EUTH_ECOLI
ID EUTH_ECOLI Reviewed; 408 AA.
AC P76552; P76968;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Probable ethanolamine permease EutH {ECO:0000305};
DE AltName: Full=Ethanolamine utilization protein EutH;
GN Name=eutH; Synonyms=yffU; OrderedLocusNames=b2452, JW2436;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K.,
RA Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T., Oyama S.,
RA Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H.,
RA Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.;
RT "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12
RT genome corresponding to 50.0-68.8 min on the linkage map and analysis of
RT its sequence features.";
RL DNA Res. 4:91-113(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP SUBCELLULAR LOCATION.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- FUNCTION: Probably involved in the diffusion of protonated ethanolamine
CC (EA) into the cell at low pH. At low pH most EA is protonated, and this
CC permease becomes necessary. {ECO:0000250|UniProtKB:P41796}.
CC -!- PATHWAY: Amine and polyamine degradation; ethanolamine degradation.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:15919996}.
CC -!- SIMILARITY: Belongs to the EutH family. {ECO:0000305}.
CC -!- CAUTION: In strain MG1655 the eut operon is interrupted by the CPZ-55
CC prophage, encoding 9 genes situated between eutA and eutB, which are
CC translated in the other direction. CPZ-55 may prevent expression of the
CC eut operon in strain MG1655. Strain W3110 does not have this prophage
CC element and should be able to express the operon.
CC {ECO:0000305|PubMed:9278503}.
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DR EMBL; U00096; AAC75505.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA16330.2; -; Genomic_DNA.
DR PIR; C65020; C65020.
DR RefSeq; NP_416947.1; NC_000913.3.
DR RefSeq; WP_000512372.1; NZ_STEB01000039.1.
DR AlphaFoldDB; P76552; -.
DR BioGRID; 4259191; 10.
DR DIP; DIP-9533N; -.
DR IntAct; P76552; 1.
DR STRING; 511145.b2452; -.
DR PaxDb; P76552; -.
DR PRIDE; P76552; -.
DR EnsemblBacteria; AAC75505; AAC75505; b2452.
DR EnsemblBacteria; BAA16330; BAA16330; BAA16330.
DR GeneID; 66673687; -.
DR GeneID; 944979; -.
DR KEGG; ecj:JW2436; -.
DR KEGG; eco:b2452; -.
DR PATRIC; fig|1411691.4.peg.4288; -.
DR EchoBASE; EB3934; -.
DR eggNOG; COG3192; Bacteria.
DR HOGENOM; CLU_061142_0_0_6; -.
DR InParanoid; P76552; -.
DR OMA; FGDHLGF; -.
DR PhylomeDB; P76552; -.
DR BioCyc; EcoCyc:G7282-MON; -.
DR UniPathway; UPA00560; -.
DR PRO; PR:P76552; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0034228; F:ethanolamine transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046336; P:ethanolamine catabolic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR007441; EutH.
DR PANTHER; PTHR40089; PTHR40089; 1.
DR Pfam; PF04346; EutH; 1.
DR PIRSF; PIRSF019466; EutH; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..408
FT /note="Probable ethanolamine permease EutH"
FT /id="PRO_0000087086"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 408 AA; 42807 MW; 6CA68C287E00F612 CRC64;
MGINEIIMYI MMFFMLIAAV DRILSQFGGS ARFLGKFGKS IEGSGGQFEE GFMAMGALGL
AMVGMTALAP VLAHVLGPVI IPVYEMLGAN PSMFAGTLLA CDMGGFFLAK ELAGGDVAAW
LYSGLILGSM MGPTIVFSIP VALGIIEPSD RRYLALGVLA GIVTIPIGCI AGGLVAMYSG
VQINGQPVEF TFALILMNMI PVIIVAILVA LGLKFIPEKM INGFQIFAKF LVALITLGLA
AAVVKFLLGW ELIPGLDPIF MAPGDKPGEV MRAIEVIGSI SCVLLGAYPM VLLLTRWFEK
PLMSVGKVLN MNNIAAAGMV ATLANNIPMF GMMKQMDTRG KVINCAFAVS AAFALGDHLG
FAAANMNAMI FPMIVGKLIG GVTAIGVAMM LVPKEDATAT KTEAEAQS
