ID   EV45_HHV1K              Reviewed;         172 AA.
AC   P28987;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   23-FEB-2022, entry version 57.
DE   RecName: Full=Envelope protein UL45;
DE   AltName: Full=18 kDa protein;
GN   ORFNames=UL45;
OS   Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10306;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6300426; DOI=10.1128/jvi.45.2.634-647.1983;
RA   Frink R.J., Eisenberg R.J., Cohen G.H., Wagner E.K.;
RT   "Detailed analysis of the portion of the herpes simplex virus type 1 genome
RT   encoding glycoprotein C.";
RL   J. Virol. 45:634-647(1983).
RN   [2]
RP   FUNCTION.
RX   PubMed=11958453; DOI=10.1007/s007050200004;
RA   Visalli R.J., Brandt C.R.;
RT   "Mutation of the herpes simplex virus 1 KOS UL45 gene reveals dose
RT   dependent effects on central nervous system growth.";
RL   Arch. Virol. 147:519-532(2002).
CC   -!- FUNCTION: Important virulence factor of HSV neurotropism. Seems to be
CC       required for glycoprotein B-induced fusion. Dispensable for growth in
CC       vitro (By similarity). {ECO:0000250, ECO:0000269|PubMed:11958453}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Single-pass type
CC       II membrane protein {ECO:0000250}. Note=In transfected cells, it is
CC       retained within the ER. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae HHV-1 UL45 family.
CC       {ECO:0000305}.
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DR   EMBL; J02216; AAA45781.1; -; Genomic_DNA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR018002; Herpes_UL45.
DR   PIRSF; PIRSF003509; Herpes_UL45; 1.
PE   3: Inferred from homology;
KW   Membrane; Signal-anchor; Transmembrane; Transmembrane helix;
KW   Viral envelope protein; Virion.
FT   CHAIN           1..172
FT                   /note="Envelope protein UL45"
FT                   /id="PRO_0000116087"
FT   TOPO_DOM        1..27
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..172
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   172 AA;  18233 MW;  8127EF40D41446C3 CRC64;
     MPLRASEHAY RPLGPGTPPM RARLPAAAWV GVGTIIGGVV IIAALVLVPS RASWALSPCD
     SGWHEFNLGC ISWDPTPMEH EQAVGGCSAP ATLIPRAAAK QLAAVARVQS ARSSGYWWVS
     GDGIRARLRL VDGVGGIDQF CEEPALRICY YPRSPGGFVQ FVTSTRNALG LP