EV983_AMBCJ
ID EV983_AMBCJ Reviewed; 119 AA.
AC A0A023FFB5;
DT 02-DEC-2020, integrated into UniProtKB/Swiss-Prot.
DT 02-DEC-2020, sequence version 2.
DT 25-MAY-2022, entry version 10.
DE RecName: Full=Evasin P983 {ECO:0000303|PubMed:28655871};
DE Flags: Precursor;
OS Amblyomma cajennense (Cayenne tick) (Acarus cajennensis).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Amblyomminae; Amblyomma.
OX NCBI_TaxID=34607;
RN [1] {ECO:0000312|EMBL:JAC19634.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Uberlandia {ECO:0000312|EMBL:JAC19634.1};
RC TISSUE=Salivary gland {ECO:0000312|EMBL:JAC19634.1};
RX PubMed=25201527; DOI=10.1186/1756-3305-7-430;
RA Garcia G.R., Gardinassi L.G., Ribeiro J.M., Anatriello E., Ferreira B.R.,
RA Moreira H.N., Mafra C., Martins M.M., Szabo M.P., de Miranda-Santos I.K.,
RA Maruyama S.R.;
RT "The sialotranscriptome of Amblyomma triste, Amblyomma parvum and Amblyomma
RT cajennense ticks, uncovered by 454-based RNA-seq.";
RL Parasit. Vectors 7:430-430(2014).
RN [2] {ECO:0000305}
RP FUNCTION.
RX PubMed=28655871; DOI=10.1038/s41598-017-04378-1;
RA Singh K., Davies G., Alenazi Y., Eaton J.R.O., Kawamura A.,
RA Bhattacharya S.;
RT "Yeast surface display identifies a family of evasins from ticks with novel
RT polyvalent CC chemokine-binding activities.";
RL Sci. Rep. 7:4267-4267(2017).
CC -!- FUNCTION: Salivary chemokine-binding protein which binds to host
CC chemokines CCL2, CCL3 and CCL8. {ECO:0000269|PubMed:28655871}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=JAC19634.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; GBBK01004848; JAC19634.1; ALT_INIT; mRNA.
DR AlphaFoldDB; A0A023FFB5; -.
DR SMR; A0A023FFB5; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0019957; F:C-C chemokine binding; IDA:UniProtKB.
DR GO; GO:1900137; P:negative regulation of chemokine activity; IEA:InterPro.
DR InterPro; IPR045797; EVA_Class_A.
DR Pfam; PF19429; EVA_Class_A; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Glycoprotein; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..119
FT /note="Evasin P983"
FT /evidence="ECO:0000255"
FT /id="PRO_5001515403"
FT CARBOHYD 48
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 67
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT DISULFID 37..59
FT /evidence="ECO:0000250|UniProtKB:P0C8E7"
FT DISULFID 55..97
FT /evidence="ECO:0000250|UniProtKB:P0C8E7"
FT DISULFID 72..102
FT /evidence="ECO:0000250|UniProtKB:P0C8E7"
FT DISULFID 92..111
FT /evidence="ECO:0000250|UniProtKB:P0C8E7"
SQ SEQUENCE 119 AA; 13124 MW; 9FE5DC65C8F0C43D CRC64;
MKASFCVIAS CLVVFALKGT AEDTGTEDDF DYGNTGCPFP VLGNYKSNMT KPVGCKNKCG
SGYEVLNDTT PCYVIDQKVF NNMVPLRQYS KCPLGFCENG ECKPNDQAED CYKGREEQK