ID   EV45_PSHV1              Reviewed;         301 AA.
AC   Q6UDL6;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   02-JUN-2021, entry version 49.
DE   RecName: Full=Envelope protein UL45;
GN   Name=UL45;
OS   Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1)
OS   (Pacheco's disease virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Iltovirus.
OX   NCBI_TaxID=670426;
OH   NCBI_TaxID=152276; Amazona oratrix (yellow-headed parrot).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16873243; DOI=10.1128/jvi.00134-06;
RA   Thureen D.R., Keeler C.L. Jr.;
RT   "Psittacid herpesvirus 1 and infectious laryngotracheitis virus:
RT   Comparative genome sequence analysis of two avian alphaherpesviruses.";
RL   J. Virol. 80:7863-7872(2006).
CC   -!- FUNCTION: Seems to be required for glycoprotein B-induced fusion.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane; Single-pass type II membrane
CC       protein. Note=In transfected cells, it is retained within the ER.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae HHV-1 UL45 family.
CC       {ECO:0000305}.
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DR   EMBL; AY372243; AAQ73694.1; -; Genomic_DNA.
DR   RefSeq; NP_944388.1; NC_005264.1.
DR   GeneID; 2656963; -.
DR   KEGG; vg:2656963; -.
DR   Proteomes; UP000006840; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR016187; CTDL_fold.
DR   SUPFAM; SSF56436; SSF56436; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW   Transmembrane helix; Viral envelope protein; Virion.
FT   CHAIN           1..301
FT                   /note="Envelope protein UL45"
FT                   /id="PRO_0000406812"
FT   TOPO_DOM        1..110
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        132..301
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   301 AA;  30945 MW;  F2F119EC6319B1F9 CRC64;
     MRPNGARTQT APPPAAAEGT ADVHGNGEAA TIQLDGQPSA PSPPLTTVFE ATDDYKARRR
     NLESEPPFEV RAILDDELSD YPVAAPLDAV PQKHSCCCGV CLRRCAFVLT GMAVGMLLAA
     ALLATIAAFA VPESVWTGGV CERGWVQHMG VCYKPGRTPP PSSAADGNFS AATFAGANTN
     CAAAGGSIVS SDQALSFLVL LSKTASGPNS APPRGSWWTT HSGSCAIVHY APSSTLEVYG
     NTSSLQSLAL RTRDALDVSI AEDTQCSGSA GVMCAAAPAP PTALKYAQAL RAILTLGVRA
     E