EVG1_HUMAN
ID EVG1_HUMAN Reviewed; 217 AA.
AC Q9BZE7; Q5JYU9; Q96M68;
DT 16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=UPF0193 protein EVG1;
GN Name=C22orf23;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RX PubMed=11237012; DOI=10.1038/35057141;
RA Shoemaker D.D., Schadt E.E., Armour C.D., He Y.D., Garrett-Engele P.,
RA McDonagh P.D., Loerch P.M., Leonardson A., Lum P.Y., Cavet G., Wu L.F.,
RA Altschuler S.J., Edwards S., King J., Tsang J.S., Schimmack G.,
RA Schelter J.M., Koch J., Ziman M., Marton M.J., Li B., Cundiff P., Ward T.,
RA Castle J., Krolewski M., Meyer M.R., Mao M., Burchard J., Kidd M.J.,
RA Dai H., Phillips J.W., Linsley P.S., Stoughton R., Scherer S.,
RA Boguski M.S.;
RT "Experimental annotation of the human genome using microarray technology.";
RL Nature 409:922-927(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9BZE7; Q96LT6: C1orf74; NbExp=3; IntAct=EBI-10303102, EBI-12049899;
CC Q9BZE7; O95273: CCNDBP1; NbExp=5; IntAct=EBI-10303102, EBI-748961;
CC Q9BZE7; P62508-3: ESRRG; NbExp=3; IntAct=EBI-10303102, EBI-12001340;
CC -!- SIMILARITY: Belongs to the UPF0193 (EVG1) family. {ECO:0000305}.
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DR EMBL; AF324466; AAK07640.1; -; mRNA.
DR EMBL; AK057349; BAB71442.1; -; mRNA.
DR EMBL; CR456440; CAG30326.1; -; mRNA.
DR EMBL; AL031587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471095; EAW60200.1; -; Genomic_DNA.
DR EMBL; BC031998; AAH31998.1; -; mRNA.
DR CCDS; CCDS13962.1; -.
DR RefSeq; NP_001193991.1; NM_001207062.1.
DR RefSeq; NP_115950.3; NM_032561.4.
DR AlphaFoldDB; Q9BZE7; -.
DR SMR; Q9BZE7; -.
DR BioGRID; 124168; 10.
DR IntAct; Q9BZE7; 5.
DR MINT; Q9BZE7; -.
DR STRING; 9606.ENSP00000249079; -.
DR iPTMnet; Q9BZE7; -.
DR PhosphoSitePlus; Q9BZE7; -.
DR BioMuta; C22orf23; -.
DR DMDM; 20177878; -.
DR MassIVE; Q9BZE7; -.
DR PaxDb; Q9BZE7; -.
DR PeptideAtlas; Q9BZE7; -.
DR PRIDE; Q9BZE7; -.
DR Antibodypedia; 258; 55 antibodies from 16 providers.
DR DNASU; 84645; -.
DR Ensembl; ENST00000249079.6; ENSP00000249079.2; ENSG00000128346.11.
DR Ensembl; ENST00000403026.5; ENSP00000384618.1; ENSG00000128346.11.
DR Ensembl; ENST00000403305.6; ENSP00000384667.1; ENSG00000128346.11.
DR GeneID; 84645; -.
DR KEGG; hsa:84645; -.
DR MANE-Select; ENST00000403305.6; ENSP00000384667.1; NM_032561.5; NP_115950.3.
DR UCSC; uc003auj.3; human.
DR CTD; 84645; -.
DR GeneCards; C22orf23; -.
DR HGNC; HGNC:18589; C22orf23.
DR HPA; ENSG00000128346; Tissue enhanced (testis).
DR MIM; 619678; gene.
DR neXtProt; NX_Q9BZE7; -.
DR OpenTargets; ENSG00000128346; -.
DR PharmGKB; PA38355; -.
DR VEuPathDB; HostDB:ENSG00000128346; -.
DR eggNOG; ENOG502RYD0; Eukaryota.
DR GeneTree; ENSGT00390000010231; -.
DR HOGENOM; CLU_081328_0_0_1; -.
DR InParanoid; Q9BZE7; -.
DR OMA; RFNNVQI; -.
DR OrthoDB; 1195866at2759; -.
DR PhylomeDB; Q9BZE7; -.
DR TreeFam; TF323579; -.
DR PathwayCommons; Q9BZE7; -.
DR SignaLink; Q9BZE7; -.
DR BioGRID-ORCS; 84645; 16 hits in 1051 CRISPR screens.
DR ChiTaRS; C22orf23; human.
DR GenomeRNAi; 84645; -.
DR Pharos; Q9BZE7; Tdark.
DR PRO; PR:Q9BZE7; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q9BZE7; protein.
DR Bgee; ENSG00000128346; Expressed in left testis and 103 other tissues.
DR ExpressionAtlas; Q9BZE7; baseline and differential.
DR Genevisible; Q9BZE7; HS.
DR InterPro; IPR007914; UPF0193.
DR PANTHER; PTHR28348; PTHR28348; 1.
DR Pfam; PF05250; UPF0193; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..217
FT /note="UPF0193 protein EVG1"
FT /id="PRO_0000221089"
FT VARIANT 136
FT /note="M -> L (in dbSNP:rs35562630)"
FT /id="VAR_057346"
FT CONFLICT 33
FT /note="L -> F (in Ref. 2; BAB71442)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 217 AA; 24956 MW; 884349333B6E60F0 CRC64;
MASQKQMEVV TKGTGFRRRP KTITYTPGTC ELLRVMMKES KLTNIQQRHI MDIMKRGDAL
PLQCSPTSSQ RVLPSKQIAS PIYLPPILAA RPHLRPANMC QANGAYSREQ FKPQATRDLE
KEKQRLQNIF ATGKDMEERK RKAPPARQKA PAPELDRFEE LVKEIQERKE FLADMEALGQ
GKQYRGIILA EISQKLREME DIDHRRSEEL RKGLATT
