGWGYLKEG SYSLPSDMYR VDIDIVAREQ
CNKLYEEAGA TITDNMICGG NVADGGVDSC QGDSGGPVVD VASNQIVGIV SWGYGCARKG
YPGVYTRVGS FIDWIDSKRS Q