ID   EUTS_ECOL6              Reviewed;         111 AA.
AC   P63747; P76557;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Bacterial microcompartment shell protein EutS;
DE   AltName: Full=Ethanolamine utilization protein EutS;
GN   Name=eutS; OrderedLocusNames=c2987;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: A component of the bacterial microcompartment (BMC) shell
CC       dedicated to ethanolamine degradation. Its unusual hexameric shape may
CC       help form the BMC shell (By similarity). Targets at least 2 proteins
CC       (EutC and EutE) to the interior of the BMC (By similarity). Proteins
CC       such as EutS containing circularly permuted BMC domains may play a key
CC       role in conferring heterogeneity and flexibility in this BMC
CC       (Probable). {ECO:0000250|UniProtKB:P63746,
CC       ECO:0000250|UniProtKB:Q9ZFV7, ECO:0000305}.
CC   -!- PATHWAY: Amine and polyamine degradation; ethanolamine degradation.
CC   -!- SUBUNIT: Homohexamer with a central pore; the hexamer is not symmetric,
CC       it is bent by about 40 degrees; bending depends on Gly-39 (By
CC       similarity). Interacts with the N-terminus of EutC and of EutE,
CC       targeting them to the interior of the BMC (By similarity).
CC       {ECO:0000250|UniProtKB:P63746, ECO:0000250|UniProtKB:Q9ZFV7}.
CC   -!- SUBCELLULAR LOCATION: Bacterial microcompartment
CC       {ECO:0000250|UniProtKB:Q9ZFV7}.
CC   -!- DOMAIN: One side of the hexamer is concave and lined by hydrophobic
CC       residues, the other side has a slightly protruding, 6-stranded beta-
CC       barrel. {ECO:0000250|UniProtKB:P63746}.
CC   -!- SIMILARITY: Belongs to the EutS/PduU family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01279}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN81437.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE014075; AAN81437.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000356956.1; NC_004431.1.
DR   AlphaFoldDB; P63747; -.
DR   SMR; P63747; -.
DR   STRING; 199310.c2987; -.
DR   EnsemblBacteria; AAN81437; AAN81437; c2987.
DR   GeneID; 66673677; -.
DR   KEGG; ecc:c2987; -.
DR   eggNOG; COG4810; Bacteria.
DR   HOGENOM; CLU_143326_0_0_6; -.
DR   OMA; AMIAIND; -.
DR   UniPathway; UPA00560; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0031469; C:bacterial microcompartment; IEA:UniProtKB-SubCell.
DR   GO; GO:0046336; P:ethanolamine catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd07046; BMC_PduU-EutS; 1.
DR   Gene3D; 3.30.70.1710; -; 1.
DR   InterPro; IPR044870; BMC_CP.
DR   InterPro; IPR000249; BMC_dom.
DR   InterPro; IPR037233; CcmK-like_sf.
DR   InterPro; IPR009307; EutS/PduU/CutR.
DR   PANTHER; PTHR40449; PTHR40449; 1.
DR   Pfam; PF00936; BMC; 1.
DR   PIRSF; PIRSF012296; EutS_PduU; 1.
DR   SMART; SM00877; BMC; 1.
DR   SUPFAM; SSF143414; SSF143414; 1.
DR   PROSITE; PS51931; BMC_CP; 1.
PE   3: Inferred from homology;
KW   Bacterial microcompartment.
FT   CHAIN           1..111
FT                   /note="Bacterial microcompartment shell protein EutS"
FT                   /id="PRO_0000201521"
FT   DOMAIN          5..103
FT                   /note="BMC circularly permuted"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01279"
SQ   SEQUENCE   111 AA;  11650 MW;  FBA3F8401EAE26C3 CRC64;
     MDKERIIQEF VPGKQVTLAH LIAHPGEELA KKIGVPDAGA IGIMTLTPGE TAMIAGDLAL
     KAADVHIGFL DRFSGALVIY GSVGAVEEAL SQTVSGLGRL LNYTLCEMTK S