ID   EVX2_HETFR              Reviewed;         424 AA.
AC   Q9IA18;
DT   11-JUL-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Homeobox even-skipped homolog protein 2;
DE   AltName: Full=EVX-2;
GN   Name=EVX2;
OS   Heterodontus francisci (Horn shark) (Cestracion francisci).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Heterodontoidea; Heterodontiformes;
OC   Heterodontidae; Heterodontus.
OX   NCBI_TaxID=7792;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10677514; DOI=10.1073/pnas.030539697;
RA   Kim C.B., Amemiya C., Bailey W., Kawasaki K., Mezey J., Miller W.,
RA   Minoshima S., Shimizu N., Wagner G., Ruddle F.;
RT   "Hox cluster genomics in the horn shark, Heterodontus francisci.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:1655-1660(2000).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the even-skipped homeobox family. {ECO:0000305}.
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DR   EMBL; AF224263; AAF44638.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9IA18; -.
DR   SMR; Q9IA18; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus.
FT   CHAIN           1..424
FT                   /note="Homeobox even-skipped homolog protein 2"
FT                   /id="PRO_0000048874"
FT   DNA_BIND        179..238
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          18..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          132..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        45..65
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   424 AA;  45629 MW;  DA0DAAF3E35D640E CRC64;
     MERIRKEIIL MERGLHSPAG KKVSNLSDSA GNAVEEALEN SHHSGRLSPR PTSASLHNTV
     GDTPTNGKFE IDNLFHHQHS SDSTSSSEIS SLETRKKFSL YSELACREKE ADMNSDVDVG
     CSTLRSPAGV STTQLKENTN KVYSDNGSST NTSSNGSNIT NLNGNSSSIG NSGSGPDQVR
     RYRTAFTREQ IGRLEKEFYR ENYVSRPRRC ELAAALNLPE TTIKVWFQNR RMKDKRQRLA
     MSWPHPADPS FYTYMMTHAA ATGSLPYPFH SHVPLHYYPH VGVTAAAAAA AATGATPFPT
     SIRPLDTFRA LSHPYSRPEL LCSFRHPGLY QSPHGLNSSA ATAAAAAAAA AAASTPAGTA
     PCSCLSCHSN QSGALGPRSA SSDFTCTATA QRSESSFLPY SAAVLSKSAA VSPPDQREES
     SLTR