EVX1_MOUSE
ID EVX1_MOUSE Reviewed; 416 AA.
AC P23683;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1991, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Homeobox even-skipped homolog protein 1;
DE AltName: Full=EVX-1;
GN Name=Evx1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Liver;
RX PubMed=1971786; DOI=10.1002/j.1460-2075.1990.tb08309.x;
RA Bastian H., Gruss P.;
RT "A murine even-skipped homologue, Evx 1, is expressed during early
RT embryogenesis and neurogenesis in a biphasic manner.";
RL EMBO J. 9:1839-1852(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RX PubMed=1349539; DOI=10.1016/0012-1606(92)90232-6;
RA Dush M.K., Martin G.R.;
RT "Analysis of mouse Evx genes: Evx-1 displays graded expression in the
RT primitive streak.";
RL Dev. Biol. 151:273-287(1992).
CC -!- FUNCTION: May play a role in the specification of neuronal cell types.
CC May play a role in the dorsoventral specification of mesodermal cell
CC fate.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: Shows a graded distribution in the primitive
CC streak and in cells lateral to it. It is not detected in cells along
CC the A-P axis of the embryo anterior to the primitive streak, except at
CC 7.5 dpc when there is transient expression in the head process. The
CC highest levels of expression are found within the proximal (posterior)
CC portion of the primitive streak and cells near it, with expression
CC levels decreasing more distally (anteriorly).
CC -!- SIMILARITY: Belongs to the even-skipped homeobox family. {ECO:0000305}.
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DR EMBL; X54239; CAA38145.1; -; mRNA.
DR CCDS; CCDS20149.1; -.
DR RefSeq; NP_031992.1; NM_007966.4.
DR AlphaFoldDB; P23683; -.
DR STRING; 10090.ENSMUSP00000031787; -.
DR PaxDb; P23683; -.
DR PRIDE; P23683; -.
DR ProteomicsDB; 267667; -.
DR Antibodypedia; 12413; 174 antibodies from 21 providers.
DR DNASU; 14028; -.
DR Ensembl; ENSMUST00000031787; ENSMUSP00000031787; ENSMUSG00000005503.
DR GeneID; 14028; -.
DR KEGG; mmu:14028; -.
DR UCSC; uc009byv.1; mouse.
DR CTD; 2128; -.
DR MGI; MGI:95461; Evx1.
DR VEuPathDB; HostDB:ENSMUSG00000005503; -.
DR eggNOG; KOG0844; Eukaryota.
DR GeneTree; ENSGT00940000159854; -.
DR HOGENOM; CLU_045075_1_0_1; -.
DR InParanoid; P23683; -.
DR OMA; ERHRIDH; -.
DR OrthoDB; 836887at2759; -.
DR PhylomeDB; P23683; -.
DR TreeFam; TF315938; -.
DR BioGRID-ORCS; 14028; 3 hits in 72 CRISPR screens.
DR PRO; PR:P23683; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P23683; protein.
DR Bgee; ENSMUSG00000005503; Expressed in neural tube marginal layer and 87 other tissues.
DR ExpressionAtlas; P23683; baseline and differential.
DR Genevisible; P23683; MM.
DR GO; GO:0030424; C:axon; IDA:MGI.
DR GO; GO:0043025; C:neuronal cell body; IDA:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:MGI.
DR GO; GO:1904936; P:interneuron migration; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:MGI.
DR GO; GO:0097377; P:spinal cord interneuron axon guidance; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..416
FT /note="Homeobox even-skipped homolog protein 1"
FT /id="PRO_0000048871"
FT DNA_BIND 183..242
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 30..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 416 AA; 43198 MW; 9F0EE4F3677CD3EE CRC64;
MESRKDMVMF LDGGQLGTLV GKRVSNLSEA VSSPLPEPPE KMVPHGCLSP RAGPPTSRER
GGGGQEEEPV DGLAGSAAGL GAEPRSAGAA MLGPGPPVPS ADSLSGQGQP SSSDTESDFY
EEIEVSCTPD CATGNAEYQH SKAPGSDALG SSPTSGSEAP KSNGGSGGSG SQGTLACSAS
DQMRRYRTAF TREQIARLEK EFYRENYVSR PRRCELAAAL NLPETTIKVW FQNRRMKDKR
QRLAMTWPHP ADPAFYTYMM SHAAAAGGLP YPFPSHLPLP YYSPVGLGAA SAASAAASPF
SGPLRPLDTF RVLSQPYPRP ELLCAFRHPP LYPGPAHGLG ASAAAAAAAG PCSCLACHSG
PANGLAPRAA AAAAASDFTC ASTSRSDSFL TFAPSVLSKA SSVAALDQRE EVPLTR
