EVA1A_DANRE
ID EVA1A_DANRE Reviewed; 153 AA.
AC Q08CB3;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Protein eva-1 homolog A;
DE AltName: Full=Protein FAM176A;
DE AltName: Full=Transmembrane protein 166;
GN Name=Eva1a; Synonyms=fam176a, tmem166; ORFNames=zgc:153298;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a regulator of programmed cell death, mediating both
CC autophagy and apoptosis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}. Lysosome membrane
CC {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the EVA1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI24309.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; BC124308; AAI24309.1; ALT_INIT; mRNA.
DR RefSeq; NP_001070055.2; NM_001076587.2.
DR RefSeq; XP_017207168.1; XM_017351679.1.
DR AlphaFoldDB; Q08CB3; -.
DR STRING; 7955.ENSDARP00000081999; -.
DR PaxDb; Q08CB3; -.
DR Ensembl; ENSDART00000087565; ENSDARP00000081999; ENSDARG00000061405.
DR GeneID; 767647; -.
DR KEGG; dre:767647; -.
DR CTD; 84141; -.
DR ZFIN; ZDB-GENE-060929-200; eva1a.
DR eggNOG; ENOG502S091; Eukaryota.
DR GeneTree; ENSGT00940000154096; -.
DR HOGENOM; CLU_104871_1_0_1; -.
DR InParanoid; Q08CB3; -.
DR OMA; CHTDCRQ; -.
DR OrthoDB; 1277536at2759; -.
DR PhylomeDB; Q08CB3; -.
DR TreeFam; TF352986; -.
DR Reactome; R-DRE-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
DR Reactome; R-DRE-8957275; Post-translational protein phosphorylation.
DR PRO; PR:Q08CB3; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 17.
DR Bgee; ENSDARG00000061405; Expressed in swim bladder and 9 other tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR InterPro; IPR039500; EVA1_dom.
DR InterPro; IPR039501; EVA1A.
DR PANTHER; PTHR46780:SF14; PTHR46780:SF14; 1.
DR Pfam; PF14851; FAM176; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Autophagy; Endoplasmic reticulum; Lysosome; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..153
FT /note="Protein eva-1 homolog A"
FT /id="PRO_0000278673"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 66..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 153 AA; 17374 MW; 439EF885B82474BB CRC64;
MVTAFLNERQ ATTEEMALVS NALAAYSFIA DQPERAALYF VCGVCLGLVL TLIALVVQIS
CRTDCKTQQA PKKTGKTVEN TSDTSDSDSD WDNTSDLSAR RHRRFERTLG NVFTSAEELE
RAQRLEERER IIREIWMNGQ PDMPGTRSLN RYY
