ID   EUTP_ECOLI              Reviewed;         159 AA.
AC   P76556; Q2MAI7;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Probable acetate kinase EutP;
DE            EC=2.7.2.1 {ECO:0000250|UniProtKB:P0A208};
DE   AltName: Full=Ethanolamine utilization protein EutP;
GN   Name=eutP; Synonyms=ypfD; OrderedLocusNames=b2461, JW2445;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- FUNCTION: A putative bidirectional acetate kinase that may drive flux
CC       through the ethanolamine degradation pathway under anoxic conditions.
CC       It may generate ATP that can be used by other enzymes (EutA and EutT)
CC       in the eut pathway. {ECO:0000250|UniProtKB:P0A208}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetate + ATP = acetyl phosphate + ADP; Xref=Rhea:RHEA:11352,
CC         ChEBI:CHEBI:22191, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:456216; EC=2.7.2.1;
CC         Evidence={ECO:0000250|UniProtKB:P0A208};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11353;
CC         Evidence={ECO:0000250|UniProtKB:P0A208};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:11354;
CC         Evidence={ECO:0000250|UniProtKB:P0A208};
CC   -!- PATHWAY: Amine and polyamine degradation; ethanolamine degradation.
CC   -!- SUBCELLULAR LOCATION: Bacterial microcompartment
CC       {ECO:0000250|UniProtKB:P0A208}.
CC   -!- SIMILARITY: Belongs to the EutP/PduV family. {ECO:0000305}.
CC   -!- CAUTION: In strain MG1655 the eut operon is interrupted by the CPZ-55
CC       prophage, encoding 9 genes situated between eutA and eutB, which are
CC       translated in the other direction. CPZ-55 may prevent expression of the
CC       eut operon in strain MG1655. Strain W3110 does not have this prophage
CC       element and should be able to express the operon.
CC       {ECO:0000305|PubMed:9278503}.
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DR   EMBL; U00096; AAC75514.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76719.1; -; Genomic_DNA.
DR   PIR; D65021; D65021.
DR   RefSeq; NP_416956.1; NC_000913.3.
DR   RefSeq; WP_000820763.1; NZ_LN832404.1.
DR   AlphaFoldDB; P76556; -.
DR   SMR; P76556; -.
DR   BioGRID; 4260923; 5.
DR   BioGRID; 851272; 1.
DR   IntAct; P76556; 17.
DR   STRING; 511145.b2461; -.
DR   PaxDb; P76556; -.
DR   PRIDE; P76556; -.
DR   EnsemblBacteria; AAC75514; AAC75514; b2461.
DR   EnsemblBacteria; BAE76719; BAE76719; BAE76719.
DR   GeneID; 946933; -.
DR   KEGG; ecj:JW2445; -.
DR   KEGG; eco:b2461; -.
DR   PATRIC; fig|511145.12.peg.2555; -.
DR   EchoBASE; EB3943; -.
DR   eggNOG; COG4917; Bacteria.
DR   HOGENOM; CLU_113298_2_0_6; -.
DR   InParanoid; P76556; -.
DR   OMA; PGEYMEN; -.
DR   PhylomeDB; P76556; -.
DR   BioCyc; EcoCyc:G7291-MON; -.
DR   UniPathway; UPA00560; -.
DR   PRO; PR:P76556; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0031469; C:bacterial microcompartment; IEA:UniProtKB-SubCell.
DR   GO; GO:0008776; F:acetate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046336; P:ethanolamine catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR012381; EutP_PduV.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR40453; PTHR40453; 1.
DR   Pfam; PF10662; PduV-EutP; 1.
DR   PIRSF; PIRSF036409; EutP_PduV; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02528; EutP; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Bacterial microcompartment; Kinase; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..159
FT                   /note="Probable acetate kinase EutP"
FT                   /id="PRO_0000087094"
FT   BINDING         8..15
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   159 AA;  17659 MW;  187F1B6EA23BCEC6 CRC64;
     MKRIAFVGSV GAGKTTLFNA LQGNYTLARK TQAVEFNDKG DIDTPGEYFN HPRWYHALIT
     TLQDVDMLIY VHGANDPESR LPAGLLDIGV SKRQIAVISK TDMPDADVAA TRKLLLETGF
     EEPMFELNSH DPQSVQQLVD YLASLTKQEE AGEKTHHSE