EVA1B_HUMAN
ID EVA1B_HUMAN Reviewed; 165 AA.
AC Q9NVM1; D3DPS7;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Protein eva-1 homolog B;
DE AltName: Full=Protein FAM176B;
GN Name=EVA1B; Synonyms=C1orf78, FAM176B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Bone, and Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=18318008; DOI=10.1002/pmic.200700884;
RA Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,
RA Zou H., Gu J.;
RT "Large-scale phosphoproteome analysis of human liver tissue by enrichment
RT and fractionation of phosphopeptides with strong anion exchange
RT chromatography.";
RL Proteomics 8:1346-1361(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- INTERACTION:
CC Q9NVM1; P04083: ANXA1; NbExp=3; IntAct=EBI-10314666, EBI-354007;
CC Q9NVM1; P27797: CALR; NbExp=3; IntAct=EBI-10314666, EBI-1049597;
CC Q9NVM1; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-10314666, EBI-3867333;
CC Q9NVM1; P36957: DLST; NbExp=3; IntAct=EBI-10314666, EBI-351007;
CC Q9NVM1; P49639: HOXA1; NbExp=3; IntAct=EBI-10314666, EBI-740785;
CC Q9NVM1; Q8TDX7: NEK7; NbExp=3; IntAct=EBI-10314666, EBI-1055945;
CC Q9NVM1; O43765: SGTA; NbExp=6; IntAct=EBI-10314666, EBI-347996;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the EVA1 family. {ECO:0000305}.
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DR EMBL; AK001509; BAA91729.1; -; mRNA.
DR EMBL; AL591845; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471059; EAX07377.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX07378.1; -; Genomic_DNA.
DR EMBL; BC071697; AAH71697.1; -; mRNA.
DR EMBL; BC006241; AAH06241.1; -; mRNA.
DR CCDS; CCDS406.1; -.
DR RefSeq; NP_001291691.1; NM_001304762.1.
DR RefSeq; NP_060636.1; NM_018166.2.
DR RefSeq; XP_016857116.1; XM_017001627.1.
DR AlphaFoldDB; Q9NVM1; -.
DR BioGRID; 120491; 74.
DR IntAct; Q9NVM1; 10.
DR MINT; Q9NVM1; -.
DR STRING; 9606.ENSP00000270824; -.
DR iPTMnet; Q9NVM1; -.
DR PhosphoSitePlus; Q9NVM1; -.
DR BioMuta; EVA1B; -.
DR DMDM; 74752997; -.
DR EPD; Q9NVM1; -.
DR jPOST; Q9NVM1; -.
DR MassIVE; Q9NVM1; -.
DR MaxQB; Q9NVM1; -.
DR PaxDb; Q9NVM1; -.
DR PeptideAtlas; Q9NVM1; -.
DR PRIDE; Q9NVM1; -.
DR ProteomicsDB; 82825; -.
DR TopDownProteomics; Q9NVM1; -.
DR Antibodypedia; 60829; 19 antibodies from 9 providers.
DR DNASU; 55194; -.
DR Ensembl; ENST00000270824.1; ENSP00000270824.1; ENSG00000142694.7.
DR Ensembl; ENST00000490466.2; ENSP00000507013.1; ENSG00000142694.7.
DR GeneID; 55194; -.
DR KEGG; hsa:55194; -.
DR MANE-Select; ENST00000490466.2; ENSP00000507013.1; NM_001304762.2; NP_001291691.1.
DR UCSC; uc001caj.1; human.
DR CTD; 55194; -.
DR GeneCards; EVA1B; -.
DR HGNC; HGNC:25558; EVA1B.
DR HPA; ENSG00000142694; Low tissue specificity.
DR neXtProt; NX_Q9NVM1; -.
DR OpenTargets; ENSG00000142694; -.
DR PharmGKB; PA162387367; -.
DR VEuPathDB; HostDB:ENSG00000142694; -.
DR eggNOG; ENOG502RYRK; Eukaryota.
DR GeneTree; ENSGT00940000154096; -.
DR HOGENOM; CLU_104871_0_0_1; -.
DR InParanoid; Q9NVM1; -.
DR OMA; GPAPCRD; -.
DR OrthoDB; 1563157at2759; -.
DR PhylomeDB; Q9NVM1; -.
DR TreeFam; TF352986; -.
DR PathwayCommons; Q9NVM1; -.
DR SignaLink; Q9NVM1; -.
DR BioGRID-ORCS; 55194; 8 hits in 1077 CRISPR screens.
DR GenomeRNAi; 55194; -.
DR Pharos; Q9NVM1; Tdark.
DR PRO; PR:Q9NVM1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9NVM1; protein.
DR Bgee; ENSG00000142694; Expressed in descending thoracic aorta and 139 other tissues.
DR Genevisible; Q9NVM1; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR039500; EVA1_dom.
DR InterPro; IPR039502; EVA1B.
DR PANTHER; PTHR46780:SF2; PTHR46780:SF2; 1.
DR Pfam; PF14851; FAM176; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..165
FT /note="Protein eva-1 homolog B"
FT /id="PRO_0000271112"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 57..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 143..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 85
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8K2Y3"
FT MOD_RES 148
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8K2Y3"
FT MOD_RES 158
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8K2Y3"
SQ SEQUENCE 165 AA; 18374 MW; 872485ABDE8B2565 CRC64;
MDAPRRDMEL LSNSLAAYAH IRANPESFGL YFVLGVCFGL LLTLCLLVIS ISWAPRPRPR
GPAQRRDPRS STLEPEDDDE DEEDTVTRLG PDDTLPGPEL SAEPDGPLNV NVFTSAEELE
RAQRLEERER ILREIWRTGQ PDLLGTGTLG PSPTATGTLG RMHYY
