ID   EV45_HHV1M              Reviewed;         172 AA.
AC   P06482;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   23-FEB-2022, entry version 61.
DE   RecName: Full=Envelope protein UL45;
DE   AltName: Full=18 kDa protein;
GN   ORFNames=UL45;
OS   Human herpesvirus 1 (strain MP) (HHV-1) (Human herpes simplex virus 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10307;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6088783; DOI=10.1128/jvi.51.3.578-585.1984;
RA   Draper K.G., Costa R.H., Lee G.T.-Y., Spear P.G., Wagner E.K.;
RT   "Molecular basis of the glycoprotein-C-negative phenotype of herpes simplex
RT   virus type 1 macroplaque strain.";
RL   J. Virol. 51:578-585(1984).
CC   -!- FUNCTION: Important virulence factor of HSV neurotropism. Seems to be
CC       required for glycoprotein B-induced fusion. Dispensable for growth in
CC       vitro (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Single-pass type
CC       II membrane protein {ECO:0000250}. Note=In transfected cells, it is
CC       retained within the ER. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae HHV-1 UL45 family.
CC       {ECO:0000305}.
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DR   EMBL; K03351; AAA45783.1; -; Genomic_DNA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR018002; Herpes_UL45.
DR   PIRSF; PIRSF003509; Herpes_UL45; 1.
PE   3: Inferred from homology;
KW   Membrane; Signal-anchor; Transmembrane; Transmembrane helix;
KW   Viral envelope protein; Virion.
FT   CHAIN           1..172
FT                   /note="Envelope protein UL45"
FT                   /id="PRO_0000116088"
FT   TOPO_DOM        1..27
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..172
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   172 AA;  18201 MW;  6FD20FA17F145C72 CRC64;
     MPLRASEHAY RPLGPGTPPV RARLPAAAWV GVGTIIGGVV IIAALVLVPS RASWALSPCD
     SGWHEFNLGC ISWDPTPMEH EQAVGGCSAP ATLIPRAAAK QLAAVARVQS ARSSGYWWVS
     GDGIRARLRL VDGVGGIDQF CEEPALRICY YPRSPGGFVQ FVTSTRNALG LP