EVI2A_HUMAN
ID EVI2A_HUMAN Reviewed; 236 AA.
AC P22794; B2R5X2; B4DHX8;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 23-MAR-2010, sequence version 2.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Protein EVI2A;
DE AltName: Full=Ecotropic viral integration site 2A protein homolog;
DE Short=EVI-2A;
DE Flags: Precursor;
GN Name=EVI2A; Synonyms=EVDA, EVI2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2117566; DOI=10.1016/0888-7543(90)90199-5;
RA Cawthon R.M., O'Connell P., Buchberg A.M., Viskochil D., Weiss R.B.,
RA Culver M., Stevens J., Jenkins N.A., Copeland N.G., White R.;
RT "Identification and characterization of transcripts from the
RT neurofibromatosis 1 region: the sequence and genomic structure of EVI2 and
RT mapping of other transcripts.";
RL Genomics 7:555-565(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Caudate nucleus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May complex with itself or/and other proteins within the
CC membrane, to function as part of a cell-surface receptor.
CC -!- INTERACTION:
CC P22794; P27449: ATP6V0C; NbExp=3; IntAct=EBI-2870359, EBI-721179;
CC P22794; P21145: MAL; NbExp=3; IntAct=EBI-2870359, EBI-3932027;
CC P22794; Q13021: MALL; NbExp=3; IntAct=EBI-2870359, EBI-750078;
CC P22794; Q04941: PLP2; NbExp=3; IntAct=EBI-2870359, EBI-608347;
CC P22794; Q5VZY2: PLPP4; NbExp=3; IntAct=EBI-2870359, EBI-10485931;
CC P22794; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-2870359, EBI-10244780;
CC P22794; Q9Y5Z9: UBIAD1; NbExp=3; IntAct=EBI-2870359, EBI-2819725;
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P22794-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P22794-2; Sequence=VSP_038859;
CC -!- SIMILARITY: Belongs to the EVI2A family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-5 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA52413.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAG35269.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; M55266; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M55267; AAA52413.1; ALT_INIT; Genomic_DNA.
DR EMBL; AK295311; BAG58290.1; -; mRNA.
DR EMBL; AK312348; BAG35269.1; ALT_INIT; mRNA.
DR EMBL; BC035572; AAH35572.2; -; mRNA.
DR CCDS; CCDS32608.1; -. [P22794-2]
DR CCDS; CCDS42293.1; -. [P22794-1]
DR PIR; A35329; A35329.
DR RefSeq; NP_001003927.1; NM_001003927.2. [P22794-2]
DR RefSeq; NP_055025.2; NM_014210.3. [P22794-1]
DR AlphaFoldDB; P22794; -.
DR SMR; P22794; -.
DR BioGRID; 108424; 20.
DR IntAct; P22794; 15.
DR STRING; 9606.ENSP00000247270; -.
DR GlyGen; P22794; 5 sites.
DR iPTMnet; P22794; -.
DR PhosphoSitePlus; P22794; -.
DR BioMuta; EVI2A; -.
DR DMDM; 292495009; -.
DR MassIVE; P22794; -.
DR PaxDb; P22794; -.
DR PeptideAtlas; P22794; -.
DR PRIDE; P22794; -.
DR ProteomicsDB; 54039; -. [P22794-1]
DR ProteomicsDB; 54040; -. [P22794-2]
DR Antibodypedia; 27020; 83 antibodies from 21 providers.
DR DNASU; 2123; -.
DR Ensembl; ENST00000247270.3; ENSP00000247270.3; ENSG00000126860.12. [P22794-2]
DR Ensembl; ENST00000461237.5; ENSP00000418064.1; ENSG00000126860.12. [P22794-1]
DR Ensembl; ENST00000462804.3; ENSP00000420557.3; ENSG00000126860.12. [P22794-1]
DR GeneID; 2123; -.
DR KEGG; hsa:2123; -.
DR MANE-Select; ENST00000462804.3; ENSP00000420557.3; NM_014210.4; NP_055025.2.
DR UCSC; uc002hgl.4; human. [P22794-1]
DR CTD; 2123; -.
DR DisGeNET; 2123; -.
DR GeneCards; EVI2A; -.
DR HGNC; HGNC:3499; EVI2A.
DR HPA; ENSG00000126860; Tissue enhanced (brain, choroid plexus, lymphoid tissue).
DR MalaCards; EVI2A; -.
DR MIM; 158380; gene.
DR neXtProt; NX_P22794; -.
DR OpenTargets; ENSG00000126860; -.
DR PharmGKB; PA27913; -.
DR VEuPathDB; HostDB:ENSG00000126860; -.
DR eggNOG; ENOG502S3SG; Eukaryota.
DR GeneTree; ENSGT00390000003004; -.
DR HOGENOM; CLU_073339_0_0_1; -.
DR InParanoid; P22794; -.
DR OrthoDB; 1364705at2759; -.
DR PhylomeDB; P22794; -.
DR TreeFam; TF336075; -.
DR PathwayCommons; P22794; -.
DR SignaLink; P22794; -.
DR BioGRID-ORCS; 2123; 13 hits in 1066 CRISPR screens.
DR ChiTaRS; EVI2A; human.
DR GenomeRNAi; 2123; -.
DR Pharos; P22794; Tbio.
DR PRO; PR:P22794; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; P22794; protein.
DR Bgee; ENSG00000126860; Expressed in corpus callosum and 177 other tissues.
DR Genevisible; P22794; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; NAS:UniProtKB.
DR InterPro; IPR008608; Ectropic_vir_integratn_site_2A.
DR PANTHER; PTHR15568; PTHR15568; 1.
DR Pfam; PF05399; EVI2A; 1.
DR PIRSF; PIRSF019625; EVI_S2A; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Phosphoprotein;
KW Proto-oncogene; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..236
FT /note="Protein EVI2A"
FT /id="PRO_0000021211"
FT TOPO_DOM 31..133
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 217..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 211
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P20934"
FT CARBOHYD 31
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 38
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 49
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 73
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 112
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1
FT /note="M -> MLLRSWFGNKDFQALPILARLPSM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_038859"
SQ SEQUENCE 236 AA; 26213 MW; 5C62B05746BD975D CRC64;
MPTDMEHTGH YLHLAFLMTT VFSLSPGTKA NYTRLWANST SSWDSVIQNK TGRNQNENIN
TNPITPEVDY KGNSTNMPET SHIVALTSKS EQELYIPSVV SNSPSTVQSI ENTSKSHGEI
FKKDVCAENN NNMAMLICLI IIAVLFLICT FLFLSTVVLA NKVSSLRRSK QVGKRQPRSN
GDFLASGLWP AESDTWKRTK QLTGPNLVMQ STGVLTATRE RKDEEGTEKL TNKQIG
