ID   EV45_GAHVM              Reviewed;         211 AA.
AC   P22653; Q77MR7;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   10-FEB-2021, entry version 86.
DE   RecName: Full=Envelope protein UL45 homolog;
GN   Name=UL45H;
OS   Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's
OS   disease herpesvirus type 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Mardivirus.
OX   NCBI_TaxID=10389;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2559540; DOI=10.1007/bf00125125;
RA   Ihara T., Kato A., Ueda S., Ishihama A., Hirai K.;
RT   "Comparison of the sequence of the secretory glycoprotein A (gA) gene in
RT   Md5 and BC-1 strains of Marek's disease virus type 1.";
RL   Virus Genes 3:127-140(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8397281; DOI=10.1099/0022-1317-74-9-1837;
RA   Yanagida N., Yoshida S., Nazerian K., Lee L.F.;
RT   "Nucleotide and predicted amino acid sequences of Marek's disease virus
RT   homologues of herpes simplex virus major tegument proteins.";
RL   J. Gen. Virol. 74:1837-1845(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10933706; DOI=10.1128/jvi.74.17.7980-7988.2000;
RA   Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.;
RT   "The genome of a very virulent Marek's disease virus.";
RL   J. Virol. 74:7980-7988(2000).
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Single-pass type
CC       II membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae HHV-1 UL45 family.
CC       {ECO:0000305}.
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DR   EMBL; D90001; BAA14053.1; -; Genomic_DNA.
DR   EMBL; L10283; AAA03152.1; -; Genomic_DNA.
DR   EMBL; AF243438; AAG14238.1; -; Genomic_DNA.
DR   RefSeq; YP_001033974.1; NC_002229.3.
DR   SMR; P22653; -.
DR   GeneID; 4811519; -.
DR   KEGG; vg:4811519; -.
DR   Proteomes; UP000008072; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR016187; CTDL_fold.
DR   SUPFAM; SSF56436; SSF56436; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW   Transmembrane helix; Viral envelope protein; Virion.
FT   CHAIN           1..211
FT                   /note="Envelope protein UL45 homolog"
FT                   /id="PRO_0000116091"
FT   TOPO_DOM        1..46
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        68..211
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        96
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        133
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   211 AA;  23507 MW;  FFDF3AA525AE38E0 CRC64;
     MMSPTPEDDR DLVVVRGRLR MMDNGAEHDR ERRSYTAWPH LCCGCTIGII LTMFVIATTL
     LLASLFAFSY MSLESGTCPK EWIGLGYSCM RVAGNNATEL EALDMCAQHN SKLVDFTNAK
     TLVEAIVPFG STNASFGNIF RLRDSRSTCI LPTIGGPISV DCPRTCSVVC QRPRPLSTAA
     SIIRDARIYL RLERRDYYEV YSSILSNAIM K