EVA1B_MOUSE
ID EVA1B_MOUSE Reviewed; 164 AA.
AC Q8K2Y3; B1AW02;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Protein eva-1 homolog B;
DE AltName: Full=Protein FAM176B;
GN Name=Eva1b; Synonyms=Fam176b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-86; THR-149 AND THR-157, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the EVA1 family. {ECO:0000305}.
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DR EMBL; AK076006; BAC36114.1; -; mRNA.
DR EMBL; AL731780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466552; EDL30305.1; -; Genomic_DNA.
DR EMBL; CH466552; EDL30306.1; -; Genomic_DNA.
DR EMBL; CH466552; EDL30307.1; -; Genomic_DNA.
DR EMBL; BC029204; AAH29204.1; -; mRNA.
DR CCDS; CCDS18643.1; -.
DR RefSeq; NP_742157.1; NM_172145.3.
DR RefSeq; XP_006503101.1; XM_006503038.3.
DR RefSeq; XP_006503103.1; XM_006503040.3.
DR AlphaFoldDB; Q8K2Y3; -.
DR STRING; 10090.ENSMUSP00000101758; -.
DR iPTMnet; Q8K2Y3; -.
DR PhosphoSitePlus; Q8K2Y3; -.
DR SwissPalm; Q8K2Y3; -.
DR jPOST; Q8K2Y3; -.
DR MaxQB; Q8K2Y3; -.
DR PaxDb; Q8K2Y3; -.
DR PeptideAtlas; Q8K2Y3; -.
DR PRIDE; Q8K2Y3; -.
DR ProteomicsDB; 267666; -.
DR Antibodypedia; 60829; 19 antibodies from 9 providers.
DR Ensembl; ENSMUST00000052876; ENSMUSP00000054141; ENSMUSG00000050212.
DR Ensembl; ENSMUST00000106150; ENSMUSP00000101756; ENSMUSG00000050212.
DR Ensembl; ENSMUST00000106152; ENSMUSP00000101758; ENSMUSG00000050212.
DR GeneID; 230752; -.
DR KEGG; mmu:230752; -.
DR UCSC; uc008usn.1; mouse.
DR CTD; 55194; -.
DR MGI; MGI:1922063; Eva1b.
DR VEuPathDB; HostDB:ENSMUSG00000050212; -.
DR eggNOG; ENOG502RYRK; Eukaryota.
DR GeneTree; ENSGT00940000154096; -.
DR HOGENOM; CLU_104871_0_0_1; -.
DR InParanoid; Q8K2Y3; -.
DR OMA; GPAPCRD; -.
DR OrthoDB; 1565599at2759; -.
DR PhylomeDB; Q8K2Y3; -.
DR TreeFam; TF352986; -.
DR BioGRID-ORCS; 230752; 1 hit in 74 CRISPR screens.
DR PRO; PR:Q8K2Y3; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8K2Y3; protein.
DR Bgee; ENSMUSG00000050212; Expressed in external carotid artery and 195 other tissues.
DR Genevisible; Q8K2Y3; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR039500; EVA1_dom.
DR InterPro; IPR039502; EVA1B.
DR PANTHER; PTHR46780:SF2; PTHR46780:SF2; 1.
DR Pfam; PF14851; FAM176; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..164
FT /note="Protein eva-1 homolog B"
FT /id="PRO_0000271113"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 56..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..88
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 86
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 149
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 157
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 164 AA; 18291 MW; 741FBE87B3C0712F CRC64;
MDAPRRDMEL LSNSLAAYAH IRANPESFGL YFVLGVCFGL LLTLCLLVIS ISCAPRSRPR
TPAPRRDPRS STLEPEDEDD EEDEDTMTRL GPDDTLQGQE LSTEPDGPLS VNVFTSAEEL
ERAQRLEERE RILREIWRTG QPDLLGSGTL GPGATATLGR MHYY
