ID   EV45_HHV11              Reviewed;         172 AA.
AC   P10229; Q09I89;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   23-FEB-2022, entry version 79.
DE   RecName: Full=Envelope protein UL45;
DE   AltName: Full=18 kDa protein;
GN   ORFNames=UL45;
OS   Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10299;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2839594; DOI=10.1099/0022-1317-69-7-1531;
RA   McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D.,
RA   Perry L.J., Scott J.E., Taylor P.;
RT   "The complete DNA sequence of the long unique region in the genome of
RT   herpes simplex virus type 1.";
RL   J. Gen. Virol. 69:1531-1574(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nonneuroinvasive mutant HF10;
RX   PubMed=17218138; DOI=10.1016/j.micinf.2006.10.019;
RA   Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.;
RT   "Determination and analysis of the DNA sequence of highly attenuated herpes
RT   simplex virus type 1 mutant HF10, a potential oncolytic virus.";
RL   Microbes Infect. 9:142-149(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17 syn+;
RA   Cunningham C., Davison A.J.;
RT   "Herpes simplex virus type 1 bacterial artificial chromosome.";
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   FUNCTION.
RX   PubMed=8057463; DOI=10.1128/jvi.68.9.5825-5834.1994;
RA   Haanes E.J., Nelson C.M., Soule C.L., Goodman J.L.;
RT   "The UL45 gene product is required for herpes simplex virus type 1
RT   glycoprotein B-induced fusion.";
RL   J. Virol. 68:5825-5834(1994).
RN   [5]
RP   SUBCELLULAR LOCATION.
RC   STRAIN=F;
RX   PubMed=18596102; DOI=10.1128/jvi.00904-08;
RA   Loret S., Guay G., Lippe R.;
RT   "Comprehensive characterization of extracellular herpes simplex virus type
RT   1 virions.";
RL   J. Virol. 82:8605-8618(2008).
CC   -!- FUNCTION: Important virulence factor of HSV neurotropism. Seems to be
CC       required for glycoprotein B-induced fusion. Dispensable for growth in
CC       vitro (By similarity). {ECO:0000250, ECO:0000269|PubMed:8057463}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000269|PubMed:18596102};
CC       Single-pass type II membrane protein {ECO:0000269|PubMed:18596102}.
CC       Note=In transfected cells, it is retained within the ER. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae HHV-1 UL45 family.
CC       {ECO:0000305}.
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DR   EMBL; X14112; CAA32295.1; -; Genomic_DNA.
DR   EMBL; DQ889502; ABI63506.1; -; Genomic_DNA.
DR   EMBL; FJ593289; ACM62268.1; -; Genomic_DNA.
DR   PIR; I30088; WMBEF5.
DR   RefSeq; YP_009137120.1; NC_001806.2.
DR   PRIDE; P10229; -.
DR   GeneID; 24271472; -.
DR   KEGG; vg:24271472; -.
DR   Proteomes; UP000009294; Genome.
DR   Proteomes; UP000180652; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR018002; Herpes_UL45.
DR   PIRSF; PIRSF003509; Herpes_UL45; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW   Transmembrane helix; Viral envelope protein; Virion.
FT   CHAIN           1..172
FT                   /note="Envelope protein UL45"
FT                   /id="PRO_0000116086"
FT   TOPO_DOM        1..27
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..172
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   172 AA;  18180 MW;  EA57EF40D40003D7 CRC64;
     MPLRASEHAY RPLGPGTPPM RARLPAAAWV GVGTIIGGVV IIAALVLVPS RASWALSPCD
     SGWHEFNLGC ISWDPTPMEH EQAVGGCSAP ATLIPRAAAK QLAAVARVQS ARSSGYWWVS
     GDGIRACLRL VDGVGGIDQF CEEPALRICY YPRSPGGFVQ FVTSTRNALG LP