EVPLL_HUMAN
ID EVPLL_HUMAN Reviewed; 301 AA.
AC A8MZ36; B4DPD4;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Envoplakin-like protein;
GN Name=EVPLL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-4.
RC TISSUE=Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the plakin or cytolinker family. {ECO:0000305}.
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DR EMBL; AK298286; BAG60546.1; -; mRNA.
DR EMBL; AL353997; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC026998; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC036791; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS45626.1; -.
DR RefSeq; NP_001138599.1; NM_001145127.1.
DR AlphaFoldDB; A8MZ36; -.
DR BioGRID; 570097; 1.
DR STRING; 9606.ENSP00000382086; -.
DR iPTMnet; A8MZ36; -.
DR PhosphoSitePlus; A8MZ36; -.
DR BioMuta; EVPLL; -.
DR jPOST; A8MZ36; -.
DR MassIVE; A8MZ36; -.
DR MaxQB; A8MZ36; -.
DR PaxDb; A8MZ36; -.
DR PeptideAtlas; A8MZ36; -.
DR PRIDE; A8MZ36; -.
DR ProteomicsDB; 2451; -.
DR Antibodypedia; 49961; 88 antibodies from 17 providers.
DR DNASU; 645027; -.
DR Ensembl; ENST00000399134.5; ENSP00000382086.4; ENSG00000214860.5.
DR Ensembl; ENST00000640722.2; ENSP00000492399.1; ENSG00000284166.2.
DR GeneID; 645027; -.
DR KEGG; hsa:645027; -.
DR MANE-Select; ENST00000399134.5; ENSP00000382086.4; NM_001145127.2; NP_001138599.1.
DR UCSC; uc002gte.4; human.
DR CTD; 645027; -.
DR GeneCards; EVPLL; -.
DR HGNC; HGNC:35236; EVPLL.
DR HPA; ENSG00000214860; Group enriched (esophagus, skin, vagina).
DR neXtProt; NX_A8MZ36; -.
DR OpenTargets; ENSG00000214860; -.
DR PharmGKB; PA164719396; -.
DR VEuPathDB; HostDB:ENSG00000214860; -.
DR eggNOG; KOG0516; Eukaryota.
DR GeneTree; ENSGT00940000153578; -.
DR HOGENOM; CLU_924266_0_0_1; -.
DR InParanoid; A8MZ36; -.
DR OMA; CTWQLSA; -.
DR OrthoDB; 1329055at2759; -.
DR PhylomeDB; A8MZ36; -.
DR PathwayCommons; A8MZ36; -.
DR BioGRID-ORCS; 645027; 11 hits in 1058 CRISPR screens.
DR ChiTaRS; EVPLL; human.
DR GenomeRNAi; 645027; -.
DR Pharos; A8MZ36; Tdark.
DR PRO; PR:A8MZ36; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; A8MZ36; protein.
DR Bgee; ENSG00000214860; Expressed in lower esophagus mucosa and 60 other tissues.
DR Genevisible; A8MZ36; HS.
DR GO; GO:0001533; C:cornified envelope; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0019215; F:intermediate filament binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IBA:GO_Central.
DR GO; GO:0008544; P:epidermis development; IEA:InterPro.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0042060; P:wound healing; IBA:GO_Central.
DR InterPro; IPR030460; Envoplakin.
DR InterPro; IPR043197; Plakin.
DR PANTHER; PTHR23169; PTHR23169; 1.
DR PANTHER; PTHR23169:SF7; PTHR23169:SF7; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..301
FT /note="Envoplakin-like protein"
FT /id="PRO_0000395323"
FT REGION 18..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1..88
FT /evidence="ECO:0000255"
FT COMPBIAS 22..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 4
FT /note="S -> N (in dbSNP:rs570145)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_063399"
SQ SEQUENCE 301 AA; 33953 MW; 704AB98521CE2028 CRC64;
MQASADQVER DILETQKRLQ QDRLNSEQSQ ALQHQQETGS SLKEAEVLLK DLFLDVDKAR
RLKHPQAEET EKDIEQLHER VTQECAEYCA LYEKMVLPPR RGIQGRLGTR AGAETEAGLR
RPVWAGHGGA GGTDRGAQHR AEGDQRPRRA AAEPGGAGCR HHPEPIPRPT EGGVVARAEP
GQPVHALQGC TWQLSALAEQ QRRILQQDWS DLMADPAGVR REYEHFKQHE LLSQEQSVNQ
LEEDGKRMVE LRHPAVGPIQ AHQEALKMEW QNFLNLCICQ ETQLQHVEDY SRILCPSSSP
H
