ID   EUTS_SHIFL              Reviewed;         111 AA.
AC   P63748; P76557;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Bacterial microcompartment shell protein EutS;
DE   AltName: Full=Ethanolamine utilization protein EutS;
GN   Name=eutS; OrderedLocusNames=SF2504, S2655;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: A component of the bacterial microcompartment (BMC) shell
CC       dedicated to ethanolamine degradation. Its unusual hexameric shape may
CC       help form the BMC shell (By similarity). Targets at least 2 proteins
CC       (EutC and EutE) to the interior of the BMC (By similarity). Proteins
CC       such as EutS containing circularly permuted BMC domains may play a key
CC       role in conferring heterogeneity and flexibility in this BMC
CC       (Probable). {ECO:0000250|UniProtKB:P63746,
CC       ECO:0000250|UniProtKB:Q9ZFV7, ECO:0000305}.
CC   -!- PATHWAY: Amine and polyamine degradation; ethanolamine degradation.
CC   -!- SUBUNIT: Homohexamer with a central pore; the hexamer is not symmetric,
CC       it is bent by about 40 degrees; bending depends on Gly-39 (By
CC       similarity). Interacts with the N-terminus of EutC and of EutE,
CC       targeting them to the interior of the BMC (By similarity).
CC       {ECO:0000250|UniProtKB:P63746, ECO:0000250|UniProtKB:Q9ZFV7}.
CC   -!- SUBCELLULAR LOCATION: Bacterial microcompartment
CC       {ECO:0000250|UniProtKB:Q9ZFV7}.
CC   -!- DOMAIN: One side of the hexamer is concave and lined by hydrophobic
CC       residues, the other side has a slightly protruding, 6-stranded beta-
CC       barrel. {ECO:0000250|UniProtKB:P63746}.
CC   -!- SIMILARITY: Belongs to the EutS/PduU family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01279}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN44008.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAP17823.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE005674; AAN44008.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE014073; AAP17823.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_708301.1; NC_004337.2.
DR   RefSeq; WP_000356956.1; NZ_WPGW01000011.1.
DR   AlphaFoldDB; P63748; -.
DR   SMR; P63748; -.
DR   STRING; 198214.SF2504; -.
DR   EnsemblBacteria; AAN44008; AAN44008; SF2504.
DR   EnsemblBacteria; AAP17823; AAP17823; S2655.
DR   GeneID; 1025311; -.
DR   GeneID; 66673677; -.
DR   KEGG; sfl:SF2504; -.
DR   KEGG; sfx:S2655; -.
DR   PATRIC; fig|198214.7.peg.2994; -.
DR   HOGENOM; CLU_143326_0_0_6; -.
DR   OrthoDB; 1891661at2; -.
DR   UniPathway; UPA00560; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0031469; C:bacterial microcompartment; IEA:UniProtKB-SubCell.
DR   GO; GO:0046336; P:ethanolamine catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd07046; BMC_PduU-EutS; 1.
DR   Gene3D; 3.30.70.1710; -; 1.
DR   InterPro; IPR044870; BMC_CP.
DR   InterPro; IPR000249; BMC_dom.
DR   InterPro; IPR037233; CcmK-like_sf.
DR   InterPro; IPR009307; EutS/PduU/CutR.
DR   PANTHER; PTHR40449; PTHR40449; 1.
DR   Pfam; PF00936; BMC; 1.
DR   PIRSF; PIRSF012296; EutS_PduU; 1.
DR   SMART; SM00877; BMC; 1.
DR   SUPFAM; SSF143414; SSF143414; 1.
DR   PROSITE; PS51931; BMC_CP; 1.
PE   3: Inferred from homology;
KW   Bacterial microcompartment; Reference proteome.
FT   CHAIN           1..111
FT                   /note="Bacterial microcompartment shell protein EutS"
FT                   /id="PRO_0000201524"
FT   DOMAIN          5..103
FT                   /note="BMC circularly permuted"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01279"
SQ   SEQUENCE   111 AA;  11650 MW;  FBA3F8401EAE26C3 CRC64;
     MDKERIIQEF VPGKQVTLAH LIAHPGEELA KKIGVPDAGA IGIMTLTPGE TAMIAGDLAL
     KAADVHIGFL DRFSGALVIY GSVGAVEEAL SQTVSGLGRL LNYTLCEMTK S