ID   EV45_HHV2H              Reviewed;         172 AA.
AC   P89465;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   02-JUN-2021, entry version 68.
DE   RecName: Full=Envelope protein UL45;
DE   AltName: Full=18 kDa protein;
GN   ORFNames=UL45;
OS   Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10315;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9499055; DOI=10.1128/jvi.72.3.2010-2021.1998;
RA   Dolan A., Jamieson F.E., Cunningham C., Barnett B.C., McGeoch D.J.;
RT   "The genome sequence of herpes simplex virus type 2.";
RL   J. Virol. 72:2010-2021(1998).
CC   -!- FUNCTION: Important virulence factor of HSV neurotropism. Seems to be
CC       required for glycoprotein B-induced fusion (By similarity). Dispensable
CC       for growth in vitro. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Single-pass type
CC       II membrane protein {ECO:0000250}. Note=In transfected cells, it is
CC       retained within the ER. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae HHV-1 UL45 family.
CC       {ECO:0000305}.
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DR   EMBL; Z86099; CAB06731.1; -; Genomic_DNA.
DR   PRIDE; P89465; -.
DR   Proteomes; UP000001874; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR018002; Herpes_UL45.
DR   PIRSF; PIRSF003509; Herpes_UL45; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW   Transmembrane helix; Viral envelope protein; Virion.
FT   CHAIN           1..172
FT                   /note="Envelope protein UL45"
FT                   /id="PRO_0000385469"
FT   TOPO_DOM        1..27
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..172
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   172 AA;  18192 MW;  F9DABA9FE5D6F8C5 CRC64;
     MAFRASGPAY QPLAPAASPA RARVPAVAWI GVGAIVGAFA LVAALVLVPP RSSWGLSPCD
     SGWQEFNAGC VAWDPTPVEH EQAVGGCSAP ATLIPRAAAK HLAALTRVQA ERSSGYWWVN
     GDGIRTCLRL VDSVSGIDEF FEELAIRICY YPRSPGGFVR FVTSIRNALG LP